3-(4-(2-(4-羟基苯基)丙烷-2-基)苯氧基)丙烷-1,2-二醇 | 13634-08-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(4-(2-(4-羟基苯基)丙烷-2-基)苯氧基)丙烷-1,2-二醇
• 英文名称: 4-Hydroxy Bisphenol A (2,3-Dihydroxypropyl) Ether
• 英文别名: 3-[4-[2-(4-hydroxyphenyl)propan-2-yl]phenoxy]propane-1,2-diol
• CAS: 13634-08-7
• 化学式: C₁₈H₂₂O₄
• 分子量: 302.37
• InChiKey: PUZZIXGIFLTKTJ-UHFFFAOYSA-N

物化性质

• 沸点：
  516.8±50.0 °C(Predicted)
• 密度：
  1.192±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(4-(2-(4-羟基苯基)丙烷-2-基)苯氧基)丙烷-1,2-二醇 、 丙二酚四异丙醇醚 在 丙二醇甲醚醋酸酯 盐酸 作用下， 以 丙二醇甲醚 为溶剂， 反应 5.5h， 生成 3-[4-[2-[4-[2-(Chloromethyl)-3-(oxiran-2-ylmethoxy)propoxy]phenyl]propan-2-yl]phenoxy]propane-1,2-diol 、 4-[2-[4-(3-Chloro-2-hydroxypropoxy)phenyl]propan-2-yl]phenol 、 3-[4-[1-[4-(3-氯-2-羟基丙氧基)苯基]-1-甲基乙基]苯氧基]-1,2-丙二醇 、 [1-Chloro-3-[4-[2-[4-(3-chloro-2-hydroxypropoxy)phenyl]propan-2-yl]phenoxy]propan-2-yl] acetate 、 5-[4-[2-[4-(2,3-Dihydroxypropoxy)phenyl]propan-2-yl]phenoxy]-4-hydroxypentan-2-one 、 [3-[4-[2-[4-(3-Chloro-2-hydroxypropoxy)phenyl]propan-2-yl]phenoxy]-2-hydroxypropyl] acetate 、 1-Chloro-3-[3-chloro-2-[[4-[2-[4-(3-chloro-2-hydroxypropoxy)phenyl]propan-2-yl]phenoxy]methyl]propoxy]propan-2-ol 、 双酚 A 二(3-氯-2-羟丙基)醚
  参考文献：
  名称：

  Process for manufacturing an alpha-dihydroxy derivative and epoxy resins prepared therefrom

  摘要：

  从芳基烯丙基醚制备α-二羟基衍生物的制造过程，其中该α-二羟基衍生物可用于制备α-卤代醇中间体和由此制备的环氧树脂，包括在氧化剂存在下或在氧化剂和催化剂存在下通过卤代物取代从α-二羟基衍生物脱氢反应中获得的α-卤代醇中间体的环氧化。

  公开号：

  US06646102B2
• 作为产物：
  描述：

  4-(2-(4-(allyloxy)phenyl)propane-2-yl)phenol 、 双酚A双烯丙基醚 在 potassium osmate(VI) 、 水 、 N-甲基吗啉氧化物 作用下， 以 叔丁醇 为溶剂， 反应 43.0h， 以97.2%的产率得到丙二酚四异丙醇醚
  参考文献：
  名称：

  Process for manufacturing an alpha-dihydroxy derivative and epoxy resins prepared therefrom

  摘要：

  从芳基烯丙基醚制备α-二羟基衍生物的制造过程，其中该α-二羟基衍生物可用于制备α-卤代醇中间体和由此制备的环氧树脂，包括在氧化剂存在下或在氧化剂和催化剂存在下通过卤代物取代从α-二羟基衍生物脱氢反应中获得的α-卤代醇中间体的环氧化。

  公开号：

  US06646102B2

文献信息

• ESTER DERIVATIVES OF ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE
  申请人：The University of British Columbia

  公开号：US20140335080A1

  公开（公告）日：2014-11-13

  Compounds having a structure of Structure I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , J 1 , J 2 , X, Z, n 1 and n 2 are as defined herein, and wherein at least one of R 1 , R 2 or R 3 is an alkyl, alkenyl, aryl or aralkyl ester, are provided. Uses of such compounds for treatment of various indications, including prostate cancer, as well as methods of treatment involving such compounds are also provided.

  具有结构I的化合物：或其药学上可接受的盐、互变异构体或立体异构体，其中R1、R2、R3、R4、R5、J1、J2、X、Z、n1和n2如本文所定义，并且其中至少有一个R1、R2或R3是烷基、烯基、芳基或芳基酯。提供了这些化合物用于治疗各种适应症，包括前列腺癌的用途，以及涉及这些化合物的治疗方法。
• Cellulose Compound Film, Optical Compensation Sheet, Polarizing Plate, and Liquid Crystal Display Device
  申请人：Nozoe Yutaka

  公开号：US20070259134A1

  公开（公告）日：2007-11-08

  A cellulose compound film containing a cellulose compound having two or more substituents whose polarizability anisotropies Δα calculated by mathematical formula (1) are different from each other, wherein substitution degrees of the following substituents A and B in the cellulose compound satisfy relationship as defined by mathematical formula (A1), in which the substituent A has the lowest Δα and the substituent B has the highest Δα: Δ ⁢ ⁢ α = α ⁢ ⁢ x - α ⁢ ⁢ y + α ⁢ ⁢ z 2 Mathematical ⁢ ⁢ formula ⁢ ⁢ ( 1 ) wherein, in characteristic values obtained after diagonalization of polarizability tensor, αx is the largest component, αy is the second largest component, and αz is the smallest component; DS B 2+ DS B 3− DS B 6≧−0.1   Mathematical formula (A1) wherein DS B 2, DS B 3, and DS B 6 represent a substitution degree of the substituent B at the 2-, 3-, or 6-position of a β-glucose ring constituting unit of cellulose, respectively; and an optical compensation film, a polarizing plate, and a liquid crystal display device, using the cellulose compound film.

  一种纤维素化合物薄膜，其含有具有两个或更多取代基的纤维素化合物，其极化率各向异性Δα通过数学公式（1）计算得出，其中以下取代基A和B的取代度满足数学公式（A1）所定义的关系，其中取代基A具有最低的Δα，而取代基B具有最高的Δα：Δα = αx-αy + αz2数学公式（1）其中，在极化率张量对角化后获得的特征值中，αx是最大分量，αy是第二大分量，αz是最小分量;DSB2 + DSB3-DSB6≥-0.1数学公式（A1）其中DSB2、DSB3和DSB6分别表示取代基B在纤维素构成单位β-葡萄糖环的2-、3-或6-位置的取代度;以及使用该纤维素化合物薄膜的光学补偿膜、偏光板和液晶显示装置。
• Cellulose Acylate Film, Method of Producing the Same, Cellulose Derivative Film, Optically Compensatory Film Using the Same, Optically-Compensatory Film Incorporating Polarizing Plate, Polarizing Plate and Liquid Crystal Display Device
  申请人：Haruta Hiromoto

  公开号：US20090290100A1

  公开（公告）日：2009-11-26

  A method of producing a cellulose derivative film, the method comprising: forming a film with a solvent cast method from a dope including a cellulose derivative satisfying following conditions (a) and (b): (a) at least one among three hydroxyl groups included in a glucose unit of cellulose is substituted by a substituent of which a polarizability anisotropy Δα represented as following Expression (1) is 2.5×10 −24 cm 3 or higher: Expression (1): Δα=αx−(αy+αz)/2, wherein αx, αy and αz is as defined in the specification; and (b) when a substitution degree by a substituent of which Δα is 2.5×10 −24 cm 3 or higher is P A , and a substitution degree by a substituent of which Δα is lower than 2.5×10 −24 cm 3 is P B , the P A and P B satisfy following Expressions (3) and (4): Expression (3): 2P A +P B >3.0; and Expression (4): P A >0.2.

  一种生产纤维素衍生物薄膜的方法，该方法包括：使用包括满足以下条件（a）和（b）的纤维素衍生物的溶胶，通过溶剂浇铸法形成薄膜：（a）纤维素的葡萄糖单元中的三个羟基中的至少一个被取代为极化率各向异性Δα（以下表达式（1）表示）为2.5×10-24cm3或更高的取代基：表达式（1）：Δα=αx-（αy+αz）/ 2，其中αx，αy和αz如规范中定义的；并且（b）当Δα为2.5×10-24cm3或更高的取代基的取代度为PA时，Δα低于2.5×10-24cm3的取代基的取代度为PB，PA和PB满足以下表达式（3）和（4）：表达式（3）：2PA + PB> 3.0；表达式（4）：PA> 0.2。
• Method and apparatus for continuous hardening of visible light-curing resins
  申请人：JAPAN INSTITUTE OF ADVANCED DENTISTRY

  公开号：EP0420369A2

  公开（公告）日：1991-04-03

  A method and an apparatus for continuously hardening visible-light-curing resins are disclaimed. An object (10), such as an orthodontic bracket, made of visible-light-curing resins, is carried on a conveyor (2) past a row of halogen lamps (1), and sensors (6) detect the temperature in zones of the row whereby controllers (7) activate cooling fans (5) to maintain the temperature in each zone. The objects are moved continuously, either in a non-stop or intermittent manner, and deep uniform hardening is achieved.

  本发明公开了一种连续硬化可见光固化树脂的方法和设备。 由可见光固化树脂制成的物体（10），如牙齿矫正托架，在传送带（2）上经过一排卤素灯（1），传感器（6）检测该排区域的温度，控制器（7）启动冷却风扇（5）以保持每个区域的温度。物体以不停或间歇的方式连续移动，实现深度均匀硬化。
• Thermoplastic saturated norbornene group polymer composition
  申请人：NIPPON ZEON CO., LTD.

  公开号：EP0498564A2

  公开（公告）日：1992-08-12

  Provided is a resin composition based on a thermoplastic saturated norbornene group polymer which is excellent in adhesion to the recording film of optical disks and adhesion to a hard coating film or a protective film formed by coating an acrylic ultraviolet curing coating material or like films without deteriorating excellent heat resistance and transparency inherent to thermoplastic saturated norbornene group polymers. Also provided are optical disk substrates and optical disks by using said composition. A composition comprising a thermoplastic saturated norbornene group polymer and a partially etherified product of a polyhydric alcohol having 3 or more hydroxyl groups incorporated thereinto. An optical disk substrate formed of said composition and an optical disk comprising said optical disk substrate and an information recording film and/or a light reflecting film and a protective film laminated thereon.

  本发明提供了一种基于热塑性饱和降冰片烯基聚合物的树脂组合物，该组合物与光盘记录膜的粘合性以及与硬涂膜或通过涂覆丙烯酸紫外线固化涂层材料或类似薄膜而形成的保护膜的粘合性极佳，且不会降低热塑性饱和降冰片烯基聚合物固有的优异耐热性和透明度。此外，还提供了使用所述组合物的光盘基板和光盘。 一种组合物，由热塑性饱和降冰片烯基聚合物和含有 3 个或 3 个以上羟基的多元醇的部分醚化产物组成。由所述组合物形成的光盘基板，以及由所述光盘基板和信息记录膜和/或光反射膜以及层压在其上的保护膜组成的光盘。