3-(3-吗啉-4-苯基)-5-氨基异噁唑 | 887591-31-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 3-(3-吗啉-4-苯基)-5-氨基异噁唑
• 英文名称: 3-(3-Morpholinophenyl)isoxazol-5-amine
• 英文别名: 3-(3-morpholin-4-ylphenyl)-1,2-oxazol-5-amine
• CAS: 887591-31-3
• 化学式: C₁₃H₁₅N₃O₂
• 分子量: 245.28
• InChiKey: USPFYCZKLJATSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  64.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Metalloprotease inhibitors containing a squaramide moiety
  申请人：Gege Christian

  公开号：US20080221128A1

  公开（公告）日：2008-09-11

  The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds with a squaramide or benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
• Metalloprotease inhibitors containing a heterocyclic moiety
  申请人：Gege Christian

  公开号：US20080221095A1

  公开（公告）日：2008-09-11

  The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds with a squaramide or benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
• [EN] METALLOPROTEASE INHIBITORS CONTAINING A SQUARAMIDE MOIETY<br/>[FR] INHIBITEURS DE MÉTALLOPROTÉASE CONTENANT UNE FRACTION SQUARAMIDE
  申请人：ALANTOS PHARM HOLDING

  公开号：WO2008109178A1

  公开（公告）日：2008-09-12

  [EN] The present invention relates generally to pharmaceutical agents of Formula (I) containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP 3, MMP 8 and/or MMP 13 inhibiting compounds with a squaramide or benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP 13, MMP 8 and MMP 3 inhibitors. Formula (I).
  [FR] De manière générale, l'invention concerne des agents pharmaceutiques représentés par la formule (I) qui contiennent une fraction hétérocyclique, et en particulier, des composés inhibiteurs de métalloprotéase hétérocycliques. Plus particulièrement, la présente invention fournit une nouvelle catégorie de composés inhibiteurs de MMP 3, de MMP 8 et/ou de MMP 13 hétérocycliques pourvus d'une fraction squaramide ou benzoxazinone, qui présentent une efficacité et une sélectivité accrues par rapport aux inhibiteurs de MMP 13, de MMP 8 et de MMP 3 actuellement connus. Formule (I)