4-nitro-5-indanol | 139515-85-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 4-nitro-5-indanol
• 英文别名: 5-hydroxy-4-nitroindane；4-nitro-2,3-dihydro-1H-inden-5-ol
• CAS: 139515-85-8
• 化学式: C₉H₉NO₃
• 分子量: 179.175
• InChiKey: LCSMMEHDKHADKM-UHFFFAOYSA-N

物化性质

• 沸点：
  299.0±40.0 °C(Predicted)
• 密度：
  1.391±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 4-nitro-5-indanol 在 乙醚 作用下， 生成 methyl-(4-nitro-indan-5-yl)-ether
  参考文献：
  名称：

  Neunhoeffer, Chemische Berichte, 1935, vol. 68, p. 1774,1778

  摘要：

  DOI：
• 作为产物：
  描述：

  5-氨基茚旦 在 盐酸 、 硝酸 、 sodium nitrite 作用下， 生成 4-nitro-5-indanol
  参考文献：
  名称：

  Neunhoeffer, Chemische Berichte, 1935, vol. 68, p. 1774,1778

  摘要：

  DOI：

文献信息

• Synthesis and Biological Activities of New 2-Substituted 1,4-Benzoxazine Derivatives.
  作者：Masahiro KAJINO、Yumiko SHIBOUTA、Kohei NISHIKAWA、Kanji MEGURO

  DOI：10.1248/cpb.39.2896

  日期：——

  A series of new 1, 4-benzoxazine derivatives (XI, XII) possessing (4-phenyl-1-piperazinyl)alkyl moieties at the 2-position and related compounds (XIII) were synthesized and tested for calcium antagonistic, calmodulin antagonistic and antihypertensive activities. Various compounds had in vitro calmodulin antagonistic activity superior or comparable to that of trifluoperazine. Among these compounds, tetrahydronaphtho[2, 3-b][1, 4]oxazine derivatives such as 51, 53, 54, 58, 59, 60, 73 and 75 showed potent antihypertensive effects in spontaneously hypertensive rats. Optical isomers of 51 were also synthesized and evaluated biologically. No differences in biological activities were seen between the enantiomers.

  一系列新的1,4-苯并恶嗪衍生物（XI，XII）在2位具有（4-苯基-1-哌嗪基）烷基部分及相关化合物（XIII）被合成并测试了钙拮抗、钙调素拮抗和降压活性。多种化合物在体外表现出优于或相当于三氟拉嗪的钙调素拮抗活性。其中，四氢萘并[2,3-b][1,4]恶嗪衍生物如51、53、54、58、59、60、73和75在自发性高血压大鼠中显示出强大的降压效果。51的光学异构体也被合成并进行了生物学评估。这些光学异构体之间在生物活性上没有差异。
• Benzoxazine and benzothiazine derivatives and their use in pharmaceuticals
  申请人：Schering Aktiengesellschaft

  公开号：US06365736B1

  公开（公告）日：2002-04-02

  Described are benzoxazine and benzothiazine compounds of the formula I defined herein, methods for their preparation and methods for their use in pharmaceuticals based on their activity as NO-synthases (NOS) inhibitors.

  本文描述了我在此定义的式I的苯并噁嗪和苯并噻嗪化合物，以及它们的制备方法和基于它们作为一氧化氮合酶（NOS）抑制剂的药物使用方法。
• Carboxamide derivatives
  申请人：Mitsubishi Kasei Corporation

  公开号：US05442060A1

  公开（公告）日：1995-08-15

  Carboxamide derivatives of the following general formula (I): ##STR1## (wherein R.sup.1 and R.sup.2 are C.sub.1 -C.sub.3 alkyl group or both taken together C.sub.1 -C.sub.3 alkylene group, R.sup.3 is hydrogen atom, dialkylamino group, etc., R.sup.4 is hydrogen atom, C.sub.1 -C.sub.10 alkyl group, R.sup.5 is C.sub.1 -C.sub.10 alkyl group, m, n, q are an integer from 0-3, p is 0, 1, A ring is ##STR2## B ring is 5 or 6 membered nitrogen containing aromatic ring, are provided, which are useful as medicinals for treating hyperlipemia or atherosclerosis.

  以下通用公式（I）的羧酰胺衍生物：##STR1##（其中R.sup.1和R.sup.2是C.sub.1 -C.sub.3烷基或两者一起是C.sub.1 -C.sub.3亚基烷基，R.sup.3是氢原子，二烷胺基团，等等，R.sup.4是氢原子，C.sub.1 -C.sub.10烷基，R.sup.5是C.sub.1 -C.sub.10烷基，m、n、q是0-3之间的整数，p是0、1，A环是##STR2## B环是含氮芳环的5或6元环，这些衍生物可用作治疗高脂血症或动脉粥样硬化的药物。
• 2‐Methoxyethyl Nitrite as a Reagent for Chemoselective On‐Water Nitration
  作者：Taku Kitanosono、Airu Hashidoko、Yasuhiro Yamashita、Shū Kobayashi

  DOI：10.1002/asia.202200457

  日期：2022.8.15

  An on-water approach has been developed that allows a chemoselective nitration of tyrosines and phenols. The enticing roles of water in the reaction process introduce new avenues to explore in the design of synthetic organic chemistry systems.

  已经开发了一种允许对酪氨酸和酚进行化学选择性硝化的水上方法。水在反应过程中的诱人作用为合成有机化学系统的设计提供了新的探索途径。
• P2X4 receptor antagonist
  申请人：Sakuma Shogo

  公开号：US08962613B2

  公开（公告）日：2015-02-24

  A diazepine derivative having the following formula (III) or a pharmacologically acceptable salt thereof is used as A P2X4 receptor antagonist: wherein each of R21 and R22 is hydrogen, a C1-8 alkyl group or the like; R23 is hydrogen, a C1-8 alkyl group or the like; each of R24 and R25 is hydrogen, a C1-8 alkyl group or the like; R26 is hydrogen, a C1-8 alkyl group, a halogen atom, hydroxyl, nitro, cyano, phenyl optionally having one or more substituents, or a heterocyclic group optionally having one or more substituents or the like; and p is 0 or 1.

  具有以下式（III）或其药理学上可接受的盐的一种二氮平衍生物作为P2X4受体拮抗剂：其中R21和R22中的每一个是氢，C1-8烷基或类似物；R23是氢，C1-8烷基或类似物；R24和R25中的每一个是氢，C1-8烷基或类似物；R26是氢，C1-8烷基，卤素原子，羟基，硝基，氰基，苯基（可选地具有一个或多个取代基）或含有一个或多个取代基的杂环基或类似物；p为0或1。