1,1'-dimethylsulfonyl-5,6,7,8,9,10,5',6',7',8',9',10'-dodecahydro-3,3'-bicycloocta[c]pyridine | 870681-42-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,1'-dimethylsulfonyl-5,6,7,8,9,10,5',6',7',8',9',10'-dodecahydro-3,3'-bicycloocta[c]pyridine
• 英文别名: 1-Methylsulfonyl-3-(1-methylsulfonyl-5,6,7,8,9,10-hexahydrocycloocta[c]pyridin-3-yl)-5,6,7,8,9,10-hexahydrocycloocta[c]pyridine；1-methylsulfonyl-3-(1-methylsulfonyl-5,6,7,8,9,10-hexahydrocycloocta[c]pyridin-3-yl)-5,6,7,8,9,10-hexahydrocycloocta[c]pyridine
• CAS: 870681-42-8
• 化学式: C₂₄H₃₂N₂O₄S₂
• 分子量: 476.661
• InChiKey: DHOUCBXIRQUMTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,1'-dimethylsulfonyl-5,6,7,8,9,10,5',6',7',8',9',10'-dodecahydro-3,3'-bicycloocta[c]pyridine 在 Grubbs catalyst first generation 、 sodium hydride 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Ring-closing metathesis approach to symmetrical and unsymmetrical cycloakeno[c]fused 2,2′-bipyridine-based cyclophanes

  摘要：

  Ring-closing metathesis reactions of symmetrical and unsymmetrical cycloalkeno[c]fused 2,2'-bipyridines, substituted at the alpha and alpha' positions of the pyridine rings with sufficiently long alkenyl ethers, afforded 16-membered cyclophanes, possessing variously annulated 2,2'-bipyridine subunits. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.08.081
• 作为产物：
  描述：

  1,1'-Bis-methylsulfanyl-5,6,7,8,9,10,5',6',7',8',9',10'-dodecahydro-[3,3']bi[cycloocta[c]pyridinyl] 在 potassium permanganate 、 四丁基溴化铵 、 溶剂黄146 作用下， 以 水 、 苯 为溶剂， 反应 3.0h， 以87%的产率得到1,1'-dimethylsulfonyl-5,6,7,8,9,10,5',6',7',8',9',10'-dodecahydro-3,3'-bicycloocta[c]pyridine
  参考文献：
  名称：

  Ring-closing metathesis approach to symmetrical and unsymmetrical cycloakeno[c]fused 2,2′-bipyridine-based cyclophanes

  摘要：

  Ring-closing metathesis reactions of symmetrical and unsymmetrical cycloalkeno[c]fused 2,2'-bipyridines, substituted at the alpha and alpha' positions of the pyridine rings with sufficiently long alkenyl ethers, afforded 16-membered cyclophanes, possessing variously annulated 2,2'-bipyridine subunits. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.08.081

文献信息

• Ring-closing metathesis approach to symmetrical and unsymmetrical cycloakeno[c]fused 2,2′-bipyridine-based cyclophanes
  作者：D. Branowska、A. Rykowski

  DOI：10.1016/j.tet.2005.08.081

  日期：2005.11

  Ring-closing metathesis reactions of symmetrical and unsymmetrical cycloalkeno[c]fused 2,2'-bipyridines, substituted at the alpha and alpha' positions of the pyridine rings with sufficiently long alkenyl ethers, afforded 16-membered cyclophanes, possessing variously annulated 2,2'-bipyridine subunits. (c) 2005 Elsevier Ltd. All rights reserved.