2-methoxy-4-propylbenzaldehyde | 891859-10-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxy-4-propylbenzaldehyde
• 英文别名: 2-Methoxy-4-propylbenzaldehyde
• CAS: 891859-10-2
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: ODAAJSMRWJOIIA-UHFFFAOYSA-N

物化性质

• 沸点：
  291.9±20.0 °C(Predicted)
• 密度：
  1.021±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methoxy-4-propylbenzaldehyde 在 sodium tetrahydroborate 、 水 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 (2-methoxy-4-propylphenyl)methanol
  参考文献：
  名称：

  WO2006/64757

  摘要：

  公开号：
• 作为产物：
  描述：

  3-正-丙基苯酚 在 potassium carbonate 、 三乙胺 、 magnesium chloride 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 2.5h， 生成 2-methoxy-4-propylbenzaldehyde
  参考文献：
  名称：

  [EN] AMIDE PRODRUGS AND USES THEREOF
  [FR] PROMÉDICAMENTS D'AMIDE ET LEURS UTILISATIONS

  摘要：

  Described herein are amide prodrugs, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in treating a CNS disease or disorder.

  公开号：

  WO2024036112A1

文献信息

• Synthesis of Novel Structurally Simplified Estrogen Analogues with Electron-Donating Groups in Ring A
  作者：Lutz Tietze、Carsten Vock、Ilga Krimmelbein、Linda Nacke

  DOI：10.1055/s-0029-1216810

  日期：2009.6

  A library of 25 novel estrogen analogues were prepared in five to eight steps from mostly commercially available substituted anisoles via bromination, formylation, Corey-Fuchs reaction, elimination, and Sonogashira reaction.

  合成了一系列25种新型雌激素类似物，这些化合物通过五个至八个步骤，主要以市售的取代茴香醚为原料，经过溴化、甲醛化、Corey-Fuchs反应、消除反应及Sonogashira反应制备得到。
• 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF
  申请人：Harada Hironori

  公开号：US20120178735A1

  公开（公告）日：2012-07-12

  Provided is a 2H-chromene compound or a derivative thereof which has an excellent S1P1 agonist action. The 2H-chromene compound or derivative is particularly useful for preventing and/or treating a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells.

  提供了一种2H-色烯化合物或其衍生物，具有优异的S1P1激动剂作用。该2H-色烯化合物或衍生物特别适用于预防和/或治疗由不良淋巴细胞浸润引起的疾病或由细胞异常增殖或堆积引起的疾病。
• 2H-chromene compound and derivative thereof
  申请人：Astellas Pharma Inc.

  公开号：US08193378B2

  公开（公告）日：2012-06-05

  Provided is a compound which has an excellent S1P1 agonist action, and is useful particularly as an active ingredient for an agent for preventing and/or treating a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells. According to the present invention, a 2H-chromene compound or a derivative thereof which has an excellent S1P1 agonist action, and is useful particularly as an active ingredient of an agent for preventing and/or treating a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells can be provided. The 2H-chromene compound and a derivative thereof which are the compounds of the present invention have an S1P1 agonist action, and can be used particularly for prevention and/or treatment of a disease induced by undesirable lymphocyte infiltration or a disease induced by abnormal proliferation or accumulation of cells.

  本发明提供了一种具有出色的S1P1激动剂作用的化合物，特别适用于作为预防和/或治疗由不良淋巴细胞浸润引起的疾病或由细胞异常增殖或堆积引起的疾病的活性成分。根据本发明，可以提供一种具有出色的S1P1激动剂作用的2H-香豆素化合物或其衍生物，特别适用于作为预防和/或治疗由不良淋巴细胞浸润引起的疾病或由细胞异常增殖或堆积引起的疾病的活性成分。本发明的化合物2H-香豆素及其衍生物具有S1P1激动剂作用，特别适用于预防和/或治疗由不良淋巴细胞浸润引起的疾病或由细胞异常增殖或堆积引起的疾病。
• [EN] PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME<br/>[FR] PHÉNALKYLAMINES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：GILGAMESH PHARMACEUTICALS INC

  公开号：WO2022192781A1

  公开（公告）日：2022-09-15

  The present disclosure provides phenalkylamine compounds and their use in treating medical disorders, such as psychiatric diseases and disorders. Pharmaceutical compositions and methods of making various phenalkylamine compounds are provided.

  本公开提供了苯基烷胺化合物及其在治疗医学疾病（如精神科疾病和障碍）中的应用。提供了制备各种苯基烷胺化合物的制药组合物和方法。
• Azetidinecarboxylic acid derivative and medicinal use thereof
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP2371811A2

  公开（公告）日：2011-10-05

  A compound represented by the formula (IC-2), a salt thereof, an N-oxide form thereof, a solvate thereof, a prodrug thereof, or a number of specific compounds and pharmaceutical compositions comprising these compounds. The compound has the ability to combine with an SIP receptor (especially EDG-1, EDG-6 and/or EDG-8). It is useful for the prevention and/or treatment of rejection reactions to transplantation, graft versus host diseases, autoimmune diseases, allergic diseases, neurodegenerative diseases etc.

  由式（IC-2）代表的化合物、其盐、其 N-氧化物形式、其溶液剂、其原药或一些特定化合物以及包含这些化合物的药物组合物。该化合物具有与 SIP 受体（尤其是 EDG-1、EDG-6 和/或 EDG-8）结合的能力。它可用于预防和/或治疗移植排斥反应、移植物抗宿主疾病、自身免疫性疾病、过敏性疾病、神经退行性疾病等。