1-(2-acryloyloxy-ethyl)-pyrrolidin-2-one | 3541-31-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(2-acryloyloxy-ethyl)-pyrrolidin-2-one
• 英文别名: 1-(2-Acryloyloxy-aethyl)-pyrrolidin-2-on；N-<2-Acryloyloxy-aethyl>-pyrrolidinon；Pyrrolidonylethyl acrylate；2-(2-oxopyrrolidin-1-yl)ethyl prop-2-enoate
• CAS: 3541-31-9
• 化学式: C₉H₁₃NO₃
• 分子量: 183.207
• InChiKey: GCRIIVPDNWHODP-UHFFFAOYSA-N

物化性质

• 沸点：
  192-194 °C(Press: 2 Torr)
• 密度：
  1.1305 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-羟乙基-2-吡咯烷酮 、 丙烯酸酐 在 吡啶 作用下， 生成 1-(2-acryloyloxy-ethyl)-pyrrolidin-2-one
  参考文献：
  名称：

  N-(acryloxyalkyl)- and n-(methacryloxyalkyl)-2-pyrrolidones and polymers thereof

  摘要：

  公开号：

  US02882262A1

文献信息

• NAPROXEN/DEXAMETHASONE-BASED NANOPARTICLES
  申请人：Consejo Superior de Investigaciones Científicas (CSIC)

  公开号：EP3884963A1

  公开（公告）日：2021-09-29

  The invention relates to novel self-assembled polymeric nanoparticles that comprises covalently-linked non-steroidal anti-inflammatory drugs (NSAIDs) and physically entrapped corticosteroids, and its use to reduce inflammatory responses.

  本发明涉及一种新型自组装聚合物纳米粒子，其包含共价连接的非甾体抗炎药（NSAIDs）和物理上捕获的皮质类固醇，并且用于减少炎症反应。
• Compositions comprising encapsulated material
  申请人：Ness Nicholas Jeremy

  公开号：US20060039934A1

  公开（公告）日：2006-02-23

  A composition such as a water-based consumer product comprises material (e.g. perfume) encapsulated within shell capsules, each capsule comprising an encapsulating wall having an inner surface and an outer surface, with a coating on the inner surface and/or outer surface of the shell wall, the composition further comprising surfactant and/or solvent. The coating can improve the barrier properties of the shell and can enhance retention of the encapsulated materials within the shell.

  一种水基消费品的组合物，包括封装在壳体胶囊内的材料（例如香水），每个胶囊包括具有内表面和外表面的封装壁，壳体壁的内表面和/或外表面上有涂层，组合物进一步包括表面活性剂和/或溶剂。涂层可以改善壳体的屏障性能，并可以增强封装材料在壳体内的保留能力。
• Four component copolymers and the ocular lens made thereof
  申请人：Santen Pharmaceutical Co., Ltd.

  公开号：US06465588B1

  公开（公告）日：2002-10-15

  A hydrophilic copolymer which is suitable for the production of an ocular lens such as an intraocular lens or a contact lens, and which is particularly suitable for a foldable intraocular lens, and also an intraocular lens made therefrom.

  一种适用于生产眼镜片的亲水性共聚物，例如人工晶体或隐形眼镜，特别适用于可折叠的人工晶体，以及由该亲水性共聚物制成的人工晶体。
• ULTRAVIOLET ABSORBING POLYMER, CELLULOSE ESTER OPTICAL FILM, METHOD OF PRODUCING CELLULOSE ESTER OPTICAL FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY
  申请人：Suzuki Takayuki

  公开号：US20100104775A1

  公开（公告）日：2010-04-29

  Disclosed is an ultraviolet absorbing polymer which is characterized by being derived from an ethylenically unsaturated monomer having a partial structure represented by Formula (A) below in a molecule, and a monomer represented by Formula (B) below:

  本发明涉及一种紫外线吸收聚合物，其特征在于其由分子中具有以下式(A)所表示的部分结构的乙烯基不饱和单体和以下式(B)所表示的单体衍生而来：
• TRANSDERMAL ADHESIVE COMPOSITIONS, DEVICES AND METHODS
  申请人：Dizio James P.

  公开号：US20130122079A1

  公开（公告）日：2013-05-16

  A stable transdermal adhesive composition comprising: an adhesive comprising a washed polymerization reaction product of at least two ethylenically unsaturated monomers; and at least one pharmaceutically active compound which is susceptible to oxidative degradation; wherein the at least two ethylenically unsaturated monomers, if present in the adhesive as unreacted monomers, are present at a level of less than 200 ppm of total unreacted monomer, based upon the total weight of the adhesive, methods of making the composition, a transdermal drug delivery device using the composition, methods of making the device, and methods of delivery the pharmaceutically active compound are provided.

  提供一种稳定的经皮粘合剂组合物，包括：一种粘合剂，其包括至少两种乙烯基不饱和单体的洗涤聚合反应产物；以及至少一种易于氧化降解的药物活性化合物；其中，如果至少两种乙烯基不饱和单体以未反应单体的形式存在于粘合剂中，则其存在量不超过总未反应单体的200 ppm，基于粘合剂的总重量；提供制备该组合物的方法，使用该组合物的经皮给药装置，制备该装置的方法，以及给药药物活性化合物的方法。