(R)-N-((R)-2-methoxy-1-phenylethyl)-1-phenylpropylamine | 256408-45-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-N-((R)-2-methoxy-1-phenylethyl)-1-phenylpropylamine
• 英文别名: (1R)-N-[(1R)-2-methoxy-1-phenylethyl]-1-phenylpropan-1-amine
• CAS: 256408-45-4
• 化学式: C₁₈H₂₃NO
• 分子量: 269.387
• InChiKey: KROHSJRHJJDXDR-MSOLQXFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-N-((R)-2-methoxy-1-phenylethyl)-1-phenylpropylamine 在 三溴化硼 、 高碘酸 、 甲胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 17.0h， 生成 (R)-(+)-1-苯丙胺
  参考文献：
  名称：

  Asymmetric Synthesis of Allyl- and α-Allenylamines from Chiral Imines and Alkynes via (η²-Imine)Ti(O-i-Pr)₂ Complexes

  摘要：

  [GRAPHICS]The reaction of a divalent titanium reagent Ti(O-1-Pr)(4)/2i-PrMgX with optically active arylaidimines derived from arylaidehydes and O-methylphenylglycinol provided, in a highly diastereoselective manner, chiral (eta(2)-imine)Ti(O-i-Pr)(2) complexes, which in turn reacted with 1-alkynes or propargyl compounds to give optically active allyl- and alpha-allenylamines, respectively.

  DOI：

  10.1021/ol034599u
• 作为产物：
  描述：

  在 palladium dihydroxide 氢气 作用下， 以 甲醇 为溶剂， 反应 0.33h， 生成 (R)-N-((R)-2-methoxy-1-phenylethyl)-1-phenylpropylamine
  参考文献：
  名称：

  Asymmetric Synthesis of Allyl- and α-Allenylamines from Chiral Imines and Alkynes via (η²-Imine)Ti(O-i-Pr)₂ Complexes

  摘要：

  [GRAPHICS]The reaction of a divalent titanium reagent Ti(O-1-Pr)(4)/2i-PrMgX with optically active arylaidimines derived from arylaidehydes and O-methylphenylglycinol provided, in a highly diastereoselective manner, chiral (eta(2)-imine)Ti(O-i-Pr)(2) complexes, which in turn reacted with 1-alkynes or propargyl compounds to give optically active allyl- and alpha-allenylamines, respectively.

  DOI：

  10.1021/ol034599u

文献信息

• Diastereoselective allylation and alkylation of optically active imines with metallic samarium and a catalytic amount of iodine
  作者：Reiko Yanada、Nobuyuki Negoro、Masanori Okaniwa、Toshiro Ibuka

  DOI：10.1016/s0040-4020(99)00854-6

  日期：1999.12

  Barbier-type allylation and alkylation of optically active imines such as N-benzylidenevalinol methyl ether was performed with metallic samarium, a catalytic amount of iodine, and allyl or alkyl halides. This reaction proceeded in a highly diastereoselective manner in THF at room temperature.

  用金属sa，催化量的碘和烯丙基或烷基卤化物进行光学活性的亚胺如N-苄叉亚戊醇甲基醚的Barbier型烯丙基化和烷基化。该反应在室温下以高度非对映选择性的方式进行。
• Asymmetric Synthesis of Allyl- and α-Allenylamines from Chiral Imines and Alkynes via (η²-Imine)Ti(O-<i>i</i>-Pr)₂ Complexes
  作者：Kohki Fukuhara、Sentaro Okamoto、Fumie Sato

  DOI：10.1021/ol034599u

  日期：2003.6.1

  [GRAPHICS]The reaction of a divalent titanium reagent Ti(O-1-Pr)(4)/2i-PrMgX with optically active arylaidimines derived from arylaidehydes and O-methylphenylglycinol provided, in a highly diastereoselective manner, chiral (eta(2)-imine)Ti(O-i-Pr)(2) complexes, which in turn reacted with 1-alkynes or propargyl compounds to give optically active allyl- and alpha-allenylamines, respectively.