oxalic acid-chloride propyl ester | 54166-91-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: oxalic acid-chloride propyl ester
• 英文别名: Oxalsaeure-chlorid-propylester；Chlorooxoacetic acid propyl ester；propyl 2-chloro-2-oxoacetate
• CAS: 54166-91-5
• 化学式: C₅H₇ClO₃
• 分子量: 150.562
• InChiKey: SPDFUQSXHXWHLI-UHFFFAOYSA-N

物化性质

• 沸点：
  207.06°C (rough estimate)
• 密度：
  1.3157 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  oxalic acid-chloride propyl ester 在 水 作用下， 生成 草酸单丙酯
  参考文献：
  名称：

  Synthesis, Crystal Structure, and Insecticidal Activity of Novel N-Alkyloxyoxalyl Derivatives of 2-Arylpyrrole

  摘要：

  Two series of novel N-alkyloxyoxalyl derivatives of 2-arylpyrrole were synthesized, and their structures were characterized by (1)H NMR spectroscopy, elemental analysis, and single-crystal X-ray diffraction analysis. The insecticidal activities of the new compounds were evaluated. The results of bioassays indicated that some of these title compounds exhibited excellent insecticidal activities, and their insecticidal activities against oriental armyworm, mosquito, and spider mite are comparable to those of the commercialized Chlorfenapyr.

  DOI：

  10.1021/jf801311h
• 作为产物：
  描述：

  Dichlor-butyloxy-essigsaeure-propylester 生成 oxalic acid-chloride propyl ester
  参考文献：
  名称：

  Ivashchenko,Ya.N.; Moshchitskii,S.D., Journal of general chemistry of the USSR, 1964, vol. 34, p. 610 - 613

  摘要：

  DOI：

文献信息

• Oxanilic acids, a new series of orally active antiallergic agents
  作者：John H. Sellstedt、Charles J. Guinosso、Albert J. Begany、Stanley C. Bell、Marvin Rosenthale

  DOI：10.1021/jm00243a014

  日期：1975.9

  antiallergic activity using the rat passive cutaneous anaphylaxis (PCA) test. Many of the oxanilic acid esters are active orally, with the most active species having an aryl 2'-carbamoyl group and a 3'-methoxy group. Hydrolysis of the ester from the oxanilic ester moiety causes a loss of oral activity.

  制备了大量的草酸苯甲酸酯和N-杂芳基草酰胺酸酯，并通过大鼠被动皮肤过敏反应（PCA）测试发现具有抗过敏活性。许多草酰苯甲酸酯具有口服活性，最活泼的物种具有芳基2'-氨基甲酰基和3'-甲氧基。酯从草酰胺酯部分水解会导致口服活性下降。
• Design, Synthesis and Insecticidal Activities of Novel<i>N</i>-Oxalyl Derivatives of Neonicotinoid Compound
  作者：Yu Zhao、Gang Wang、Yongqiang Li、Suhua Wang、Zhengming Li

  DOI：10.1002/cjoc.201090099

  日期：2010.1

  Ten novel neonicotinoid derivatives containing N‐oxalyl groups were designed and synthesized, and their structures were characterized by 1H NMR, MS, IR, elemental analysis and single crystal X‐ray diffraction analysis. The insecticidal activities of the new compounds were evaluated. The results of bioassays indicated that some of these title compounds exhibited excellent insecticidal activities.

  设计并合成了十个含有N-草酰基的新烟碱类衍生物，并通过1 H NMR，MS，IR，元素分析和单晶X射线衍射分析对它们的结构进行了表征。评价了新化合物的杀虫活性。生物测定的结果表明，这些标题化合物中的一些表现出优异的杀虫活性。
• Novel antiallergic agents. Part I: Synthesis and pharmacology of pyrimidine amide derivatives
  作者：Masakazu Ban、Hiroaki Taguchi、Takeo Katsushima、Shoichi Aoki、Akihiko Watanabe

  DOI：10.1016/s0968-0896(98)00064-9

  日期：1998.7

  We have synthesized many pyrimidine amide derivatives. Novel pyrimidine bis-glycolic amide derivatives showed moderate inhibition in the rat passive cutaneous anaphylaxis (PCA) assay by oral administration. Among these compounds, 2,4-bis(methoxyacetylamino)-6-piperidinopyrimidine (2i) exhibited significant inhibition. However the compound (2i) did not inhibit antigen-induced histamine or SRS-A release

  我们已经合成了许多嘧啶酰胺衍生物。新型嘧啶双乙醇酰胺衍生物在口服给药的大鼠被动皮肤过敏反应（PCA）分析中显示出中等抑制作用。在这些化合物中，2,4-双（甲氧基乙酰氨基）-6-哌啶子基嘧啶（2i）表现出显着的抑制作用。但是，化合物（2i）在低于10（-4）M时不抑制抗原诱导的组胺或SRS-A从豚鼠的肺碎片中释放。2i衍生物在大鼠PCA分析中也具有显着或中等活性。在酰胺PCA测定中，在酰胺羰基的α位上没有氧原子的化合物2h和没有酰胺羰基的化合物17没有显示出抑制作用。我们认为，酰胺羰基和酰胺羰基α位的氧原子均在抑制大鼠PCA反应中起重要作用。这些嘧啶双乙醇酰胺衍生物具有新颖的结构和独特的活性，表明它们可能在治疗过敏性疾病中可能有用。
• N-[2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl]oxamides as light stabilisers
  申请人：ELF ATOCHEM NORTH AMERICA, INC.

  公开号：EP0593936A1

  公开（公告）日：1994-04-27

  This invention relates to novel UV absorbers, their methods of preparation, their use in stabilizing polymers and polymers so stabilized against the degradative effects of UV light. The novel compounds of formula I are oxamides which are substituted on one or both nitrogens with a 2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl group. The 2-hydroxy-3-(2H-benzotriazol-2-yl)benzyl groups are efficient UV absorbing groups and the oxamide group contributes additional light stabilizing, heat stabilizing and metal complexing properties to the compounds. The compounds have low-volatility and are especially useful as UV stabilizers for engineering resins processed at high temperatures.

  这项发明涉及新型紫外线吸收剂，其制备方法，其在稳定聚合物中的使用以及通过紫外线光的降解作用而得到稳定的聚合物。公式I的新型化合物是氧酰胺，其在一个或两个氮上被2-羟基-3-(2H-苯并三唑-2-基)苯甲基基团取代。2-羟基-3-(2H-苯并三唑-2-基)苯甲基基团是高效的紫外线吸收基团，而氧酰胺基团则为化合物提供了额外的光稳定、热稳定和金属络合性能。这些化合物具有低挥发性，特别适用于在高温下加工的工程树脂的紫外线稳定剂。
• MODIFICATIONS OF THERAPEUTIC AGENTS FOR ENHANCED DELIVERY TO TARGET SITES
  申请人：Partikula LLC

  公开号：US20180028647A1

  公开（公告）日：2018-02-01

  Compositions of a modulator of cell metabolism, typically targeting cellular glycolysis, preferably with a targeting moiety, attached directly or indirectly to the inhibitor, or to a nanoparticle or other delivery vehicle thereof, and methods of use for treating cancer, proliferative disorders, neurodegenerative diseases, autoimmune disorders, or inflammatory diseases are provided. Pharmaceutical compositions including the targeted modulator and a pharmaceutically acceptable carrier are also provided. The pharmaceutical compositions can be administered to a subject in need thereof in an effective amount to reduce one or symptoms of the cancer, proliferative disorders, neurodegenerative diseases, autoimmune disorders, or inflammatory diseases alone or prior to or in conjunction with a further therapy such as radiotherapy.

  提供了细胞代谢调节剂的组成，通常以靶向细胞糖酵解为目标，最好带有一个靶向基团，直接或间接连接到抑制剂，或连接到纳米颗粒或其他递送载体上，并提供了用于治疗癌症、增生性疾病、神经退行性疾病、自身免疫性疾病或炎症性疾病的方法。还提供了包括靶向调节剂和药学上可接受的载体的药物组合物。这些药物组合物可以以有效剂量给需要的受试者使用，以减少癌症、增生性疾病、神经退行性疾病、自身免疫性疾病或炎症性疾病的症状之一或多个，独立使用或在放疗等进一步治疗之前或同时使用。