4-tert-butyl-2-bromo-1-tert-butyloxy-benzene | 223768-46-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-tert-butyl-2-bromo-1-tert-butyloxy-benzene
• CAS: 223768-46-5
• 化学式: C₁₄H₂₁BrO
• 分子量: 285.224
• InChiKey: HBTPGGXLNWUWQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.92
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  4-tert-butyl-2-bromo-1-tert-butyloxy-benzene 、 L-丙氨酸乙酯盐酸盐 在 碘 、 magnesium 作用下， 生成 (S)-(-)-2-amino-1,1-di-(2'-tert-butyloxy-5'-tert-butyl-phenyl)-1-propanol
  参考文献：
  名称：

  Binuclear versus mononuclear copper complexes as catalysts for asymmetric cyclopropanation of styrene

  摘要：

  A number of (S)-(-)-2-amino-1,1-diaryl-1-propanol compounds have been synthesized. They were used to form the binuclear copper complexes through a spontaneous assembly of the individual components, the beta-aminoalcohol, 2-hydroxy-5-methyl-1,3-benzenedialdehyde, and copper acetate monohydrate, in methanol. These binuclear complexes were examined as asymmetric catalysts for cyclopropanation of styrene by ethyl diazoacetate. Moderate improvement in enantioselectivity has been observed for the binuclear versus mononuclear copper complexes. The e.e. values up to 87% for trans and 93% for cis products and the ratio between trans and cis products up to 9:1 have been obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00009-9
• 作为产物：
  描述：

  1-(tert-butoxy)-4-(tert-butyl)benzene 在 溴 、 potassium carbonate 作用下， 以 四氯化碳 为溶剂， 反应 24.0h， 以88%的产率得到4-tert-butyl-2-bromo-1-tert-butyloxy-benzene
  参考文献：
  名称：

  Binuclear versus mononuclear copper complexes as catalysts for asymmetric cyclopropanation of styrene

  摘要：

  A number of (S)-(-)-2-amino-1,1-diaryl-1-propanol compounds have been synthesized. They were used to form the binuclear copper complexes through a spontaneous assembly of the individual components, the beta-aminoalcohol, 2-hydroxy-5-methyl-1,3-benzenedialdehyde, and copper acetate monohydrate, in methanol. These binuclear complexes were examined as asymmetric catalysts for cyclopropanation of styrene by ethyl diazoacetate. Moderate improvement in enantioselectivity has been observed for the binuclear versus mononuclear copper complexes. The e.e. values up to 87% for trans and 93% for cis products and the ratio between trans and cis products up to 9:1 have been obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00009-9

文献信息

• Binuclear versus mononuclear copper complexes as catalysts for asymmetric cyclopropanation of styrene
  作者：Lisheng Cai、Hussein Mahmoud、Ying Han

  DOI：10.1016/s0957-4166(99)00009-9

  日期：1999.2

  A number of (S)-(-)-2-amino-1,1-diaryl-1-propanol compounds have been synthesized. They were used to form the binuclear copper complexes through a spontaneous assembly of the individual components, the beta-aminoalcohol, 2-hydroxy-5-methyl-1,3-benzenedialdehyde, and copper acetate monohydrate, in methanol. These binuclear complexes were examined as asymmetric catalysts for cyclopropanation of styrene by ethyl diazoacetate. Moderate improvement in enantioselectivity has been observed for the binuclear versus mononuclear copper complexes. The e.e. values up to 87% for trans and 93% for cis products and the ratio between trans and cis products up to 9:1 have been obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.