N-acetyl dehydrophenylalanylglycine | 24719-37-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl dehydrophenylalanylglycine
• 英文别名: Ac-ΔPhe-Gly-OH；N-(α-acetylamino-cinnamoyl)-glycine；N-(α-Acetylamino-cinnamoyl)-glycin；N-(α-Acetamino-cinnamoyl)-glycin；N-(α-Acetimino-β-phenyl-propionyl)-glycin；2-Acetylamino-3-phenyl-acrylsaeure-(carboxymethylamid)；2-[(2-Acetamido-3-phenylprop-2-enoyl)amino]acetic acid
• CAS: 24719-37-7
• 化学式: C₁₃H₁₄N₂O₄
• 分子量: 262.265
• InChiKey: KHFHYZUGAWUIKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-acetyl dehydrophenylalanylglycine 在 甲醇 、 钯 、 溶剂黄146 作用下， 生成 N-乙酰基-1-苯基丙氨酰甘氨酸
  参考文献：
  名称：

  Bergmann; Behrens, Journal of Biological Chemistry, 1938, vol. 124, p. 7,9

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(α-acetylamino-cinnamoyl)-glycine ethyl ester 在 sodium hydroxide 作用下， 生成 N-acetyl dehydrophenylalanylglycine
  参考文献：
  名称：

  Graenacher; Mahler, Helvetica Chimica Acta, 1927, vol. 10, p. 256

  摘要：

  DOI：

文献信息

• Asymmetric Hydrogenation with Rhodium(I)–Chiral Diphosphinites. The Effect of the Dimethylamino Group of the Ligand on the Asymmetric Induction
  作者：Masanobu Yatagai、Masanobu Zama、Takamichi Yamagishi、Mitsuhiko Hida

  DOI：10.1246/bcsj.57.739

  日期：1984.3

  New chiral diphosphinites were prepared starting from (+)-diethyl tartrate. The asymmetric hydrogenation of dehydroamino acids, itaconic acid and dehydrodipeptides was studied using Rh(I)-diphosphinite catalysts. In the hydrogenation of dehydroamino acid derivatives, an introducion of ω-(dimethylamino)alkyl group in the ligands did not raise the optical yield. By the use of Rh(I)-diphosphinite having

  以(+)-酒石酸二乙酯为原料制备了新的手性二亚膦酸酯。使用 Rh(I)-二亚膦酸盐催化剂研究了脱氢氨基酸、衣康酸和脱氢二肽的不对称氢化。在脱氢氨基酸衍生物的氢化中，配体中ω-(二甲氨基)烷基的引入不会提高光学产率。通过使用具有3-(二甲氨基)丙基的Rh(I)-二亚膦酸酯，观察到优选产物的转化。通过使用具有2-(二甲氨基)乙基的二亚膦酸酯，衣康酸可以以良好的光学产率(76%ee)氢化。在具有手性中心的脱氢二肽的情况下，具有ω-二甲氨基的二亚膦酸酯具有高光学产率。特别是在 Ac–ΔPhe–(S)-Phe– 的情况下，由二亚膦酸酯与配体苯环上的 4-甲基或 4-甲氧基基团配位的 Rh(I)-催化剂具有优异的立体选择性（超过 98% de）哦。这些新的手性二亚膦酸盐对作为...
• Doherty; Tietzman; Bergmann, Journal of Biological Chemistry, 1943, vol. 147, p. 617,631
  作者：Doherty、Tietzman、Bergmann

  DOI：——

  日期：——
• Tietzman et al., Journal of Biological Chemistry, 1943, vol. 151, p. 387,389
  作者：Tietzman et al.

  DOI：——

  日期：——
• Relation between type a behavior pattern and the extent of coronary atherosclerosis in Japanese women
  作者：Kouichi Yoshimasu、Masakazu Washio、Shoji Tokunaga、Keitaro Tanaka、Ying Liu、Hiroko Kodama、Hidekazu Arai、Samon Koyanagi、Koji Hiyamuta、Yoshitaka Doi、Tomoki Kawano、Osamu Nakagaki、Kazuyuki Takada、Shizuka Sasazuki、Takanobu Nii、Kazuyuki Shirai、Munehito Ideishi、Kikuo Arakawa、Masahiro Mohri、Akira Takeshita

  DOI：10.1207/s15327558ijbm0902_01

  日期：2002.6

  This study examined the relation of Type A behavior pattern and its components to angiographically documented coronary atherosclerosis in 198 Japanese women. A questionnaire-based interview elicited psychosocial and other factors. Type A behavior pattern was measured by 12 questions. Significant coronary stenosis was defined when a 75% or greater luminal narrowing occurred at one or more major coronary arteries or 50% or greater narrowing occurred at the left main artery. Gensini's score also was calculated. Logistic regression analysis was used to calculate odds ratios and 95% confidence intervals with adjustment for traditional coronary risk factors and the presence of a job. Global Type A behavior pattern showed no material association with the severity of coronary atherosclerosis assessed by both Gensini's score and the presence of significant coronary stenosis. However, its subcomponents, enthusiasm and competitiveness, were positively related to the severity of coronary atherosclerosis, whereas self-confidence and perfectionism were negatively related. These findings suggest overall a null association between global Type A and coronary atherosclerosis as well as the presence of toxic or beneficial components of Type A behaviors in Japanese women.
• Asymmetric homogeneous reduction of dehydropeptides
  作者：S. El-Baba、J.M. Nuzillard、J.C. Poulin、H.B. Kagan

  DOI：10.1016/s0040-4020(01)87539-6

  日期：1986.1