N-acetyl-N'-propylethylenediamine | 4814-87-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-N'-propylethylenediamine
• 英文别名: N-Propyl-N'-acetyl-ethylendiamin；N-[2-(propylamino)ethyl]acetamide
• CAS: 4814-87-3
• 化学式: C₇H₁₆N₂O
• mdl: MFCD11162615
• 分子量: 144.217
• InChiKey: FZDUHERZMZPXOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-丙基亚乙基二胺 、 N-acetyl-N-(2-(trifluoromethyl)phenyl)acetamide 以 乙醇 为溶剂， 反应 12.0h， 以93%的产率得到N-acetyl-N'-propylethylenediamine
  参考文献：
  名称：

  The ortho-substituted N,N-diacetylaniline as a selective acetylating reagent

  摘要：

  Selective acetylation of the less hindered amino group in the presence of the more hindered amino group with the use of 2-trifluoromethyl-N,N-diacetylaniline 2c is described. This acetylation with 2c yielded the corresponding less hindered monoacetamide exclusively, simply, conveniently, and in good yields. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00745-4

文献信息

• N-Acyl-4,5-dihydro-4,4-dimethyl-N-methyl-2-thiazolamine as a chemoselective acylating agent
  作者：Taek Hyeon Kim、Garp-Yeol Yang

  DOI：10.1016/s0040-4039(02)02414-0

  日期：2002.12

  2-Methylamino-2-thiazoline reacted with alkyl acyl halides to produce N-acyl-2-methylamino-2-thiazolines, exo-acylated product regioselectively, which were found to be highly chemoselective acylating agents for primary amine in the presence of secondary amine and for the less sterically hindered of two different primary amines.

  2-甲基氨基-2-噻唑啉与烷基酰卤反应以产生Ñ酰基-2-甲基氨基-2-噻唑啉，外切-acylated产品区域选择性，这被认为是在仲胺的存在下伯胺高度化学选择性的酰化剂以及两种不同的伯胺在空间上受阻较小。
• POLYMER BASED POLYNUCLEOTIDE TRANSFECTION AGENTS
  申请人：Intezyne Technologies, Inc.

  公开号：US20140302607A1

  公开（公告）日：2014-10-09

  The present invention provides a methodology for transfecting cells in vitro. In particular, cationic polymers and polynucleotide containing polyplexes comprising such polymers are provided.

  本发明提供了一种体外细胞转染方法。具体而言，提供了含有阳离子聚合物和聚核苷酸的聚合物复合物的方法。
• CONTROLLED POLYPLEX ASSEMBLY
  申请人：Mirosevich Janni

  公开号：US20110256227A1

  公开（公告）日：2011-10-20

  The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, polyplexes comprising polycations, polyanions, and polynucleotides are provided. The invention further provides methods of making and using said polyplexes.
• PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY
  申请人：MIROSEVICH JANNI

  公开号：US20110229528A1

  公开（公告）日：2011-09-22

  The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.
• COMPOSITIONS FOR LABELING AND IDENTIFYING AUTOPHAGOSOMES AND METHODS FOR MAKING AND USING THEM
  申请人：Gottlieb Roberta A.

  公开号：US20120042398A1

  公开（公告）日：2012-02-16

  The invention provides methods and compositions for detecting and measuring the amount of autophagosomes in cells or tissues, including biopsy samples, in vitro, in situ and/or in vivo. By detecting and measuring the amount of autophagosomes in cells or tissues, the methods and compositions of the invention also measure the amount of autophagic activity in a cell or a tissue. In one aspect, the invention can be adapted to a plate-reader format for high-throughput screening of drugs that modulate autophagy, i.e., high-throughput detection of autophagic (autophagosome) activity in cells or tissues. In alternative embodiments, the compositions of the invention can localize into autophagosomes (AV), and these compositions can comprise any detectable moiety or group, e.g., a cadaverine, a radioactive, fluorescent-, bioluminescent and/or paramagnetic-conjugated reagent.