4-(3-bromo-4-fluorophenyl)-1-methyl-4,9-dihydro-1H-isoxazolo[3,4-b]pyrano[4,3-e]pyridine-3,5(6H,8H)-dione | 359867-22-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 4-(3-bromo-4-fluorophenyl)-1-methyl-4,9-dihydro-1H-isoxazolo[3,4-b]pyrano[4,3-e]pyridine-3,5(6H,8H)-dione
• 英文别名: 4-(3-bromo-4-fluorophenyl)-1-methyl-4,9-dihydro-1 H-isoxazolo[3,4-b]pyrano[4,3-e]pyridine-3,5(6H,8H)-dione；8-(3-bromo-4-fluorophenyl)-4-methyl-5,12-dioxa-2,4-diazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10-dione
• CAS: 359867-22-4
• 化学式: C₁₆H₁₂BrFN₂O₄
• 分子量: 395.185
• InChiKey: JVQGBUBSSQNHBI-UHFFFAOYSA-N

物化性质

• 沸点：
  529.1±60.0 °C(predicted)
• 密度：
  1.77±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-(3-bromo-4-fluorophenyl)-1-methyl-4,9-dihydro-1H-isoxazolo[3,4-b]pyrano[4,3-e]pyridine-3,5(6H,8H)-dione 在 Chiracel AS 作用下， 以 乙醇 、 正己烷 为溶剂， 以0.07 g的产率得到(-)-(S)-4-(3-bromo-4-fluorophenyl)-1-methyl-4,9-dihydro-1H-isoxazolo[3,4-b]pyrano[4,3-e]pyridine-3,5(6H,8H)-dione
  参考文献：
  名称：

  Structure–activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as KATP channel openers

  摘要：

  In search of a novel chemotype of KATP channel openers a series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones was synthesized. It was found that cyclopentanone in the left hand portion of the molecule was 4-fold more potent than cyclohexanone. Introduction of gem-dimethyl groups as well as incorporation of oxygen in the cyclohexanone ring in the left hand portion of the molecule increased the potency 10-fold. In the right hand portion of the molecule, the NH-group of the pyrazolone can be effectively substituted by oxygen increasing the activity 5-fold. Incorporation of a methyl group adjacent to the dihydropyridine (DHP) nitrogen not only significantly boosted activity, but also provided an additional benefit of increased metabolic stability. In vitro tests on the tissue from pig bladder strips provided further confirmation of K-ATP activity of these compounds. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.01.038
• 作为产物：
  描述：

  2H-吡喃-3,5(4H,6H)-二酮 、 3-溴-4-氟苯甲醛 、 3-氨基-2-甲基-1,2-恶唑-5-酮 在 dichloromethane ethanol 作用下， 以 乙醇 为溶剂， 反应 48.0h， 以to provide the title compound as a white solid (0.09 g)的产率得到4-(3-bromo-4-fluorophenyl)-1-methyl-4,9-dihydro-1H-isoxazolo[3,4-b]pyrano[4,3-e]pyridine-3,5(6H,8H)-dione
  参考文献：
  名称：

  Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers

  摘要：

  公式I的化合物在治疗由钾通道开放剂预防或缓解的疾病方面非常有用。还揭示了开放钾通道的组合物和在哺乳动物中开放钾通道的方法。

  公开号：

  US06780872B2

文献信息

• TRICYCLIC DIHYDROPYRAZOLONE AND TRICYCLIC DIHYDROISOXAZOLONE POTASSIUM CHANNEL OPENERS
  申请人：ABBOTT LABORATORIES

  公开号：EP1259510A2

  公开（公告）日：2002-11-27
• Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels
  申请人：Herlands Louis

  公开号：US20070026079A1

  公开（公告）日：2007-02-01

  Provided are methods of increasing K ATP channel activity in the hypothalamus of a mammal, methods of reducing glucose production in a mammal, methods of reducing peripheral glucose levels in a mammal, methods of reducing triglyceride levels in a mammal, methods of reducing very low density lipoprotein (VLDL) levels in a mammal, methods of methods of reducing gluconeogenesis in the liver of a mammal, methods of treating metabolic disorders such as diabetes, hyperglycemia, insulin resistance, glucose intolerance, metabolic syndrome and/or obesity, and methods of increasing glucose production and peripheral glucose levels in a mammal. Also provided are methods of treating heart failure, ischemia, coronary heart disease, familial lipoprotein lipase deficiency, hypopituitarism, hyperlipidemia, hypertriglyceridemia, hyperVLDLemia, atherosclerosis, hypercholesterolemia, hypertension, polycystic ovary syndrome, gonadotropin deficiency and/or amenorrhea.
• Modulation of Hypothalamic Atp-Sensitive Potassium Channels
  申请人：Rossetti Luciano

  公开号：US20090012067A1

  公开（公告）日：2009-01-08

  Provided are methods of increasing K ATP activity in the hypothalamus of a mammal, methods of reducing glucose production and peripheral blood glucose levels in a mammal, methods of inhibiting gluconeogenesis in the liver of a mammal, and methods of increasing glucose production and peripheral blood glucose levels in a mammal.
• US6538004B2
  申请人：——

  公开号：US6538004B2

  公开（公告）日：2003-03-25
• US6780872B2
  申请人：——

  公开号：US6780872B2

  公开（公告）日：2004-08-24