allyl 2-methyl-4-pentenoate | 1092695-28-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: allyl 2-methyl-4-pentenoate
• 英文别名: Prop-2-enyl 2-methylpent-4-enoate
• CAS: 1092695-28-7
• 化学式: C₉H₁₄O₂
• 分子量: 154.209
• InChiKey: ZXVGLCDAPKHWMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  allyl 2-methyl-4-pentenoate 在 aluminum tris(2,6-diphenylphenoxide) 、 Hoveyda-Grubbs catalyst second generation 作用下， 以 二氯甲烷 为溶剂， 反应 8.25h， 以80%的产率得到2-methyl-4,5-dehydro ε-lactone
  参考文献：
  名称：

  Substrate Encapsulation: An Efficient Strategy for the RCM Synthesis of Unsaturated ϵ-Lactones

  摘要：

  A facile substrate-encapsulated RCM-based synthesis of 7-membered lactones is reported. Coordination of the alpha,omega-dienyl ester precursor to the bulky Lewis acid (LA) aluminum tris(2,6-diphenylphenoxide) (ATPH) provides a protective extended steric pocket to the olefin moieties, thereby favoring intramolecular RCM over intermolecular ADMET oligomerization. The LA-encapsulated esters undergo ring-closure in the presence of Ru-based olefin metathesis catalysts to give previously difficult-to-access 7-membered beta,gamma- and gamma,delta-unsaturated lactones in good yields.

  DOI：

  10.1021/ol8022227
• 作为产物：
  描述：

  2-methyl-4-pentenoyl chloride 、 烯丙醇 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 allyl 2-methyl-4-pentenoate
  参考文献：
  名称：

  Substrate Encapsulation: An Efficient Strategy for the RCM Synthesis of Unsaturated ϵ-Lactones

  摘要：

  A facile substrate-encapsulated RCM-based synthesis of 7-membered lactones is reported. Coordination of the alpha,omega-dienyl ester precursor to the bulky Lewis acid (LA) aluminum tris(2,6-diphenylphenoxide) (ATPH) provides a protective extended steric pocket to the olefin moieties, thereby favoring intramolecular RCM over intermolecular ADMET oligomerization. The LA-encapsulated esters undergo ring-closure in the presence of Ru-based olefin metathesis catalysts to give previously difficult-to-access 7-membered beta,gamma- and gamma,delta-unsaturated lactones in good yields.

  DOI：

  10.1021/ol8022227

文献信息

• Fluorinated methyl beta-alanine derivatives, their preparation and pharmaceutical compositions containing them
  申请人：MERRELL TORAUDE ET COMPAGNIE

  公开号：EP0024965A1

  公开（公告）日：1981-03-11

  Beta-monofluoromethyl beta-alanine, beta-difluoromethyl beta-alanine and pharmaceutically acceptable esters and amides derived from the acid group, amides and urethanes derived from the amine group, lactams and salts thereof are novel compounds which inhibit y-aminobutyric acid transaminase (GABA-T).

  Beta-monofluoromethyl beta-alanine、beta-difluoromethyl beta-alanine以及由酸基衍生的药学上可接受的酯和酰胺、由胺基衍生的酰胺和氨基甲酸乙酯、内酰胺及其盐类是新型化合物，可抑制y-氨基丁酸转氨酶（GABA-T）。
• Alpha Helical Mimics, Their Uses and Methods For Their Production
  申请人：Fairlie David P.

  公开号：US20080242598A1

  公开（公告）日：2008-10-02

  This invention discloses short chain peptides that have been constrained to adopt an alpha helical conformation and their use as alpha helical scaffolds for directing amino acid side chains into positions analogous to those found in longer chain alpha helical peptides and for attaching peptidic or non-peptidic appendages in order to mimic side chains of longer alpha helical peptides. More particularly the invention discloses alpha helical cyclic pentapeptides and their use as alpha helical scaffolds or macrocyclic alpha helical modules, either alone, or within longer chain peptides or attached to other macrocyclic peptides or attached to non-peptidic structures, for the purpose of mimicking naturally occurring peptides or proteins, and as agonists or antagonists of the biological activity of naturally-occurring peptides or proteins or for the preparation of new materials.
• US3907718A
  申请人：——

  公开号：US3907718A

  公开（公告）日：1975-09-23
• US3976801A
  申请人：——

  公开号：US3976801A

  公开（公告）日：1976-08-24
• US3966799A
  申请人：——

  公开号：US3966799A

  公开（公告）日：1976-06-29