3-Oxotetradecanoyl-CoA | 122364-86-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Oxotetradecanoyl-CoA
• 英文别名: S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-oxotetradecanethioate
• CAS: 122364-86-7
• 化学式: C₃₅H₆₀N₇O₁₈P₃S
• 分子量: 991.9
• InChiKey: IQNFBGHLIVBNOU-QSGBVPJFSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  64
• 可旋转键数：
  32
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  406
• 氢给体数：
  9
• 氢受体数：
  23

文献信息

• MICROORGANISMS AND METHODS FOR PRODUCING BUTADIENE AND RELATED COMPOUNDS BY FORMATE ASSIMILATION
  申请人：Genomatica, Inc.

  公开号：US20150050708A1

  公开（公告）日：2015-02-19

  Provided herein are non-naturally occurring microbial organisms having a formaldehyde fixation pathway and a formate assimilation pathway, which can further include a methanol metabolic pathway, a methanol oxidation pathway, a hydrogenase and/or a carbon monoxide dehydrogenase. These microbial organisms can further include a butadiene, 1,3-butanediol, crotyl alcohol or 3-buten-2-ol pathway. Additionally provided are methods of using such microbial organisms to produce butadiene, 1,3-butanediol, crotyl alcohol or 3-buten-2-ol.

  本文提供了一些非自然产生的微生物有甲醛固定途径和甲酸同化途径，这些微生物还可以包括甲醇代谢途径、甲醇氧化途径、氢化酶和/或一氧化碳脱氢酶。这些微生物还可以包括丁二烯、1,3-丁二醇、巴豆醇或3-丁烯-2-醇途径。此外，还提供了使用这些微生物生产丁二烯、1,3-丁二醇、巴豆醇或3-丁烯-2-醇的方法。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Microorganisms and methods for production of specific length fatty alcohols and related compounds
  申请人：Genomatica, Inc.

  公开号：US11186853B2

  公开（公告）日：2021-11-30

  The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length. Also provided are non-naturally occurring microbial organisms having a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms further include an acetyl-CoA pathway. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde or a fatty acid.

  本发明提供了一种非天然存在的微生物有机体，其含有脂肪醇、脂肪醛或脂肪酸的生产途径，并且这些微生物有机体可以选择性地生成指定长度的脂肪醇、脂肪醛或脂肪酸。此外，本发明还提供了另外一种非天然存在的微生物有机体，其同样拥有脂肪醇、脂肪醛或脂肪酸的生产途径，同时这些微生物有机体包括乙酰辅酶A（acetyl-CoA）的生产途径。在某些情况下，本发明的微生物有机体具有特定基因的中断或酶活性的减弱，这种特征能够促进脂肪醇、脂肪醛或脂肪酸的生成。另外，本发明还提供了一种使用上述微生物有机体来合成脂肪醇、脂肪醛或脂肪酸的方法。
• MICROORGANISM PRODUCTION OF HIGH-VALVE CHEMICAL PRODUCTS, AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
  申请人：OPX Biotechnologies Inc.

  公开号：EP2529023A1

  公开（公告）日：2012-12-05
• MICROORGANISMS AND METHODS FOR PRODUCTION OF SPECIFIC LENGTH FATTY ALCOHOLS AND RELATED COMPOUNDS
  申请人：Genomatica, Inc.

  公开号：EP2906705A1

  公开（公告）日：2015-08-19