Cyclopentadecan-carbonsaeure | 3667-66-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cyclopentadecan-carbonsaeure
• 英文别名: Cylopentadecancarbonsaeure；Cyclopentanoncarbonsaure；cyclopentadecanecarboxylic acid
• CAS: 3667-66-1
• 化学式: C₁₆H₃₀O₂
• 分子量: 254.413
• InChiKey: HNZZQRFFPLRAFU-UHFFFAOYSA-N

物化性质

• 熔点：
  52-54 °C
• 沸点：
  392.0±10.0 °C(Predicted)
• 密度：
  0.914±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Cyclopentadecan-carbonsaeure 在 硫酸 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 甲苯 为溶剂， 反应 32.0h， 生成
  参考文献：
  名称：

  WO2024106715A1

  摘要：

  公开号：
• 作为产物：
  描述：

  bicyclo<9.4.1>hexadecan-16-one 生成 Cyclopentadecan-carbonsaeure
  参考文献：
  名称：

  基于1,5,9-环十二碳三烯的exaltone和dl-muscone的合成

  摘要：

  双环[9•4•1]十六烷-16-酮是由环十二酮通过乙氧基羰基化、与1,4-二溴丁烷缩合、皂化和脱羧四个步骤制备的。双环酮的光解产生乙烯酮，该乙烯酮被甲醇捕获以提供环十五烷羧酸甲酯或直接氧化为 exaltone。该酯也通过五个步骤转化为 exaltone。dl-Muscone 是通过以 14-甲基双环-[10•3•1]十六烷-16-one 作为关键中间体对环十三烷酮应用相同的方案制备的。

  DOI：

  10.1139/v69-179

文献信息

• METHOD FOR THE PRODUCTION OF BORONIC ACIDS CARRYING CYANOALKYL, CARBOXYL AND AMINOCARBONYL GROUPS AND THEIR DERIVATIVES
  申请人：Meudt Andreas

  公开号：US20090286995A1

  公开（公告）日：2009-11-19

  A process for the manufacture of aminocarbonyl boronic acids of formula (IV) by converting the compounds of formula (III) with a Brønsted base Y(OH) n in a solvent or a solvent mixture, in which Z represents an optionally substituted arylene, heteroarylene, alkene, heteroalkene, alkylidene, heteroalkylidene, alkenylidene, heteroalkenylidene, alkynylidene, arylalkylene, heteroarylalkylene, arylheteroalkylene, heteroarylheteroalkylene, alkylheteroarylene, heteroalkylheteroarylene, or alkylarylene group; Y represents a metal or ammonium cation of valence n with 0

  一种通过将化合物的公式（III）与Brønsted碱Y（OH）在溶剂或溶剂混合物中转化为氨基羰基硼酸（IV）的制备方法，其中Z代表可选择取代的芳基、杂芳基、烯烃、杂烯烃、烷基亚烯、杂烷基亚烯、烯基亚烯、杂烯基亚烯、炔基亚烯、芳基烷基亚烯、杂芳基烷基亚烯、芳基杂烷基亚烯、杂芳基杂烷基亚烯、烷基杂芳基、杂烷基杂芳基或烷基芳基基团；Y代表价数为0
• Regio-controllable [2+2] benzannulation with two adjacent C(sp ³ )–H bonds
  作者：Ji-Min Yang、Yu-Kun Lin、Tao Sheng、Liang Hu、Xin-Pei Cai、Jin-Quan Yu

  DOI：10.1126/science.adg5282

  日期：2023.5.12

  amide-pyridone ligands, to achieve a regio-controllable synthesis of BCBs through a formal [2+2] cycloaddition involving σ bonds only (two C–H bonds and two aryl–halogen bonds). A wide range of cyclic and acyclic aliphatic acids, as well as dihaloheteroarenes, are compatible, generating diversely functionalized BCBs and hetero-BCBs present in drug molecules and bioactive natural products.

  不饱和碳化合物之间的传统环加成反应中的区域控制通常具有挑战性。现代药物化学对苯并环丁烯 (BCB) 支架的日益关注表明，需要寻找替代的、更具选择性的途径来制备富含 C(sp 3 ） 特点。在这里，我们报道了由二齿酰胺-吡啶酮配体实现的钯催化的羧酸中两个相邻亚甲基单元的双C-H活化，通过涉及σ的正式[2+2]环加成实现了BCB的区域可控合成。仅键（两个 C-H 键和两个芳基-卤素键）。多种环状和无环脂肪酸以及二卤杂芳烃是相容的，可生成药物分子和生物活性天然产物中存在的多种功能化的 BCB 和杂 BCB。
• Synthesis and Biological Evaluation of Antimetastatic Agents Predicated upon Dihydromotuporamine C and Its Carbocyclic Derivatives
  作者：Aaron Muth、Veethika Pandey、Navneet Kaur、Melissa Wason、Cheryl Baker、Xianlin Han、Teresa R. Johnson、Deborah A. Altomare、Otto Phanstiel

  DOI：10.1021/jm401906v

  日期：2014.5.22

  The motuporamines isolated from the sea sponge Xestospongia exigua are of biological interest because of their unique antimigration and antiangiogenic properties. Key bioactive features were found to be a saturated 15-membered heterocycle and a norspermidine motif. This paper describes new analogues that modulate the cytotoxicity of this compound class and have enhanced antimigration properties. By movement of the polyamine chain outside the ring, new carbocycles were discovered that doubled the antimigration potency and reduced compound toxicity by 133-fold. Mice injected with metastatic human L3.6pl pancreatic cancer cells demonstrated significant reduction in liver metastases when treated with N-1-(3-aminopropyl)-N-3-(cyclopentadecylmethyl)propane-1,3-diamine compared with dihydromotuporamine C. Significant changes in specific ceramide populations (N16:0 and N22:1) were noted in L3.6pl cells treated with dihydromotuporamine C but not for the cyclopentadecylmethylnorspermidine derivative, which had lower toxicity. Both compounds gave increased levels of specific low molecular weight sphingomyelins, suggesting that they may act upon sphingomyelin processing enzymes.
• NOKAMI JUNZO; MATSUURA NOBUYOSHI; SUEOKA TATSUFUMI; KUSUMOTO YOSHIHISA; K+, CHEM. LETT., 1978, NO 11, 1283-1284
  作者：NOKAMI JUNZO、 MATSUURA NOBUYOSHI、 SUEOKA TATSUFUMI、 KUSUMOTO YOSHIHISA、 K+

  DOI：——

  日期：——
• RESIST COMPOSITION AND PATTERNING PROCESS
  申请人：Hatakeyama Jun

  公开号：US20120202153A1

  公开（公告）日：2012-08-09

  A resist composition comprising a polymer having recurring units having an acid labile group and recurring units of a magnesium, copper, zinc or cesium salt of (meth)acrylic acid, styrenecarboxylic acid or vinylnaphthalenecarboxylic acid copolymerized together exhibits a high resolution, high sensitivity, and minimal LER. The resist composition is best suited as the patterning material for VLSIs and photomasks.