(Z)-ethyl 3-methylhelpt-2-enoate | 73516-50-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-ethyl 3-methylhelpt-2-enoate
• 英文别名: ethyl 3-methylhepta-2,6-dienoate；ethyl (2Z)-3-methylhepta-2,6-dienoate
• CAS: 73516-50-4
• 化学式: C₁₀H₁₆O₂
• 分子量: 168.236
• InChiKey: OHPWUPYZQFOCEM-HJWRWDBZSA-N

物化性质

• 沸点：
  226.0±19.0 °C(Predicted)
• 密度：
  0.906±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Z)-ethyl 3-methylhelpt-2-enoate 在 lithium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 64.0h， 以92%的产率得到(Z)-3-甲基-2,6-庚二烯酸
  参考文献：
  名称：

  Examination of the olefin–olefin ring closing metathesis to prepare Latrunculin B

  摘要：

  Three subunits of the potent actin polymerization inhibitor Latrunculin B were synthesized and assembled using olefin-olefin ring closing metathesis chemistry to close the 14-membered macrocycle, Metathesis reactions of substrates with various remote protecting group patterns were examined and gave 6,7-E-lactones as the preferred products. (C 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.10.144
• 作为产物：
  描述：

  ethyl hept-6-en-2-ynoate 、 甲基锂 在 copper(l) iodide 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 (Z)-ethyl 3-methylhelpt-2-enoate
  参考文献：
  名称：

  Examination of the olefin–olefin ring closing metathesis to prepare Latrunculin B

  摘要：

  Three subunits of the potent actin polymerization inhibitor Latrunculin B were synthesized and assembled using olefin-olefin ring closing metathesis chemistry to close the 14-membered macrocycle, Metathesis reactions of substrates with various remote protecting group patterns were examined and gave 6,7-E-lactones as the preferred products. (C 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.10.144

文献信息

• Stereoselective Bifurcating-type Radical Cyclization of<i>gem</i>-Dibromocyclopropanes for the Synthesis of Uniquely Fused 5-3-5-Type Tricyclic Compounds
  作者：Yoshinori Nishii、Atsushi Fujiwara、Kazunori Wakasugi、Misao Miki、Kazunori Yanagi、Yoo Tanabe

  DOI：10.1246/cl.2002.30

  日期：2002.1

  Bifurcating radical cyclization of gem-dibromocyclopropane derivatives afforded novel fused 5-3-5 type tricyclic products with high 5-exo-trig and transannular mode.

  gem-二溴环丙烷衍生物的分叉自由基环化提供了具有高5-exo-trig和跨环模式的新型稠合5-3-5型三环产物。
• A newly-designed PE-supported arsine for efficient and practical catalytic Wittig olefination
  作者：Peng Wang、Chun-Rong Liu、Xiu-Li Sun、Shuai-Shuai Chen、Jun-Fang Li、Zuowei Xie、Yong Tang

  DOI：10.1039/c1cc16747b

  日期：——

  A newly designed PE-supported arsine has been developed as an excellent catalyst for catalytic Wittig-type olefination. Simple ketones, in particular inactive ketones prove to be suitable substrates for the first time. This reaction provides an easy access to di-, tri-, and tetra-substituted olefins in high yield.

  新设计的一种PE支持的胂已被开发为优秀的催化Wittig型烯化催化剂。简单的酮类，尤其是不活跃的酮类，首次证明是合适的底物。这一反应提供了一条简便的途径，以高产率获得二、三、四取代烯烃。
• LEE, SUSANNA Y.;NIWA, MAHO;SNIDER, BARRY B., J. ORG. CHEM., 53,(1988) N 10, 2356-2360
  作者：LEE, SUSANNA Y.、NIWA, MAHO、SNIDER, BARRY B.

  DOI：——

  日期：——
• Examination of the olefin–olefin ring closing metathesis to prepare Latrunculin B
  作者：Jin She、John W. Lampe、Alexandra B. Polianski、Paul S. Watson

  DOI：10.1016/j.tetlet.2008.10.144

  日期：2009.1

  Three subunits of the potent actin polymerization inhibitor Latrunculin B were synthesized and assembled using olefin-olefin ring closing metathesis chemistry to close the 14-membered macrocycle, Metathesis reactions of substrates with various remote protecting group patterns were examined and gave 6,7-E-lactones as the preferred products. (C 2008 Elsevier Ltd. All rights reserved.