4-(2-Diethoxyphosphoryl-2-fluoroethyl)phenol | 209120-16-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(2-Diethoxyphosphoryl-2-fluoroethyl)phenol
• CAS: 209120-16-1
• 化学式: C₁₂H₁₈FO₄P
• 分子量: 276.245
• InChiKey: BZTJYQGWQJHJNL-UHFFFAOYSA-N

物化性质

• 沸点：
  396.275±42.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.204±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(2-Diethoxyphosphoryl-2-fluoroethyl)phenol 在 碘代三甲硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 [1-Fluoro-2-(4-hydroxyphenyl)ethyl]phosphonic acid
  参考文献：
  名称：

  Synthesis of arylalkylmonofluorophosphonates as myo-inositol monophosphatase ligands

  摘要：

  Arylalkylmonofluorophosphonates were prepared by condensation of arylalkylaldehydes with the lithium salt of diethyl 1-fluoro-1-(trimethylsilyl)-methylphosphonate. Reduction and hydrolysis sequences gave the final products. These compounds do not inhibit the myo-inositol monophosphatase. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00674-1
• 作为产物：
  描述：

  4-[(4-甲氧基苯基)甲氧基]苯甲醛 在 palladium on activated charcoal 氢气 、 三溴化硼 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， -78.0~25.0 ℃ 、506.62 kPa 条件下， 反应 28.0h， 生成 4-(2-Diethoxyphosphoryl-2-fluoroethyl)phenol
  参考文献：
  名称：

  Synthesis of arylalkylmonofluorophosphonates as myo-inositol monophosphatase ligands

  摘要：

  Arylalkylmonofluorophosphonates were prepared by condensation of arylalkylaldehydes with the lithium salt of diethyl 1-fluoro-1-(trimethylsilyl)-methylphosphonate. Reduction and hydrolysis sequences gave the final products. These compounds do not inhibit the myo-inositol monophosphatase. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00674-1

文献信息

• Synthesis of arylalkylmonofluorophosphonates as myo-inositol monophosphatase ligands
  作者：Laurent Schmitt、Nukhet Cavusoglu、Bernard Spiess、Gilbert Schlewer

  DOI：10.1016/s0040-4039(98)00674-1

  日期：1998.6

  Arylalkylmonofluorophosphonates were prepared by condensation of arylalkylaldehydes with the lithium salt of diethyl 1-fluoro-1-(trimethylsilyl)-methylphosphonate. Reduction and hydrolysis sequences gave the final products. These compounds do not inhibit the myo-inositol monophosphatase. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.