1-methyl-piperidine-2-carboxylic acid benzylamide | 108239-53-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-methyl-piperidine-2-carboxylic acid benzylamide
• 英文别名: 1-Methyl-piperidin-2-carbonsaeure-benzylamid；N-benzyl-1-methylpiperidine-2-carboxamide
• CAS: 108239-53-8
• 化学式: C₁₄H₂₀N₂O
• 分子量: 232.326
• InChiKey: QSWZXZJOOYHSAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异氰酸苄酯 、 1-甲基哌啶-2-羧酸 生成 1-methyl-piperidine-2-carboxylic acid benzylamide
  参考文献：
  名称：

  af Ekenstam et al., Acta Chemica Scandinavica (1947), 1957, vol. 11, p. 1183,1184

  摘要：

  DOI：

文献信息

• COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE
  申请人：Yale University

  公开号：EP3608317A1

  公开（公告）日：2020-02-12

  The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

  本发明涉及双功能化合物，它们可作为靶向泛素化的调节剂，特别是可被根据本发明的双功能化合物降解和/或以其他方式抑制的各种多肽和其他蛋白质。特别是，本发明涉及的化合物一端含有与泛素连接酶结合的 VHL 配体，另一端含有与靶蛋白结合的分子，从而使靶蛋白靠近泛素连接酶，以实现对该蛋白的降解（和抑制）。本发明显示了与根据本发明的化合物相关的广泛的药理活性，与降解/抑制靶向多肽一致。
• af Ekenstam et al., Acta Chemica Scandinavica (1947), 1957, vol. 11, p. 1183,1184
  作者：af Ekenstam et al.

  DOI：——

  日期：——