甲基丙烯酸2-哌啶乙基酯 | 19416-48-9

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 甲基丙烯酸2-哌啶乙基酯
• 英文名称: 2-(pentamethyleneimino)ethyl methacrylate
• 英文别名: piperidinylethyl methacrylate；Methacrylsaeure-(2-piperidino-ethylester)；β-(N-Piperidyl)-ethylmethacrylat；Methacrylsaeure-(2-piperidino-aethylester)；2-piperidin-1-ylethyl methacrylate；2-Piperidinoethyl-methacrylat；piperidinethyl methacrylate；Methacrylic acid 2-piperidinoethyl ester；2-piperidin-1-ylethyl 2-methylprop-2-enoate
• CAS: 19416-48-9
• 化学式: C₁₁H₁₉NO₂
• mdl: MFCD00080627
• 分子量: 197.277
• InChiKey: GMTJKMKNOIUGPG-UHFFFAOYSA-N

物化性质

• 沸点：
  183-185 °C(Press: 10 Torr)
• 密度：
  1.5210 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.727
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  甲基丙烯酸2-哌啶乙基酯 、 碘甲烷 以75%的产率得到
  参考文献：
  名称：

  KASYMOV SH. K.; ABDUVAXABOV A. A.; ASLANOV X. A.; SADYKOV A. A., UZSSR FANLAR AKAD. DOKL., DOKL. AN UZSSR , 1976, HO 9, 38-40

  摘要：

  DOI：
• 作为产物：
  描述：

  N-羟乙基哌啶 以65%的产率得到
  参考文献：
  名称：

  KASYMOV SH. K.; ABDUVAXABOV A. A.; ASLANOV X. A.; SADYKOV A. A., UZSSR FANLAR AKAD. DOKL., DOKL. AN UZSSR , 1976, HO 9, 38-40

  摘要：

  DOI：

文献信息

• Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells
  作者：Kejin Zhou、Yiguang Wang、Xiaonan Huang、Katherine Luby-Phelps、Baran D. Sumer、Jinming Gao

  DOI：10.1002/anie.201100884

  日期：2011.6.27

  Switch it up: Tunable, pH‐responsive nanoparticles can be selectively activated in different endocytic compartments. At high pH values, micelle formation (see picture, left) quenches fluorescence by Förster resonance energy transfer. The micelles disassemble at low pH values, leading to fluorescence emission. This nonlinear on/off nanoplatform offers many exciting opportunities in diagnostic imaging

  切换：可调节的、pH 响应性纳米颗粒可以在不同的内吞隔室中被选择性激活。在高 pH 值下，胶束形成（见左图）通过 Förster 共振能量转移淬灭荧光。胶束在低 pH 值下分解，导致荧光发射。这种非线性开/关纳米平台在诊断成像和药物输送应用中提供了许多令人兴奋的机会。
• A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy
  作者：Qian Shen、Lei Xu、Rong Li、Guang Wu、Senlin Li、Phei Er Saw、Yusheng Zhou、Xiaoding Xu

  DOI：10.1039/d0cc07808e

  日期：——

  A robust TME pH-responsive nanoplatform was herein developed. This nanoplatform could significantly improve intracellular delivery of cytotoxic saporin to achieve an effective inhibition of tumor growth of breast cancer.

  在这里开发了一种强大的TME pH响应型纳米平台。这种纳米平台可以显著提高细胞内毒性剂萨波林的输送，从而有效抑制乳腺癌肿瘤生长。
• Functionalized Photoreactive Compounds
  申请人：Cherkaoui Mohammed Zoubair

  公开号：US20080274304A1

  公开（公告）日：2008-11-06

  The present invention concerns functionalized photoreactive compounds of formula (I), that are particularly useful in materials for the alignment of liquid crystals. Due to the adjunction of an electron withdrawing group to specific molecular systems bearing an unsaturation directly attached to two unsaturated ring systems, exceptionally high photosensitivities, excellent alignment properties as well as good mechanical robustness could be achieved in materials comprising said functionalized photoreactive compounds of the invention.

  本发明涉及式(I)的官能化光反应化合物，特别适用于液晶对准材料。由于在特定分子系统中的不饱和键直接连接到两个不饱和环系统上附加了一个电子受体基团，因此在包含本发明的这些官能化光反应化合物的材料中可以实现异常高的光敏性、优异的对准性能以及良好的机械稳健性。
• [EN] CYANOSTILBENES<br/>[FR] CYANOSTILBÈNES
  申请人：ROLIC AG

  公开号：WO2014191292A1

  公开（公告）日：2014-12-04

  The present invention relates to novel compounds that are particularly useful for the alignment, especially photoalignment, of slave material, especially liquid crystals for optical or electro-optical applications, such as security applications, liquid crystal devices or optical or electro-optical films.

  本发明涉及一种新型化合物，特别适用于用于光学或电光应用的从材料，尤其是液晶的定向，特别是光定向，如安全应用、液晶器件或光学或电光薄膜。
• PROCESS FOR PREPARING (METH)ACRYLIC ESTERS OF N,N-SUBSTITUTED AMINO ALCOHOLS
  申请人：Bette Virginie

  公开号：US20120077977A1

  公开（公告）日：2012-03-29

  The present invention relates to a process for preparing (meth)acrylic esters (F) of N,N-substituted amino alcohols, by transesterifying N,N-substituted amino alcohols (I) in which Y and Z are each independently C 1 -C 20 -alkyl, C 3 -C 15 -cycloalkyl, aryl, or Y and Z together with the nitrogen atom connecting them form a 5- to 9-membered saturated heterocyclic radical which optionally has oxygen, sulfur, nitrogen or C 1 -C 4 -alkyl-substituted nitrogen as a further heteroatom, and X is C 2 -C 20 -alkylene which may be interrupted by 1 to 10 nonadjacent oxy groups and/or unsubstituted or methoxy-substituted C 1 -C 4 -alkylimino groups, or a C 3 -C 15 -cycloalkylene, with at least one (meth)acrylic ester (D) in the presence of at least one heterogeneous catalyst (K), wherein the heterogeneous catalyst (K) is used without any further solvent and the content of polymerization inhibitors in the reaction mixture is <450 ppm, and to the use of the (meth)acrylic esters (F) of N,N-substituted amino alcohols.

  本发明涉及一种制备N,N-取代氨基醇的（甲基）丙烯酸酯（F）的方法，通过在异相催化剂（K）的存在下，将N,N-取代氨基醇（I）经过酯交换反应，其中Y和Z分别独立地为C1-C20烷基，C3-C15环烷基，芳基，或Y和Z与连接它们的氮原子一起形成一个5-至9-成员的饱和杂环基团，该团可选地具有氧，硫，氮或C1-C4烷基取代的氮作为进一步的杂原子，而X为C2-C20烷基，其可被1至10个非相邻氧基和/或未取代或甲氧基取代的C1-C4烷基亚胺基所中断，或为C3-C15环烷基，与至少一种（甲基）丙烯酸酯（D）反应。其中，异相催化剂（K）在无任何其他溶剂的情况下使用，反应混合物中的聚合抑制剂含量小于450 ppm，以及N,N-取代氨基醇的（甲基）丙烯酸酯（F）的用途。