1H-1,4-Benzodiazepine, 2,3,4,5-tetrahydro-4-(1-methylethyl)- | 486453-49-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 1H-1,4-Benzodiazepine, 2,3,4,5-tetrahydro-4-(1-methylethyl)-
• 英文别名: 4-propan-2-yl-1,2,3,5-tetrahydro-1,4-benzodiazepine
• CAS: 486453-49-0
• 化学式: C₁₂H₁₈N₂
• 分子量: 190.28
• InChiKey: ULXQCZLXOXWRQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Bicyclic Heterocylic Derivatives and Methods of Use
  申请人：De Lera Ruiz Manuel

  公开号：US20110130385A1

  公开（公告）日：2011-06-02

  The present invention relates to novel bicyclic heterocycle derivatives, pharmaceutical compositions comprising the bicyclic heterocycle derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. R 1 is: I, Ia, Ib ou Ic. R 2 is alkyl, alkenyl, aryl, cycloalkyl. heterocycloalkyl or heteroaryl, any of which can be optionally substituted with R 3 ; Y is —C(O)—, —S—, —S(O)—, —S(O) 2 —, —CH 2 — or —O—, such that if Y is —O— or —S—, then M is other than N and R 1 is (Ib);
• US7176195B2
  申请人：——

  公开号：US7176195B2

  公开（公告）日：2007-02-13