3-(4-氨基丁基)-2,5-哌嗪二酮 | 78510-21-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-(4-氨基丁基)-2,5-哌嗪二酮
• 英文名称: 3-(4-Aminobutyl)piperazine-2,5-dione
• CAS: 78510-21-1
• 化学式: C₈H₁₅N₃O₂
• 分子量: 185.22
• InChiKey: OGQVYQIZUYYYKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  84.2
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] NANOMATERIALS COMPRISING ESTER-LINKED ACETALS<br/>[FR] NANOMATÉRIAUX COMPRENANT DES ACÉTALS À LIAISON ESTER
  申请人：BEAM THERAPEUTICS INC

  公开号：WO2022140252A1

  公开（公告）日：2022-06-30

  The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

  本公开说明书描述了组合物、制剂、纳米颗粒（如脂质纳米颗粒）和/或纳米材料及其使用方法。
• Piperazine-2,5-diones as TGF-beta inhibitors
  申请人：SOUTHERN RESEARCH INSTITUTE

  公开号：US11505531B2

  公开（公告）日：2022-11-22

  The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-β and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及能够抑制 TGF-β 的哌嗪-2,5-二酮和治疗癌症（例如多发性骨髓瘤和血液恶性肿瘤）的方法，以及使用这些化合物治疗纤维化病症的方法。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本发明的限制。
• PIPERAZINE-2,5-DIONES AS TGF-BETA INHIBITORS
  申请人：Southern Research Institute

  公开号：US20210323933A1

  公开（公告）日：2021-10-21

  The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-β and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• [EN] PIPERAZINE-2,5-DIONES AS TGF-BETA INHIBITORS<br/>[FR] PIPÉRAZINE-2,5-DIONES EN TANT QU'INHIBITEURS DE TGF-BÊTA
  申请人：SOUTHERN RES INST

  公开号：WO2020033317A1

  公开（公告）日：2020-02-13

  The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-β and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.