4-hydroxy-3-methoxy-2-nitro-benzoic acid | 89942-87-0

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-hydroxy-3-methoxy-2-nitro-benzoic acid
• 英文别名: 4-Hydroxy-3-methoxy-2-nitro-benzoesaeure；2-Nitro-4-oxy-3-methoxy-benzoesaeure；2-Nitro-vanillinsaeure；2-Nitro-3-methoxy-4-hydroxy-benzoesaeure；4-Hydroxy-3-methoxy-2-nitrobenzoic acid；4-hydroxy-3-methoxy-2-nitrobenzoic acid
• CAS: 89942-87-0
• 化学式: C₈H₇NO₆
• 分子量: 213.147
• InChiKey: WKDKRUDEBWZFFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-hydroxy-3-methoxy-2-nitro-benzoic acid 在 硫酸 作用下， 生成 3-硝基-1,2-苯二醇
  参考文献：
  名称：

  Treatment of Affective Disorder and Obesity with Topiramate

  摘要：

  以下是您请求的翻译结果：

  报告一例使用抗癫痫药物托吡酯治疗的患者的体重减轻和情绪稳定案例。

  一位37岁的肥胖白人女性，情绪不稳定且肥胖，正在接受辅助托吡酯治疗。患者在接受托吡酯治疗的10周内体重减轻了10公斤，并且临床状况有所改善，这从她需要被送入管理单位进行持续观察的次数减少以及需要机械约束或药物干预的激烈爆发次数减少中得到证明。此外，在接受托吡酯治疗期间，患者成功完成了两次家庭访问，并且在撰写本文时，她正在进行第三次家庭访问，已经出院。

  这个案例进一步强化了之前的报告，即托吡酯可能有助于治疗情感障碍以及在体重增加常见的人群中诱导体重减轻。本案例报告中的患者没有急性疾病或健康状况的变化，饮食没有变化，也没有药物变化，这些都不可能导致突然的体重减轻。此外，患者的行为在足疗程的试验期间，将托吡酯作为辅助治疗加入丙戊酸、西酞普兰和氯丙嗪后才有改善。

  需要进行控制研究，以评估托吡酯在精神病患者中的使用，特别是对于额外诊断为肥胖的精神病患者，托吡酯治疗的益处。

  DOI：

  10.1345/aph.10027
• 作为产物：
  描述：

  4-乙酰氧基-3-甲氧基苯甲酸 在 硝酸 作用下， 生成 4-hydroxy-3-methoxy-2-nitro-benzoic acid
  参考文献：
  名称：

  Klemenc, Monatshefte fur Chemie, 1914, vol. 35, p. 95

  摘要：

  DOI：

文献信息

• Tiemann; Matsmoto, Chemische Berichte, 1876, vol. 9, p. 943
  作者：Tiemann、Matsmoto

  DOI：——

  日期：——
• A new exhalite type—siderite-sericite chert formed in fault-controlled lacustrine basin
  作者：Jianming Liu、Jie Ye、Anli Zhang、Yuwang Wang、Neng Jiang

  DOI：10.1007/bf02906864

  日期：2001.12

  On the basis of geological, fabric, lithographical and mineralogical study, a new exhalite type, called 'siderite-sericite chert' according to its mineral assemblage, was reported for the first time. It was formed in a fault-controlled lacustrine basin and closely associated with sulfide ore characteristic of complex metal assemblage of Sn-Ag-Cu-Pb-Zn. Its geological setting, mineral assemblage, as well as associated ores are quite unique, and therefore worthy of detailed research. In the Dajing deposit, Linxi County, Inner Mongolia, it is this very exhalite that is regarded as a kind of acidic subvolcanic dike till now, and because of this, a genetic model of hydrothermal epigenetic filling by subvolcanic fluid prevails over the Dajing deposit. It is demonstrated again that any geochemical study might be senseless without support of detailed geological and lithographical investigations. This is of particular importance at the present time when one is readily confused by various modern techniques.
• Treatment of Affective Disorder and Obesity with Topiramate
  作者：Christian J Teter、John J Early、Carol M Gibbs

  DOI：10.1345/aph.10027

  日期：2000.11

  To report a case of weight loss and mood stabilization in a patient being treated with the antiepileptic drug topiramate.

  A 37-year-old obese white woman with affective instability and obesity was being treated with adjunctive topiramate therapy. The patient lost 10 kg over 10 weeks of treatment with topiramate and improved clinically, as evidenced by a reduction in the number of × that she had to be admitted to a management unit for constant observation, and a decrease in the number of × that mechanical restraints or medication interventions were required for aggressive outbursts. Furthermore, the patient successfully completed two home visits while receiving topiramate therapy and was out of the hospital on her third home visit at the time of this writing.

  This case further strengthens previous reports that topiramate may be useful in treating affective disorders as well as inducing weight loss in a patient population in which weight gain is common. The patient discussed in this case report had no acute illnesses or changes in health status, no changes in diet, and no changes in her medications that could have accounted for the sudden weight loss. In addition, the patient's behavior did not improve until topiramate was added as adjunctive therapy of valproic acid, citalopram, and chlorpromazine during an adequate trial period.

  Controlled studies need to be performed to evaluate the use of topiramate in the psychiatric population and, in particular, the benefits of topiramate therapy in psychiatric patients with an additional diagnosis of obesity.

  以下是您请求的翻译结果：

  报告一例使用抗癫痫药物托吡酯治疗的患者的体重减轻和情绪稳定案例。

  一位37岁的肥胖白人女性，情绪不稳定且肥胖，正在接受辅助托吡酯治疗。患者在接受托吡酯治疗的10周内体重减轻了10公斤，并且临床状况有所改善，这从她需要被送入管理单位进行持续观察的次数减少以及需要机械约束或药物干预的激烈爆发次数减少中得到证明。此外，在接受托吡酯治疗期间，患者成功完成了两次家庭访问，并且在撰写本文时，她正在进行第三次家庭访问，已经出院。

  这个案例进一步强化了之前的报告，即托吡酯可能有助于治疗情感障碍以及在体重增加常见的人群中诱导体重减轻。本案例报告中的患者没有急性疾病或健康状况的变化，饮食没有变化，也没有药物变化，这些都不可能导致突然的体重减轻。此外，患者的行为在足疗程的试验期间，将托吡酯作为辅助治疗加入丙戊酸、西酞普兰和氯丙嗪后才有改善。

  需要进行控制研究，以评估托吡酯在精神病患者中的使用，特别是对于额外诊断为肥胖的精神病患者，托吡酯治疗的益处。

• Klemenc, Monatshefte fur Chemie, 1914, vol. 35, p. 95
  作者：Klemenc

  DOI：——

  日期：——