5-methyl-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine | 72966-19-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-methyl-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine
• 英文别名: 5-methyl-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine；5-methyl-7-phenyl-1,2,4-triazolo[1,5-a]pyrimidin-2-amine；5-Methyl-7-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-2-amine
• CAS: 72966-19-9
• 化学式: C₁₂H₁₁N₅
• mdl: MFCD03856667
• 分子量: 225.253
• InChiKey: ZCOHGHCESYZASH-UHFFFAOYSA-N

物化性质

• 溶解度：
  23 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  69.1
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  5-methyl-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine 在 sodium nitrite 作用下， 以 盐酸 、 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 生成 2-Chloro-5-methyl-7-phenyl-1,2,4-triazolo[1,5-a]pyrimidine
  参考文献：
  名称：

  Substituted phenyltriazolopyrimidine herbicides

  摘要：

  新型取代苯基三唑吡啶类化合物及其制备方法和作为草甭前除草剂和后除草剂的使用方法。

  公开号：

  US05127936A1
• 作为产物：
  描述：

  2-amino-5-methyl-7-phenyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine 在 盐酸 、 溴 、 sodium acetate 、 溶剂黄146 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.3h， 生成 5-methyl-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine
  参考文献：
  名称：

  Improved synthesis of 2-amino-1,2,4-triazolo[1,5-a]pyrimidines

  摘要：

  An improved procedure is suggested for preparing 2-amino-1,2,4-triazolo[1,5-a]pyrimidines from 3,5-diamino-1,2,4-triazole and unsaturated aromatic ketones, with acetyl protection of the amino group in the step of oxidation of 2-amino-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidines.

  DOI：

  10.1134/s1070427206070172

文献信息

• Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives
  作者：Serena Massari、Jenny Desantis、Giulio Nannetti、Stefano Sabatini、Sara Tortorella、Laura Goracci、Violetta Cecchetti、Arianna Loregian、Oriana Tabarrini

  DOI：10.1039/c7ob02085f

  日期：——

  facile and efficient one-step procedures for the regioselective synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidines have been developed, via reactions of 3,5-diamino-1,2,4-triazole with variously substituted 1-aryl-1,3-butanediones and 1-aryl-2-buten-1-ones, respectively. The excellent yield and/or regioselectivity shown by the reactions decreased when ethyl 5-amino-1

  区域选择性合成7-芳基-5-甲基-和5-芳基-7-甲基-2-氨基-[1,2,4]三唑并[1,5-a]嘧啶的两种简便有效的一步步骤通过3，5-二氨基-1，2，4-三唑分别与各种取代的1-芳基-1，3-丁二酮和1-芳基-2-丁烯-1-酮的反应，已经开发出。当使用5-氨基-1，2，4-三唑-3-羧酸乙酯时，反应显示的优异的产率和/或区域选择性降低。作为[1,2,4]三唑并[1,5-a]嘧啶的特有支架，本文报道的方法可用于制备生物活性化合物。在这项研究中，基于[1,2,4] triazolo [1，
• Methods of treating muscular dystrophy
  申请人：Burkin Dean

  公开号：US10028992B2

  公开（公告）日：2018-07-24

  Disclosed herein are α7β1 integrin modulatory agents and methods of using such to treat conditions associated with decreased α7β1 integrin expression or activity, including muscular dystrophy. In one example, methods for treating a subject with muscular dystrophy are disclosed. The methods include administering an effective amount of an α7β1 integrin modulatory agent to the subject with muscular dystrophy, wherein the α7β1 integrin modulatory agent increases α7β1 integrin expression or activity as compared to α7β1 integrin expression or activity prior to treatment, thereby treating the subject with muscular dystrophy. Also disclosed are methods of enhancing muscle regeneration, repair, or maintenance in a subject and methods of enhancing α7β1 integrin expression by use of the disclosed α7β1 integrin modulatory agents. Methods of prospectively preventing or reducing muscle injury or damage in a subject are also disclosed.

  本文公开了α7β1整合素调节剂以及用其治疗与α7β1整合素表达或活性降低有关的疾病（包括肌肉萎缩症）的方法。在一个例子中，公开了治疗肌肉萎缩症患者的方法。该方法包括向肌肉萎缩症患者施用有效量的α7β1整合素调节剂，其中与治疗前的α7β1整合素表达或活性相比，α7β1整合素调节剂可增加α7β1整合素表达或活性，从而治疗肌肉萎缩症患者。还公开了增强受试者肌肉再生、修复或维持的方法，以及通过使用公开的α7β1整合素调节剂增强α7β1整合素表达的方法。还公开了预防或减少受试者肌肉损伤或损害的方法。
• A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits
  作者：Serena Massari、Giulio Nannetti、Jenny Desantis、Giulia Muratore、Stefano Sabatini、Giuseppe Manfroni、Beatrice Mercorelli、Violetta Cecchetti、Giorgio Palù、Gabriele Cruciani、Arianna Loregian、Laura Goracci、Oriana Tabarrini

  DOI：10.1021/acs.jmedchem.5b00012

  日期：2015.5.14

  In continuing our efforts to identify Small molecules able; to disrupt the interaction of the polymerase acidic protein-basic protein 1 (PA-PB1) subunits of Influenza Virus (Flu) RNA-dependent RNA polymerase, this paper is devoted to the optimization of a dihydrotriazolopyrimidine derivative, previously identified throught structure-based drug discovery. The structure modifications performed around the bicyclic core led to the identification of compounds endowed with both the ability to disrupt PA-PB1 subunits interaction and anti-Flu activity with no cytotoxicity. Very interesting results were obtained with the hybrid molecules 36 and 37, designed by merging some peculiar structural features known to impart PA-PB1 interaction inhibition, with compound 36 that emerged as the most potent PA-PB1 interaction inhibitor (IC50 = 1.1 mu M) among all the small molecules reported so far. Calculations Showed a very favoted H-bonding between the 2-amidic carbonyl of 36 and Q408, which seems to justify its potent ability to interfere with the interaction of the polymerase subunits.
• KREUTZBERGER A.; RISSE G., ARCH. PHARM., 1979, 312, NO 12, 1003-1006
  作者：KREUTZBERGER A.、 RISSE G.

  DOI：——

  日期：——
• METHODS OF TREATING MUSCULAR DYSTROPHY
  申请人：Board of Regents of the Nevada System of Higher Education, on Behalf of the University of Nevada, Reno

  公开号：EP2892525B1

  公开（公告）日：2018-06-13