rac N-Desmethyl Tramadol | 75377-45-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: rac N-Desmethyl Tramadol
• 英文别名: (1R,2R)-1-(3-methoxyphenyl)-2-(methylaminomethyl)cyclohexan-1-ol
• CAS: 75377-45-6
• 化学式: C₁₅H₂₃NO₂
• 分子量: 249.35
• InChiKey: VUMQHLSPUAFKKK-HIFRSBDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Opioid Detection
  申请人：Randox Laboratories Limited

  公开号：US20170176476A1

  公开（公告）日：2017-06-22

  An immunoassay method is described which detects O-desmethyltramadol only. This enables an assay of high sensitivity and specificity avoiding false positive results. The unique antibodies incorporated in the immunoassay method can be combined with antibodies which detect mitragynine to provide an assay which increases the possibility of detecting the commonly found drug combination of O-desmethyltramadol and mitragynine.

  描述了一种免疫分析方法，仅检测O-去甲基曲马多。这使得检测具有高灵敏度和特异性的方法成为可能，避免了假阳性结果。免疫分析方法中所包含的独特抗体可以与检测米特拉吉宁的抗体结合，从而提供一种增加检测常见药物组合O-去甲基曲马多和米特拉吉宁可能性的检测方法。
• Immunoassay for tramadol and its major metabolites
  申请人：Randox Laboratories Ltd.

  公开号：EP1988398A1

  公开（公告）日：2008-11-05

  The invention provides a method and kit for detecting and determining tramadol and its major metabolites N-demethyltramadol and O-demethyltramadol using novel conjugates, immunogens and antibodies derived from N-derivatised and O-derivatised tramadol.

  本发明提供了一种检测和确定曲马多及其主要代谢物 N-去甲基曲马多和 O-去甲基曲马多的方法和试剂盒，该方法和试剂盒使用新型共轭物、免疫原和抗体，这些免疫原和抗体来自 N-衍生化曲马多和 O-衍生化曲马多。
• Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
  申请人：Sepracor Inc.

  公开号：EP2617704A1

  公开（公告）日：2013-07-24

  Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g. from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

  本文公开了苯基取代的环己胺衍生物及其合成和表征方法。本文阐述了这些化合物在治疗/预防神经系统疾病方面的用途及其合成方法。本发明的示例化合物可抑制多巴胺、5-羟色胺和去甲肾上腺素等内源性单胺的再摄取（例如从突触间隙），并调节一种或多种单胺转运体。还提供了含有本发明化合物的药物制剂。
• PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS
  申请人：Sunovion Pharmaceuticals Inc.

  公开号：EP3296289A2

  公开（公告）日：2018-03-21

  Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g. from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

  本文公开了苯基取代的环己胺衍生物及其合成和表征方法。本文阐述了这些化合物在治疗/预防神经系统疾病方面的用途及其合成方法。本发明的示例化合物可抑制多巴胺、5-羟色胺和去甲肾上腺素等内源性单胺的再摄取（例如从突触间隙），并调节一种或多种单胺转运体。还提供了含有本发明化合物的药物制剂。
• Opioid detection
  申请人：Randox Laboratories Limited

  公开号：US10416175B2

  公开（公告）日：2019-09-17

  An immunoassay method is described which detects O-desmethyltramadol only. This enables an assay of high sensitivity and specificity avoiding false positive results. The unique antibodies incorporated in the immunoassay method can be combined with antibodies which detect mitragynine to provide an assay which increases the possibility of detecting the commonly found drug combination of O-desmethyltramadol and mitragynine.

  介绍了一种仅检测 O-去甲基曲马多的免疫测定方法。这种检测方法灵敏度高、特异性强，可避免出现假阳性结果。免疫测定方法中的独特抗体可与检测米屈肼的抗体结合使用，从而提供一种更有可能检测出 O-去甲曲马多和米屈肼这两种常见药物组合的检测方法。