2-amino-4-cyano-1-methoxymethoxybenzene | 402473-90-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-amino-4-cyano-1-methoxymethoxybenzene
• 英文别名: 3-Amino-4-(methoxymethoxy)benzonitrile
• CAS: 402473-90-9
• 化学式: C₉H₁₀N₂O₂
• 分子量: 178.191
• InChiKey: CAOKBGXSGAKAGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  68.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-methyl-2-(1-naphthyl)pentanoyl chloride 、 草酰氯 、 2-amino-4-cyano-1-methoxymethoxybenzene 在 盐酸 、 sodium chloride 作用下， 以 N-甲基乙酰胺 、 二氯甲烷 、 甲苯 为溶剂， 生成 N-(5-cyano-2-methoxymethoxyphenyl)-4methyl-2-(1-naphthyl)pentanamide
  参考文献：
  名称：

  Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient

  摘要：

  化学式（1）1的羧酸衍生物，其中R1是COOH，COOR6等；A是烷基等；R2是烷基，烯基，炔基等；B是碳环或杂环；R4是烷基，环烷基等；R6是碳环或杂环；或其无毒盐，以其为活性成分的制备方法和含有其的药物制剂。化合物的化学式（I）可以结合到前列腺素E2受体，特别是EP3受体和/或EP4受体，并显示拮抗活性，对于预防和/或治疗疾病，例如疼痛，过敏，阿尔茨海默病，癌症等非常有用。

  公开号：

  US20030216381A1

文献信息

• Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical agents comprising the same as active ingredient
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US20040235825A1

  公开（公告）日：2004-11-25

  A carboxylic acid derivative of formula (I) 1 wherein R 1 , COOH, COOR 6 etc.; A is alkylene etc.; R 2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R 4 is alkyl, cycloalkyl etc.; R 5 is carbocyclic ring or heterocyclic ring; or non-toxic salts thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same as active ingredient. The compound of the formula (I) can bind to Prostaglandin E 2 receptors, especially, EP 3 receptor and/or EP 4 receptor and show the antagonizing activity, and useful for the prevention and/or treatment of disease, for example, pain, allergy, Alzheimer's disease, cancer.

  化合物的式(I)1为羧酸衍生物，其中R1，COOH，COOR6等; A为亚烷基等; R2为烷基，烯基，炔基等; B为碳环或杂环; R4为烷基，环烷基等; R5为碳环或杂环;或其无毒盐，其制备方法以及包含其作为活性成分的药物制剂。公式(I)的化合物可以结合到前列腺素E2受体，特别是EP3受体和/或EP4受体，并表现出拮抗活性，可用于预防和/或治疗疾病，例如疼痛，过敏，阿尔茨海默病，癌症。
• Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical aggents comprising the same as active ingredient
  申请人：Tani Kousuke

  公开号：US20050026908A1

  公开（公告）日：2005-02-03

  A carboxylic acid derivative of formula (I) wherein R 1 is COOH, COOR 6 etc.; A is alkylene etc.; R 2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R 4 is alkyl, cycloalkyl etc.; R 6 is carbocyclic ring or heterocyclic ring; or non-toxic salts thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same as active ingredient. The compound of the formula (I) can bind to Prostaglandin E 2 receptors, especially, EP 3 receptor and/or EP 4 receptor and show the antagonizing activity, and useful for the prevention and/or treatment of disease, for example, pain, allergy, Alzheimer's disease, cancer.

  化合物公式（I）的羧酸衍生物，其中R1为COOH，COOR6等; A为烷基等; R2为烷基，烯基，炔基等; B为碳环或杂环; R4为烷基，环烷基等; R6为碳环或杂环; 或其非毒性盐，其制备方法以及包含其作为活性成分的制药剂。公式（I）的化合物可以结合到前列腺素E2受体，特别是EP3受体和/或EP4受体，并显示拮抗活性，有助于预防和/或治疗疾病，例如疼痛，过敏，阿尔茨海默病，癌症。
• CARBOXYLIC ACID DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1312601A1

  公开（公告）日：2003-05-21

  A carboxylic acid derivative of formula (I) wherein R1 is COOH, COOR6 etc.; A is alkylene etc.; R2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R4 is alkyl, cycloalkyl etc.; R5 is carbocyclic ring or heterocyclic ring; or non-toxic salts thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same as active ingredient. The compound of the formula (I) can bind to Prostaglandin E2 receptors, especially, EP3 receptor and/or EP4 receptor and show the antagonizing activity, and useful for the prevention and/or treatment of disease, for example, pain, allergy, Alzheimer' s disease, cancer.

  式（I）的羧酸衍生物 其中 R1 是 COOH、COOR6 等；A 是亚烷基等；R2 是烷基、烯基、炔基等；B 是碳环或杂环；R4 是烷基、环烷基等；R5 是碳环或杂环； 或其无毒盐、其制备方法以及以其为活性成分的药物制剂。 式（I）化合物可与前列腺素 E2 受体，特别是 EP3 受体和/或 EP4 受体结合并显示出拮抗活性，可用于预防和/或治疗疾病，例如疼痛、过敏、老年痴呆症、癌症。
• US6835752B2
  申请人：——

  公开号：US6835752B2

  公开（公告）日：2004-12-28
• Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient
  申请人：——

  公开号：US20030216381A1

  公开（公告）日：2003-11-20

  A carboxylic acid derivative of formula (1) 1 wherein R 1 is COOH, COOR 6 etc.; A is alkylene etc.; R 2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R 4 is alkyl, cycloalkyl etc.; R 6 is carbocyclic ring or heterocyclic ring; or non-toxic salts thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same as active ingredient. The compound of the formula (I) can bind to Prostaglandin E 2 receptors, especially, EP 3 receptor and/or EP 4 receptor and show the antagonizing activity, and useful for the prevention and/or treatment of disease, for example, pain, allergy, Alzheimer's disease, cancer.

  化学式（1）1的羧酸衍生物，其中R1是COOH，COOR6等；A是烷基等；R2是烷基，烯基，炔基等；B是碳环或杂环；R4是烷基，环烷基等；R6是碳环或杂环；或其无毒盐，以其为活性成分的制备方法和含有其的药物制剂。化合物的化学式（I）可以结合到前列腺素E2受体，特别是EP3受体和/或EP4受体，并显示拮抗活性，对于预防和/或治疗疾病，例如疼痛，过敏，阿尔茨海默病，癌症等非常有用。