6-(Methoxymethyl)pyridine-2-carbonitrile | 220108-44-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(Methoxymethyl)pyridine-2-carbonitrile
• CAS: 220108-44-1
• 化学式: C₈H₈N₂O
• 分子量: 148.164
• InChiKey: RUWYONXVHJURFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  45.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  D-苯甘氨醇 、 6-(Methoxymethyl)pyridine-2-carbonitrile 在 甲醇 、 硫酸 、 sodium methylate 作用下， 生成 (4'R)-2-(3',4'-dihydro-4'-phenyl-2'-oxazolyl)-6-(methoxymethyl)pyridine
  参考文献：
  名称：

  Palladium-catalyzed allylic alkylation using pyridino-oxazolines and quinolino-oxazolines as ligands—influence of steric factors

  摘要：

  Four new chiral pyridino- and quinolino-oxazolines were subjected to the palladium-catalyzed alkylation of 1,3-diphenyl-2-propenyl acetate. The enantioselectivity varied (82-88% ee) with the steric properties of the ligands. The results are discussed in connection with results previously obtained using analogous ligands. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00346-2
• 作为产物：
  描述：

  在 氢氟酸 、 sodium hydride 作用下， 以 乙腈 为溶剂， 生成 6-(Methoxymethyl)pyridine-2-carbonitrile
  参考文献：
  名称：

  Palladium-catalyzed allylic alkylation using pyridino-oxazolines and quinolino-oxazolines as ligands—influence of steric factors

  摘要：

  Four new chiral pyridino- and quinolino-oxazolines were subjected to the palladium-catalyzed alkylation of 1,3-diphenyl-2-propenyl acetate. The enantioselectivity varied (82-88% ee) with the steric properties of the ligands. The results are discussed in connection with results previously obtained using analogous ligands. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00346-2