hydroxyethylhydrazine | 100033-50-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: hydroxyethylhydrazine
• 英文别名: hydrazinoethanol；1-hydrazinylethanol
• CAS: 100033-50-9
• 化学式: C₂H₈N₂O
• 分子量: 76.0983
• InChiKey: VTIRNZBEJBPYCV-UHFFFAOYSA-N

物化性质

• 沸点：
  227.1±23.0 °C(Predicted)
• 密度：
  1.058±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,5-二氯邻苯二甲酸酐 、 hydroxyethylhydrazine 以 溶剂黄146 为溶剂， 生成 N-(hydroxyethylamino)-4,5-dichloronaphthalimide
  参考文献：
  名称：

  N-Acylaminonaphthalimides

  摘要：

  式为：##STR1##的化合物，其中一个R与另一个R相同或不同，且每个R均为烷基，羟基烷基，烷氧基烷基，卤代烷基，环烷基，芳基烷基，芳基，N，N-二烷基氨基烷基或季铵化的N，N-二烷基氨基烷基；A为##STR2##或##STR3##；R.sup.1为氢，取代或未取代的烷基，环烷基，芳基烷基，芳基或杂环芳基；B为--CH.dbd.CH--，--CCl.dbd.CH--，--CCl.dbd.CCl--，--CH.dbd.CBr--，--CH.sub.2--CH.sub.2--，1,2-苯基，1,8-萘基或1,2-苯基或1,8-萘基，其中带有氯，溴，甲氧基或乙氧基作为取代基；T为酰基。这些化合物非常适用于光亮增白剂，特别是用于聚酯和聚酯棉混纺物。

  公开号：

  US04139532A1
• 作为试剂：
  描述：

  1,4-二羟基蒽醌 在 4 A molecular sieve 、 溶剂黄146 、 hydroxyethylhydrazine 作用下， 以 various solvent(s) 为溶剂， 反应 2.0h， 以10%的产率得到1,4-二羟基-2-氨基-9,10-蒽二酮
  参考文献：
  名称：

  2-Amination of quinizarin via Michael addition of hydrazines or amines

  摘要：

  DOI：

  10.1021/jo00058a045

文献信息

• Isoquinoline compounds and medicinal use thereof
  申请人：Fujio Masakazu

  公开号：US20060094743A1

  公开（公告）日：2006-05-04

  The present invention relates to an isoquinoline compound represented by the following formula (I) or (II), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction.

  本发明涉及一种由以下式(I)或(II)表示的异喹啉化合物，其光学活性形式，其药学上可接受的盐，其水加合物，其水合物和其溶剂化物，以及一种含有该化合物的用于预防和/或治疗由多聚(ADP-核糖)聚合酶过度反应引起的疾病的药剂，以及一种含有该化合物的多聚(ADP-核糖)聚合酶抑制剂。此外，该化合物对于预防和/或治疗脑梗死非常有用，特别是对于预防和/或治疗急性脑梗死。
• Process for the preparation of a cellular polyurethane
  申请人：Bayer Aktiengesellschaft

  公开号：US04500656A1

  公开（公告）日：1985-02-19

  The present invention relates to a process for the preparation of a cellular polyurethane by the reaction of (A) a polyisocyanate with (B) an isocyanate reactive component containing (1) at least one component having a molecular weight of about 60-2000 and a functionality of 2 to 8, containing isocyanate reactive groups, (2) optionally at least one component having a molecular weight of about 2000 to 12,000 and a functionality of 2 to 8 containing isocyanate reactive groups. (3) about 0.1 to 30 parts, based on 100 parts of (B1)+(B2), of a liquid adduct of an amine and carbon dioxide, and (4) optionally water, blowing agents, foam stabilizers, catalysts and other auxiliary agents and additives, characterized in that the liquid adduct of amine and carbon dioxide is liquid at 20.degree. C., optionally contains water, and is an adduct of carbon dioxide and an amine having at least one amino group and containing at least one primary, secondary or tertiary hydroxyl group, which amine may be solid or liquid at 20.degree. C.

  本发明涉及一种通过(A)聚异氰酸酯与(B)含有异氰酸酯反应基团的异氰酸酯反应性组分反应制备泡沫聚氨酯的方法，其中(B)包含：(1)至少一种分子量约为60-2000、具有2至8个反应性基团、含有异氰酸酯反应性基团的组分；(2)可选地，至少一种分子量约为2000-12000、具有2至8个反应性基团、含有异氰酸酯反应性基团的组分；(3)约0.1至30份，基于100份(B1)+(B2)，的一种胺和二氧化碳的液态加合物；(4)可选的水、发泡剂、泡沫稳定剂、催化剂和其他辅助剂和添加剂。其中，胺和二氧化碳的液态加合物在20°C下为液态，可选地含有水，并且是二氧化碳和至少具有一个氨基且含有至少一个一级、二级或三级羟基的胺的加合物，该胺可以在20°C下为固体或液体。
• Tricyclic pyrrole or pyrazole derivative
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US06245796B1

  公开（公告）日：2001-06-12

  A tricyclic pyrrole or pyrazole derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof, which shows strong affinity and selectivity for the 5-HT2C receptor and is useful for the treatment of central nervous system diseases such as sexual disorders, eating disorders, anxiety, depression and sleeping disorders. (In the above formula, each symbol means as follows; Y ring: an unsaturated five-membered ring which may have 1 to 3 of one or more types of hetero atom(s) each selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom or an unsaturated six-membered ring having 1 or 2 nitrogen atom(s), X: a bond or a carbon atom, a double bond or a single bond, V: a nitrogen atom or a group represented by a formula CH, and A: a straight or branched lower alkylene group which may be substituted with a halogen atom or a cycloalkyl group).

  以下是一种三环吡咯或吡唑衍生物，由下列通式（I）表示，或其药学上可接受的盐，该化合物对5-HT2C受体表现出强烈的亲和力和选择性，可用于治疗中枢神经系统疾病，如性功能障碍、进食障碍、焦虑、抑郁和睡眠障碍。（在上述公式中，每个符号的含义如下：Y环：一种不饱和的五元环，可以具有1至3个来自氮原子、氧原子和硫原子组成的异原子，或具有1或2个氮原子的不饱和六元环，X：一种键或碳原子，双键或单键，V：一种氮原子或由CH公式表示的基团，A：一种直链或支链低级烷基基团，可以被卤素原子或环烷基基团取代。）
• Heterocyclic Compounds as Pesticides
  申请人：Bretschneider Thomas

  公开号：US20110212949A1

  公开（公告）日：2011-09-01

  The present application relates to the use of heterocyclic compounds, some of which are known, for controlling animal pests, including arthropods and in particular insects, furthermore to novel heterocyclic compounds and to processes for their preparation.

  本申请涉及使用杂环化合物（其中一些已知）来控制动物害虫，包括节肢动物，特别是昆虫，此外还涉及新型杂环化合物和其制备方法。
• Heterocyclic compounds as pesticides
  申请人：Bretschneider Thomas

  公开号：US08809547B2

  公开（公告）日：2014-08-19

  The present application relates to the use of heterocyclic compounds, some of which are known, for controlling animal pests, including arthropods and in particular insects, furthermore to novel heterocyclic compounds and to processes for their preparation.

  本申请涉及使用杂环化合物（其中一些已知）来控制动物害虫，包括节肢动物，特别是昆虫，此外还涉及新型杂环化合物和其制备方法。