7-bromo-N-methyl-N-[(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-9H-fluoren-2-amine radical | 1294445-41-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 7-bromo-N-methyl-N-[(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-9H-fluoren-2-amine radical
• 英文别名: HO-4161
• CAS: 1294445-41-2
• 化学式: C₂₃H₂₆BrN₂O
• 分子量: 426.376
• InChiKey: VXEIUVGSSKWOHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  7.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-bromo-N-methyl-N-[(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-9H-fluoren-2-amine radical 在 铁粉 、 溶剂黄146 、 potassium carbonate 作用下， 以 水 为溶剂， 反应 1.0h， 以47%的产率得到7-bromo-N-methyl-N-[(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-9H-fluoren-2-amine
  参考文献：
  名称：

  Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds

  摘要：

  A series of 2-aminofluorenes N-alkylated with nitroxides or their precursors were synthesized. The new compounds were tested on hydroxyl radical and peroxyl radical scavenging ability and inflammatory assay on the endothelial brain cells. In agreement with ROS scavenging ability the same compound 7-bromo-N [(1-Oxyl-2,2.6.6-tetramethyl-1,2,3.6-tetrahydropyridine-4yl)methyl]-9H-fluoren-2-amine (3b) and its hydroxylamine salt (3b/OH/HCl) showed the anti-inflammatory property on the endothelial brain cells. (c) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.01.059
• 作为产物：
  描述：

  2-氨基-7-溴芴 在 sodium cyanoborohydride 、 potassium carbonate 、 溶剂黄146 作用下， 以 二甲基亚砜 为溶剂， 反应 24.17h， 生成 7-bromo-N-methyl-N-[(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-9H-fluoren-2-amine radical
  参考文献：
  名称：

  Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds

  摘要：

  A series of 2-aminofluorenes N-alkylated with nitroxides or their precursors were synthesized. The new compounds were tested on hydroxyl radical and peroxyl radical scavenging ability and inflammatory assay on the endothelial brain cells. In agreement with ROS scavenging ability the same compound 7-bromo-N [(1-Oxyl-2,2.6.6-tetramethyl-1,2,3.6-tetrahydropyridine-4yl)methyl]-9H-fluoren-2-amine (3b) and its hydroxylamine salt (3b/OH/HCl) showed the anti-inflammatory property on the endothelial brain cells. (c) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.01.059

文献信息

• Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds
  作者：Tamás Kálai、Jitka Petrlova、Mária Balog、Hnin Hnin Aung、John C. Voss、Kálmán Hideg

  DOI：10.1016/j.ejmech.2011.01.059

  日期：2011.4

  A series of 2-aminofluorenes N-alkylated with nitroxides or their precursors were synthesized. The new compounds were tested on hydroxyl radical and peroxyl radical scavenging ability and inflammatory assay on the endothelial brain cells. In agreement with ROS scavenging ability the same compound 7-bromo-N [(1-Oxyl-2,2.6.6-tetramethyl-1,2,3.6-tetrahydropyridine-4yl)methyl]-9H-fluoren-2-amine (3b) and its hydroxylamine salt (3b/OH/HCl) showed the anti-inflammatory property on the endothelial brain cells. (c) 2011 Elsevier Masson SAS. All rights reserved.