2-(Cyclohexylamino)-3-hydroxypropanoic acid | 915405-04-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(Cyclohexylamino)-3-hydroxypropanoic acid
• CAS: 915405-04-8
• 化学式: C₉H₁₇NO₃
• 分子量: 187.24
• InChiKey: KSKBNEPTTKVOSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• PARAKERATOSIS INHIBITOR, PORE-SHRINKING AGENT OR AGENT FOR PREVENTING/AMELIORATING ROUGH SKIN AND EXTERNAL COMPOSITION FOR SKIN
  申请人：Shiseido Company, Limited

  公开号：EP1884230A1

  公开（公告）日：2008-02-06

  The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin -inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and to further provide an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor agent, pore-shrinking agent, or rough skin preventing/amaliorating agent comprises one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof. The external composition for skin comprises the one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent.

  该发明提供了一种具有角化不全抑制、收缩毛孔或防止/改善粗糙皮肤功能的抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂，不会引起感觉刺激等安全问题，非常安全，并进一步提供了一种外用皮肤组合物，其中添加了具有上述功能的化合物。角化不全抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂包括从α-氨基酸衍生物和其盐组成的群中选择的一种、两种或更多化合物。外用皮肤组合物包括从α-氨基酸衍生物和其盐组成的群中选择的一种、两种或更多化合物，作为上述角化不全抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂。
• Parakeratosis inhibitor, pore-shrinking agent,or rough skin preventing/ameliorating agent, and external composition for skin
  申请人：Kaminuma Mikiko

  公开号：US20090215893A1

  公开（公告）日：2009-08-27

  The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin-inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and to further provide an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor agent, pore-shrinking agent, or rough skin preventing/amaliorating agent comprises one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof. The external composition for skin comprises the one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent.

  本发明提供了一种角化不全抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂，具有角化不全抑制、毛孔收缩或防止/减轻粗糙皮肤等功能，不会引起感觉刺激等安全问题，非常安全，进一步提供了一种添加了具有上述功能的化合物的皮肤外用组合物。该角化不全抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂包含从α-氨基酸衍生物和其盐的组中选择的一种、两种或更多化合物。该皮肤外用组合物包含从α-氨基酸衍生物和其盐的组中选择的一种、两种或更多化合物，作为上述角化不全抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂。
• Method for producing l-phenylalanine by fermentation
  申请人：AJINOMOTO CO., INC.

  公开号：EP0085958A2

  公开（公告）日：1983-08-17

  L-phenylalanine producing microorganisms, which have been constructed by introducing a recombinant plasmid DNA inserted with a chromosomal DNA fragment controlling the resistance to a phenylalanine-antagonist obtained from a mutant of the genus Bacillus resistant to the phenylalanine antagonist, into a recipient strain of the genus Bacillus, produce L-phenylalanine in higher yield than the mutants used as the DNA-donor or the recipient strain.

  通过将插入了控制对苯丙氨酸拮抗剂的抗性的染色体 DNA 片段的重组质粒 DNA 导入芽孢杆菌属的受体菌株，构建了生产 L-苯丙氨酸的微生物，与用作 DNA 供体或受体菌株的突变体相比，这些微生物生产 L-苯丙氨酸的产量更高。
• Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
  申请人：Les Laboratoires Servier

  公开号：EP1403275A1

  公开（公告）日：2004-03-31

  Procédé de synthèse industrielle du perindopril de formule (I) : et de ses sels pharmaceutiquement acceptables.

  式 (I) 的培哚普利及其药物可接受盐的工业合成工艺： 及其药学上可接受的盐类。
• Nouveau procédé de synthèse de dérives de l'acide (2S, 3aS, 7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylique, et application à la synthèse du perindopril
  申请人：LES LABORATOIRES SERVIER

  公开号：EP1403277A1

  公开（公告）日：2004-03-31

  Procédé de synthèse industrielle des composés de formule (I) : dans laquelle R1 représente un atome d'hydrogène ou un groupement alkyle ou benzyle, et R2 représente un groupement protecteur de la fonction amine. Application à la synthèse du pcrindopril et de ses sels pharmaceutiquement acceptables.

  式 (I) 化合物的工业合成工艺： 其中 R1 代表氢原子或烷基或苄基，R2 代表胺功能的保护基团。 应用于合成 pcrindopril 及其药用盐。