morpholine-4-carboxylic acid (5-nitro-furan-2-ylmethylene)-hydrazide | 15970-86-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: morpholine-4-carboxylic acid (5-nitro-furan-2-ylmethylene)-hydrazide
• 英文别名: N-[(5-nitrofuran-2-yl)methylideneamino]morpholine-4-carboxamide
• CAS: 15970-86-2
• 化学式: C₁₀H₁₂N₄O₅
• 分子量: 268.229
• InChiKey: NVAUCWNDTOEUTI-UHFFFAOYSA-N

物化性质

• 密度：
  1.55±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 海关编码：
  2934999090

反应信息

• 作为产物：
  描述：

  N-苯氧羰基吗啉 在 硫酸 、 水 、 一水合肼 作用下， 反应 14.0h， 生成 morpholine-4-carboxylic acid (5-nitro-furan-2-ylmethylene)-hydrazide
  参考文献：
  名称：

  Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives

  摘要：

  Several novel semicarbazones derivatives were prepared from 5-nitro-2-furaldehyde or 5-nitrothiophene-2-carboxaldehyde, and tested in vitro as potential anti trypanosomal agents. The compounds were prepared in good to excellent yields in 2-3 steps from readily available starting materials. Some derivatives were found to be active against Trypanosoma cruzi with an activity similar to that of Nifurtimox. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(97)00011-6

文献信息

• Antibacterial Nitrofuran Derivatives. I. 5-Nitro-2-furaldehyde Semicarbazones and Thiosemicarbazones
  作者：D. Nardi、E. Massarani、A. Tajana、L. Degen、M. J. Magistretti

  DOI：10.1021/jm00316a006

  日期：1967.7
• Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives
  作者：Hugo Cerecetto、Rossanna Di Maio、Gerardo Ibarruri、Gustavo Seoane、Ana Denicola、Gonzalo Peluffo、Celia Quijano、Margot Paulino

  DOI：10.1016/s0014-827x(97)00011-6

  日期：1998.2

  Several novel semicarbazones derivatives were prepared from 5-nitro-2-furaldehyde or 5-nitrothiophene-2-carboxaldehyde, and tested in vitro as potential anti trypanosomal agents. The compounds were prepared in good to excellent yields in 2-3 steps from readily available starting materials. Some derivatives were found to be active against Trypanosoma cruzi with an activity similar to that of Nifurtimox. (C) 1998 Elsevier Science S.A. All rights reserved.