2-[2-(4-Methylphenoxy)ethyl]-1,3-dioxolane | 1225533-42-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[2-(4-Methylphenoxy)ethyl]-1,3-dioxolane
• 英文别名: 2-[2-(4-methylphenoxy)ethyl]-1,3-dioxolane
• CAS: 1225533-42-5
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: PMAROEIYABFBGF-UHFFFAOYSA-N

物化性质

• 沸点：
  309.2±22.0 °C(Predicted)
• 密度：
  1.078±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[2-(4-Methylphenoxy)ethyl]-1,3-dioxolane 在 ammonium cerium (IV) nitrate 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 0.5h， 以78%的产率得到6-甲基-4-苯并二氢呋喃-4-酮
  参考文献：
  名称：

  The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction

  摘要：

  The enantiospecific synthesis of chromanes and isochromanes obtained from an intramolecular Nicholas cyclisation reaction is discussed. During the course of this study we observed the formation of chroman-4-ones from a CAN deprotection step of a dioxolane and this is also discussed. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.05.112

文献信息

• The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction
  作者：Elizabeth Tyrrell、Khatebeh Mazloumi、Donatella Banti、Paulina Sajdak、Alex Sinclair、Adam Le Gresley

  DOI：10.1016/j.tetlet.2012.05.112

  日期：2012.8

  The enantiospecific synthesis of chromanes and isochromanes obtained from an intramolecular Nicholas cyclisation reaction is discussed. During the course of this study we observed the formation of chroman-4-ones from a CAN deprotection step of a dioxolane and this is also discussed. (c) 2012 Elsevier Ltd. All rights reserved.