7-Nitro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | 765953-94-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 7-Nitro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione
• 英文别名: 7-nitro-3,4-dihydro-1H-1-benzazepine-2,5-dione
• CAS: 765953-94-4
• 化学式: C₁₀H₈N₂O₄
• 分子量: 220.185
• InChiKey: BELWBWYKQFESFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  92
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-Nitro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 0.33h， 以65%的产率得到7-Nitro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione 5-oxime
  参考文献：
  名称：

  A Facile Synthesis of 1,3,4,6-Tetrahydro-1,6-benzodiazocine-2,5-diones

  摘要：

  1,3,4,6-Tetrahydro-1,6-benzodiazocine-2,5-diones were synthesized from 3,4-dihydro-1H-benzazepine-2,5-diones through the corresponding oximes using simple reagents and procedures.

  DOI：

  10.1023/b:rujo.0000036082.67132.22
• 作为产物：
  描述：

  4-(4-硝基苯胺基)-4-氧代丁酸 在 PPA 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 以81%的产率得到7-Nitro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione
  参考文献：
  名称：

  A Facile Synthesis of 1,3,4,6-Tetrahydro-1,6-benzodiazocine-2,5-diones

  摘要：

  1,3,4,6-Tetrahydro-1,6-benzodiazocine-2,5-diones were synthesized from 3,4-dihydro-1H-benzazepine-2,5-diones through the corresponding oximes using simple reagents and procedures.

  DOI：

  10.1023/b:rujo.0000036082.67132.22

文献信息

• Enzyme modulators and treatments
  申请人：Flynn L. Daniel

  公开号：US20070078121A1

  公开（公告）日：2007-04-05

  Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, immunological disorders, hyperproliferative diseases, cancer, and diseases characterized by hyper-vascularization are provided. In a preferred embodiment, modulation of the activation state of kinases, including p38 kinase protein, abl kinase protein, bcr-abl kinase protein, braf kinase protein, VEGFR kinase protein, or PDGFR kinase protein, comprises the step of contacting said kinase protein with the novel compounds.

  提供了新型化合物及其使用方法，用于治疗炎症性疾病、免疫性疾病、过度增生性疾病、癌症以及以高血管化为特征的疾病。在一种优选实施方式中，调节激酶的激活状态，包括p38激酶蛋白、abl激酶蛋白、bcr-abl激酶蛋白、braf激酶蛋白、VEGFR激酶蛋白或PDGFR激酶蛋白，包括将该激酶蛋白与新型化合物接触的步骤。
• ENZYME MODULATORS AND TREATMENTS
  申请人：Flynn L. Daniel

  公开号：US20080113967A1

  公开（公告）日：2008-05-15

  Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, hyperproliferative diseases, cancer, and diseases characterized by hyper-vascularization are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein, abl kinase protein, ber-abl kinase protein, braf kinase protein, VEGFR kinase protein, or PDGFR kinase protein comprises the step of contacting said kinase protein with the novel compounds.

  本发明提供了新的化合物及其使用方法，用于治疗炎症状况、过度增殖性疾病、癌症和以高血管化为特征的疾病。在优选实施例中，调节p38激酶蛋白、abl激酶蛋白、ber-abl激酶蛋白、braf激酶蛋白、VEGFR激酶蛋白或PDGFR激酶蛋白的激活状态，包括将该激酶蛋白与新的化合物接触的步骤。
• US8163756B2
  申请人：——

  公开号：US8163756B2

  公开（公告）日：2012-04-24
• A Facile Synthesis of 1,3,4,6-Tetrahydro-1,6-benzodiazocine-2,5-diones
  作者：D. V. Jarikote、V. G. Pawar、S. R. Bhusare、R. V. Hangarge、Y. B. Vibhute、R. P. Pawar

  DOI：10.1023/b:rujo.0000036082.67132.22

  日期：2004.4

  1,3,4,6-Tetrahydro-1,6-benzodiazocine-2,5-diones were synthesized from 3,4-dihydro-1H-benzazepine-2,5-diones through the corresponding oximes using simple reagents and procedures.