(R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide
中文名称
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中文别名
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英文名称
(R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide
英文别名
(R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-trimethyl-1,1-dioxo-1,2,5,6-tetrahydro-1lambda6-[1,4]thiazin-3-ylamine；(3R)-3-(5-bromo-2-fluorophenyl)-3,6,6-trimethyl-1,1-dioxo-2H-1,4-thiazin-5-amine
CAS
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化学式
C13H16BrFN2O2S
mdl
——
分子量
363.251
InChiKey
KLNCEHAORDZYFZ-ZDUSSCGKSA-N
BEILSTEIN
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EINECS
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
计算性质
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辛醇/水分配系数(LogP)：1.5
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重原子数：20
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可旋转键数：1
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环数：2.0
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sp3杂化的碳原子比例：0.46
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拓扑面积：80.9
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氢给体数：1
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氢受体数：4
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 —— 2-[(2R)-2-amino-2-(5-bromo-2-fluorophenyl)propyl]sulfonyl-2-methylpropanenitrile 1403468-21-2 C13H16BrFN2O2S 363.251 —— (R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-trimethyl-1,1-dioxo-1λ6-thiomorpholin-3-one —— C13H15BrFNO3S 364.235 —— (R)-N-[(2R)-2-(5-bromo-2-fluorophenyl)-1-(2-cyanopropan-2-ylsulfonyl)propan-2-yl]-2-methylpropane-2-sulfinamide 1403468-20-1 C17H24BrFN2O3S2 467.424 —— (R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-trimethyl-1,1-dioxo-1λ6-thiomorpholin-3-thione —— C13H15BrFNO2S2 380.302 —— tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)thio)propan-2-yl)carbamate 1600511-35-0 C17H22BrFN2O2S 417.342 -
下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— (R)-5-amino-3-(2-fluoro-5-hydroxyphenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide 1600512-07-9 C13H17FN2O3S 300.354 —— (R)-5-(5-amino-2-fluoro-phenyl)-2,2,5-trimethyl-1,1-dioxo-1,2,5,6-tetrahydro-1λ6-[1,4]thiazin-3-ylamine —— C13H18FN3O2S 299.369 —— US9181236, Table A, 31 —— C15H18BrFN2O2S 389.289 —— 3-[3-[(3R)-5-amino-3,6,6-trimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-4-fluorophenyl]benzonitrile 1403464-88-9 C20H20FN3O2S 385.462 —— 4-(3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenoxy)benzonitrile 1600507-56-9 C20H20FN3O3S 401.462 —— (R)-N-(5-(5-bromo-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)benzamide 1600512-04-6 C20H20BrFN2O3S 467.359 —— (5R)-5-(5-(4-chloro-3-ethylphenoxy)-2-fluorophenyl)-2,2,5-trimethyl-5,6-dihydro-2H-1,4-thiazin-3-amine 1,1-dioxide 1600507-63-8 C21H24ClFN2O3S 438.951 —— (5R)-5-(2-fluoro-5-(1-naphthalenylsulfanyl)phenyl)-2,2,5-trimethyl-5,6-dihydro-2H-1,4-thiazin-3-amine 1,1-dioxide 1600507-29-6 C23H23FN2O2S2 442.578 —— (R)-tert-butyl (5-(5-amino-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)carbamate —— C18H26FN3O4S 399.487 —— (2S,3R)-5-amino-3-(5-amino-2-fluorophenyl)-2-fluoro-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide 1600508-24-4 C13H17F2N3O2S 317.36 —— (R)-N-(5-(2-fluoro-5-hydroxyphenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)benzamide 1600512-06-8 C20H21FN2O4S 404.462 —— (R)-5-amino-3-(5-(((4-chloro-1-(difluoromethyl)-1H-pyrazol-3-yl)methyl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide 1600507-71-8 C18H21ClF3N5O2S 463.911 —— tert-butyl ((5R,6S)-5-(5-bromo-2-fluorophenyl)-6-fluoro-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)carbamate 1600511-50-9 C18H23BrF2N2O4S 481.358 —— (R)-methyl 3-(5-((tert-butoxy carbonyl)amino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorobenzoate 1600512-50-2 C20H27FN2O6S 442.509 —— N-(3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-2-methoxy-5-quinoxalinamine 1600507-21-8 C22H24FN5O3S 457.529 —— tert-butyl ((5R,6R)-5-(5-bromo-2-fluorophenyl)-6-(2-hydroxyethyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)carbamate 1600512-88-6 C20H28BrFN2O5S 507.421 —— tert-butyl ((5R,6R)-6-allyl-5-(5-bromo-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)carbamate 1600512-87-5 C21H28BrFN2O4S 503.433 —— (R)-5-amino-3-(2-fluoro-5-((2-methylbenzo[d]thiazol-4-yl)amino)phenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide 1600507-69-4 C21H23FN4O2S2 446.57 —— (R)-5-amino-3-(5-(((6-chloro-3-methylimidazo[1,2-a]pyridin-2-yl)methyl)amino)-2-fluorophenyl)-3,6,6-trimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide 1600508-12-0 C22H25ClFN5O2S 477.99 —— (R)-N-(3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide 1600507-70-7 C18H19ClF3N5O3S 477.895 —— N-(3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-(difluoromethoxy)-3-methyl-2-pyridinecarboxamide 1600508-04-0 C21H23F3N4O4S 484.499 —— 2-((2R,3R)-3-(5-bromo-2-fluorophenyl)-5-((tert-butoxycarbonyl)-amino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-2-yl)-ethyl methanesulfonate 1600512-89-7 C21H30BrFN2O7S2 585.513 —— N-(3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-3-bromopyrido[2,3-d]pyridazin-8-amine 1600511-18-9 C20H20BrFN6O2S 507.386 —— (R)-N-(5-(2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)benzamide 1600512-05-7 C26H32BFN2O5S 514.426 —— N-(3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-3-methoxy-1,7-naphthyridin-8-amine 1600506-73-7 C22H24FN5O3S 457.529 —— tert-butyl ((5R,6S)-5-(5-amino-2-fluorophenyl)-6-fluoro-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)carbamate 1600512-60-4 C18H25F2N3O4S 417.477 ——