3-(2-甲氧基乙氧基)丙烷-1,2-二醇 | 84131-01-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 中文名称: 3-(2-甲氧基乙氧基)丙烷-1,2-二醇
• 英文名称: 3-(2-methoxyethoxy)-1,2-propanediole
• 英文别名: 3-(2-Methoxyethoxy)-1,2-propanediol；(R)(S)-4,7-dioxy-1,2-octanediol；3-(2-Methoxyethoxy)propane-1,2-diol
• CAS: 84131-01-1
• 化学式: C₆H₁₄O₄
• 分子量: 150.175
• InChiKey: MTVRYEOLUOHZHC-UHFFFAOYSA-N

物化性质

• 沸点：
  80-81 °C(Press: 14 Torr)
• 密度：
  1.106±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  四乙二醇二对甲苯磺酸酯 、 3-(2-甲氧基乙氧基)丙烷-1,2-二醇 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以61%的产率得到2-<(2-Methoxyethoxy)methyl>-15-crown-5
  参考文献：
  名称：

  Crown cation complex effects. 22. Enhancement of cation binding in lariat ethers bearing a methyl group at the quaternary, pivot carbon atom

  摘要：

  DOI：

  10.1021/jo00156a018
• 作为产物：
  描述：

  2-甲氧基乙基缩水甘油醚 在 高氯酸 、 水 作用下， 以39%的产率得到3-(2-甲氧基乙氧基)丙烷-1,2-二醇
  参考文献：
  名称：

  Crown cation complex effects. 22. Enhancement of cation binding in lariat ethers bearing a methyl group at the quaternary, pivot carbon atom

  摘要：

  DOI：

  10.1021/jo00156a018

文献信息

• NANOPARTICLE COMPOSITION AND ASSOCIATED METHODS THEREOF
  申请人：Hay Bruce Allan

  公开号：US20120156141A1

  公开（公告）日：2012-06-21

  A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.

  提供了一种纳米颗粒组合物，其中该组合物包括纳米颗粒金属氧化物；以及包含至少两个磷酸酯基团的磷酸化多元醇。该多元醇包括从聚乙烯醚基团、聚丙烯醚基团、聚丁烯醚基团和两种或两种以上前述亲水基团的组合中选择的一个或多个亲水基团。还提供了一种制备纳米颗粒组合物的方法。本发明提供的纳米颗粒组合物可用作医学成像技术中的对比剂，如X射线和磁共振成像。
• DIAGNOSTIC AGENT COMPOSITION AND ASSOCIATED METHODS THEREOF
  申请人：Hay Bruce Allan

  公开号：US20120156142A1

  公开（公告）日：2012-06-21

  A diagnostic agent composition is provided which comprises a nanoparticle composition and a pharmaceutically acceptable carrier or excipient. The nanoparticle composition comprises a nanoparticulate metal oxide and a phosphorylated polyol, wherein the phosphorylated polyol comprises at least two phosphate groups and one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. The disclosure provides detailed guidance on methods of making and using such diagnostic agent compositions. The diagnostic agent compositions provided by the present invention are useful as contrast agents for medical diagnostic imaging techniques such as magnetic resonance (MR) imaging and X-ray imaging. The diagnostic agent composition may be administered to a subject via a variety of techniques, among them injection, inhalation, and ingestion.

  提供了一种诊断试剂组合物，包括纳米颗粒组合物和药用可接受的载体或赋形剂。纳米颗粒组合物包括纳米颗粒金属氧化物和磷酸化多元醇，其中磷酸化多元醇包括至少两个磷酸酯基团和一个或多个亲水基团，所述亲水基团选自聚乙二醚基团、聚丙二醚基团、聚丁二醚基团以及两种或两种以上的前述亲水基团的组合。该披露提供了制备和使用此类诊断试剂组合物的详细指导。本发明提供的诊断试剂组合物可用作医学诊断成像技术的对比剂，如磁共振（MR）成像和X射线成像。诊断试剂组合物可以通过多种技术向受试者施用，其中包括注射、吸入和口服。
• Thermoplastic resin composition superior in transparency and antistatic property
  申请人：TEIJIN LIMITED

  公开号：EP0759459A2

  公开（公告）日：1997-02-26

  A thermoplastic resin composition having transparency and antistatic properties, comprising 100 parts by weight of a thermoplastic resin (A) having a refractive index of 1.52 to 1.61 and a haze of 40 or less, and 5 to 40 parts by weight of a polyether ester (B) which has a sulfonate group and a polyalkylene oxide group, and is substantially immiscible with the thermoplastic resin (A), the difference in refractive index between the thermoplastic resin (A) and the polyether ester (B) being 0.04 or less. The thermoplastic resin composition has a haze of 40 % or less and a surface resistivity of 1x1010 to 1x1014 ohm/square.

  一种具有透明度和抗静电性能的热塑性树脂组合物，包括 100 重量份的热塑性树脂（A），其折射率为 1.52 至 1.61，雾度为 40 或以下；以及 5 至 40 重量份的聚醚酯（B），其具有磺酸基和聚环氧烷基，且与热塑性树脂（A）基本不相溶，热塑性树脂（A）和聚醚酯（B）之间的折射率差为 0.04 或以下。热塑性树脂组合物的雾度为 40% 或以下，表面电阻率为 1x1010 至 1x1014 欧姆/平方。
• Crown cation complex effects. 20. Syntheses and cation binding properties of carbon-pivot lariat ethers
  作者：Dennis M. Dishong、Craig J. Diamond、Michael I. Cinoman、George W. Gokel

  DOI：10.1021/ja00341a045

  日期：1983.2
• Chiellini, Emo; Nieri, Paolo; Galli, Giancarlo, Molecular Crystals and Liquid Crystals (1969-1991), 1984, vol. 113, p. 213 - 224
  作者：Chiellini, Emo、Nieri, Paolo、Galli, Giancarlo

  DOI：——

  日期：——