4,6-diethoxy-m-phenylenediamine | 68034-19-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4,6-diethoxy-m-phenylenediamine
• 英文别名: 4,6-Diaethoxy-m-phenylendiamin；4.6-Diamino-resorcin-diaethylaether；4,6-Diethoxybenzene-1,3-diamine；4,6-diethoxybenzene-1,3-diamine
• CAS: 68034-19-5
• 化学式: C₁₀H₁₆N₂O₂
• 分子量: 196.249
• InChiKey: SRZHLAPNQNMXIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  70.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  氯甲酸-9-芴基甲酯 、 4,6-diethoxy-m-phenylenediamine 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以70%的产率得到(5-Amino-2,4-diethoxy-phenyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
  参考文献：
  名称：

  Hydrogen-Bonding-Mediated Anthranilamide Homoduplexes. Increasing Stability through Preorganization and Iterative Arrangement of a Simple Amide Binding Site

  摘要：

  This paper describes the assembly of two new series of self-complementary duplexes by making use of amide units, the simplest assembling units of hydrogen bonding, as binding sites. All the new monomers possess a rigidified anthranilamide skeleton, which is stabilized by intramolecular hydrogen bonding. Amide units are iteratively introduced to one side of the preorganized skeletons to facilitate the formation of intermolecular hydrogen bonding. Compounds 2 and 3 bear two and three CONH2 units, respectively, while 4, 6, and 7 are incorporated with two, three, and four AcNH units, respectively. For comparison, compound 5, which is similar to 4 but contains one AcNH and one CF3CONH unit, is also prepared. X-ray diffraction analysis of 2, 4, and 5 revealed homodimeric motifs in the solid state which are stabilized by two or more intermolecular hydrogen bonds. H-1 NMR investigations in CDCl3 indicated that all the compounds form hydrogen-bonded homoduplexes. Duplexes 3(.)3, 6(.)6, and 7(.)7 are highly stable in CDCl3, with a lower K-assoc limit of 2.3 x 10(5) M-1. The K-assoc values of the three duplexes in more polar CDCl3/CD3CN (9:1, v/v) were determined with the H-1 NMR dilution method. The result opens the way for the development of new polymeric duplexes of well-ordered structures.

  DOI：

  10.1021/ja064218i
• 作为产物：
  描述：

  5-chloro-2,4-dinitro-phenetole 在 盐酸 、 tin 作用下， 生成 4,6-diethoxy-m-phenylenediamine
  参考文献：
  名称：

  Lorang, Recueil des Travaux Chimiques des Pays-Bas, 1928, vol. 47, p. 188

  摘要：

  DOI：

文献信息

• Hydrogen-Bonding-Mediated Dynamic Covalent Synthesis of Macrocycles and Capsules: New Receptors for Aliphatic Ammonium Ions and the Formation of Pseudo[3]rotaxanes
  作者：Xiao-Na Xu、Lu Wang、Gui-Tao Wang、Jian-Bin Lin、Guang-Yu Li、Xi-Kui Jiang、Zhan-Ting Li

  DOI：10.1002/chem.200900309

  日期：2009.6.2

  Dynamic covalent synthesis! Intramolecular hydrogen‐bonding induces amino‐ and aldehyde‐appended aryl amides to adopt a rigid “V”‐shaped conformation. As a result, stable two‐layered capsules can be assembled quantitatively through the one‐step formation of six imine bonds. The new capsules form complexes with aliphatic diammonium ions to give unique two‐layered pseudo[3]rotaxanes (see figure).

  动态共价合成！分子内氢键诱导氨基和醛基连接的芳基酰胺采用刚性的“ V”形构象。结果，可以通过一步形成六个亚胺键来定量组装稳定的两层胶囊。新的胶囊与脂肪族二铵离子形成复合物，从而形成独特的两层假[3]轮烷（见图）。
• Hydrogen bonding-mediated self-assembly of anthranilamide-based homodimers through preorganization of the amido and ureido binding sites
  作者：Jiang Zhu、Jian-Bin Lin、Yun-Xiang Xu、Xi-Kui Jiang、Zhan-Ting Li

  DOI：10.1016/j.tet.2006.09.073

  日期：2006.12

  Tbe self-assembly of a novel series of hydrogen bonding-mediated homodimers in chloroform-d has been described. Six anthranilamide-based monomers have been prepared, in which two self-binding formamido, trifluoroacetamido, acetamido, butyl or methyl ureido units are introduced at the two ends of the backbones. Quantitative H-1 NMR investigations in chloroform-d revealed that the formamido and ureido units are more efficient than acetamido to induce the formation of stable homodimers. The association constants of all the new homodimers have been determined by H-1 NMR dilution method. Multiply hydrogen bonding-driven binding patterns have been proposed for the homodimers. It is also found that ureido-derived homodimers do not adopt common linear binding pattern observed for simple urea derivatives. (c) 2006 Elsevier Ltd. All rights reserved.
• Hydrogen-Bonding-Mediated Anthranilamide Homoduplexes. Increasing Stability through Preorganization and Iterative Arrangement of a Simple Amide Binding Site
  作者：Jiang Zhu、Jian-Bin Lin、Yun-Xiang Xu、Xue-Bin Shao、Xi-Kui Jiang、Zhan-Ting Li

  DOI：10.1021/ja064218i

  日期：2006.9.1

  This paper describes the assembly of two new series of self-complementary duplexes by making use of amide units, the simplest assembling units of hydrogen bonding, as binding sites. All the new monomers possess a rigidified anthranilamide skeleton, which is stabilized by intramolecular hydrogen bonding. Amide units are iteratively introduced to one side of the preorganized skeletons to facilitate the formation of intermolecular hydrogen bonding. Compounds 2 and 3 bear two and three CONH2 units, respectively, while 4, 6, and 7 are incorporated with two, three, and four AcNH units, respectively. For comparison, compound 5, which is similar to 4 but contains one AcNH and one CF3CONH unit, is also prepared. X-ray diffraction analysis of 2, 4, and 5 revealed homodimeric motifs in the solid state which are stabilized by two or more intermolecular hydrogen bonds. H-1 NMR investigations in CDCl3 indicated that all the compounds form hydrogen-bonded homoduplexes. Duplexes 3(.)3, 6(.)6, and 7(.)7 are highly stable in CDCl3, with a lower K-assoc limit of 2.3 x 10(5) M-1. The K-assoc values of the three duplexes in more polar CDCl3/CD3CN (9:1, v/v) were determined with the H-1 NMR dilution method. The result opens the way for the development of new polymeric duplexes of well-ordered structures.
• Lorang, Recueil des Travaux Chimiques des Pays-Bas, 1928, vol. 47, p. 188
  作者：Lorang

  DOI：——

  日期：——