1,3-bis(tetrahydrofuran-2-yl)propan-2-one | 1248167-38-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 1,3-bis(tetrahydrofuran-2-yl)propan-2-one
• 英文别名: 1,3-Bis(oxolan-2-yl)propan-2-one
• CAS: 1248167-38-5
• 化学式: C₁₁H₁₈O₃
• 分子量: 198.262
• InChiKey: IBQDETDSPSJRFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-羟基四氢呋喃 、 四乙基(2-氧代-1,3-丙烷二基)二(膦酸酯) 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 110.0 ℃ 、1.72 MPa 条件下， 反应 1.0h， 以56%的产率得到1,3-bis(tetrahydrofuran-2-yl)propan-2-one
  参考文献：
  名称：

  Horner-Wadsworth-Emmons Reactions in THF: Effect of Hydroperoxide Species

  摘要：

  Horner-Wadsworth-Emmons (HWE) reactions routinely employ tetrahydrofuran (THF) as the reaction solvent. In this paper we show that THF adducts (derived from THF-hydroperoxide species) of HWE phosphonate ester compounds are formed under microwave irradiation (i.e., under pressure), or in the presence of a reductant [e.g., P(OEt)(3)] in a conventionally heated reaction.

  DOI：

  10.1055/s-0033-1339200

文献信息

• Horner-Wadsworth-Emmons Reactions in THF: Effect of Hydroperoxide Species
  作者：Ian Fairlamb、Amanda Jarvis、Elizabeth Wells

  DOI：10.1055/s-0033-1339200

  日期：——

  Horner-Wadsworth-Emmons (HWE) reactions routinely employ tetrahydrofuran (THF) as the reaction solvent. In this paper we show that THF adducts (derived from THF-hydroperoxide species) of HWE phosphonate ester compounds are formed under microwave irradiation (i.e., under pressure), or in the presence of a reductant [e.g., P(OEt)(3)] in a conventionally heated reaction.