3-(1-(4-chlorophenyl)-2-nitroethyl)-6-fluoro-1H-indole | 1586813-09-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(1-(4-chlorophenyl)-2-nitroethyl)-6-fluoro-1H-indole
• 英文别名: 3-[1-(4-chlorophenyl)-2-nitroethyl]-6-fluoro-1H-indole
• CAS: 1586813-09-3
• 化学式: C₁₆H₁₂ClFN₂O₂
• 分子量: 318.735
• InChiKey: LUVHMCUSQBHWFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-氟吲哚 、 1-nitro-2-(4-chlorophenyl)ethylene 在 HY zeolite 作用下， 以 neat (no solvent) 为溶剂， 反应 1.5h， 以85%的产率得到3-(1-(4-chlorophenyl)-2-nitroethyl)-6-fluoro-1H-indole
  参考文献：
  名称：

  Michael addition of indoles to β-nitrostyrenes catalyzed by HY zeolite under solvent-free conditions

  摘要：

  Michael addition of indoles to beta-nitrostyrenes is reported using HY zeolite as catalyst under mild reaction conditions. This methodology allows the synthesis of various indole derivatives in good to high yields at 50 C under solvent-free conditions. The short reaction time and achieving high yield of the desired products are the main advantages of the present work. The catalyst can be easily recovered and reused for six successive runs without considerable changes in yields. This Michael addition catalyzed by HY zeolite is operationally simple and can be considered as a greener protocol as it avoids the use of corrosive acids and toxic reagents. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.112

文献信息

• Michael addition of indoles to β-nitrostyrenes catalyzed by HY zeolite under solvent-free conditions
  作者：Mariappan Jeganathan、Kuppusamy Kanagaraj、Amarajothi Dhakshinamoorthy、Kasi Pitchumani

  DOI：10.1016/j.tetlet.2014.01.112

  日期：2014.3

  Michael addition of indoles to beta-nitrostyrenes is reported using HY zeolite as catalyst under mild reaction conditions. This methodology allows the synthesis of various indole derivatives in good to high yields at 50 C under solvent-free conditions. The short reaction time and achieving high yield of the desired products are the main advantages of the present work. The catalyst can be easily recovered and reused for six successive runs without considerable changes in yields. This Michael addition catalyzed by HY zeolite is operationally simple and can be considered as a greener protocol as it avoids the use of corrosive acids and toxic reagents. (C) 2014 Elsevier Ltd. All rights reserved.