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1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]- | 655247-77-1

中文名称
——
中文别名
——
英文名称
1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-
英文别名
3-[1-(3-aminopropyl)indol-3-yl]pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-化学式
CAS
655247-77-1
化学式
C15H15N3O2
mdl
——
分子量
269.3
InChiKey
UTLDXEFFHOVUDQ-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.4
  • 重原子数:
    20
  • 可旋转键数:
    4
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.2
  • 拓扑面积:
    77.1
  • 氢给体数:
    2
  • 氢受体数:
    3

文献信息

  • Medium and method for enriching, purifying or depleting atp binding proteins from a pool of proteins
    申请人:Godl Klaus
    公开号:US20060105445A1
    公开(公告)日:2006-05-18
    The present invention relates to a medium and a method for enriching ATP binding proteins, e.g. proteinkinases, from a pool of proteins, like a proteome. The medium of the present invention comprises specific inhibitors, e.g. at least one of the compounds 4-[4-(4-fluoro-phenyl)-5-pyridine-4-yl-1H-imidazole-2-yl]-benzylamine, 2-[4-(2-Amino-ethoxy)-phenylamino]-6-(2,6-dichloro-phenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one, 2-[1-(3-aminopropyl)-1H-indole-3-yl)maleinmide, 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-3-(1H-indol 3-yl)-maleinmide, 3-[1-(3-Aminopropyl)-1H-indol-3-yl]4-(1-methyl-1H-indol-3-yl) maleinimide, 3-(8-Aminomethyl-6,7,8,9-tetrahydropyrido-[1,2-a]-indol-10-yl) (1-methyl-1H-indol -3-yl)-maleinmide, [6-(3-Amino-propoxy)-methoxy-quinazolin-4-yl]-(3-chloro-phenyl)-amine, 6-(3-Amino-propoxy)-7-methoxy-quinazolin-4-yl-(3-chloro-4-fluoro-phenyl)-amine, 6-(3Amino-propoxy)-7-methoxy-quinazolin-4-yl]-(3-bromo-phenyl)-amine and 4-[4-(4-Amino-butyl)-piperazin-1-yl-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide immobilized on a support material. According to the method of the present invention the above-mentioned immobilized compounds are used to selectively bind protein kinases from a pool of heterogeneous proteins.
    本发明涉及一种从蛋白质池(如蛋白质组)中富集ATP结合蛋白质(如蛋白激酶)的介质和方法。本发明的介质包括特定的抑制剂,例如以下至少一种化合物:4-[4-(4-氟苯基)-5-吡啶基-4-基]-1H-咪唑-2-基]苯甲胺,2-[4-(2-氨基乙氧基)-苯基氨基]-6-(2,6-二氯苯基)-8-甲基-8H-吡啶[2,3-d]嘧啶-7-酮,2-[1-(3-氨丙基)-1H-吲哚-3-基]马来酰亚胺,3-[1-(3-氨丙基)-1H-吲哚-3-基]-3-(1H-吲哚-3-基)-马来酰亚胺,3-[1-(3-氨丙基)-1H-吲哚-3-基]4-(1-甲基-1H-吲哚-3-基)马来酰亚胺,3-(8-氨甲基-6,7,8,9-四氢吡啶[1,2-a]-吲哚-10-基)(1-甲基-1H-吲哚-3-基)-马来酰亚胺,[6-(3-氨基丙氧基)-甲氧基喹唑啉-4-基]-(3-氯苯基)-胺,6-(3-氨基丙氧基)-7-甲氧基喹唑啉-4-基-(3-氯-4-氟苯基)-胺,6-(3-氨基丙氧基)-7-甲氧基喹唑啉-4-基]-(3-溴苯基)-胺和4-[4-(4-氨基丁基)-哌嗪-1-基甲基]-N-[4-甲基-3-(4-吡啶-3-基-嘧啶-2-基氨基)-苯基]-苯甲酰胺,这些化合物被固定在支持材料上。根据本发明的方法,上述固定化化合物被用于从杂多蛋白质池中选择性地结合蛋白激酶。
  • METHOD FOR ISOLATING ATP BINDING PROTEINS BY MEANS OF IMMOBILIZED PROTEIN INHIBITORS
    申请人:Axxima Pharmaceuticals AG
    公开号:EP1527345A2
    公开(公告)日:2005-05-04
  • [EN] MEDIUM AND METHOD FOR ENRICHING, PURIFYING OR DEPLETING ATP BINDING PROTEINS FROM A POOL OF PROTEINS<br/>[FR] MILIEU ET METHODE D'ENRICHISSEMENT, DE PURIFICATION OU D'APPAUVRISSEMENT DE PROTEINES DE LIAISON A L'ATP A PARTIR D'UN RESERVOIR DE PROTEINES
    申请人:AXXIMA PHARMACEUTICALS AG
    公开号:WO2004013633A2
    公开(公告)日:2004-02-12
    The present invention relates to a medium and a method for enriching ATP binding proteins, e.g. proteinkinases, from a pool of proteins, like a proteome. The medium of the present invention comprises specific inhibitors, e.g. at least one of the compounds 4-[4-(4-fluoro­-phenyl)-5-pyridine-4-yl-lH-imidazole-2-yl]-benzylamine, 2-[4-(2-Amino-ethoxy)­- phenylamino]-6-(2,6-dichloro-phenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one, 2-[1-(3­-aminopropyl)-1H-indole-3-yl)maleimide, 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-3-(1H-indol­ 3-yl)-maleinmide, 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-lH-indol-3-yl) maleinimide, 3-(8-Aminomethyl-6,7,8,9-tetrahydropyrido-[1,2-a]-indol-10-yl)-4-(1-methyl-lH-indol -3-y1)-maleinmide, [6-(3-Amino-propoxy)-methoxy-quinazolin-4-yl]-(3-chloro-phenyl)-amine, 6-(3-Amino-propoxy)-7-methoxy-quinazolin-4-yl-(3-chloro-4-fluoro-phenyl)-amine, 6-(3­Amino-propoxy)-7-methoxy-quinazolin-4-yl]-(3-bromo-phenyl)-amine and 4-[4-(4-Amino-butyl)-piperazin-l-yl-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide immobilized on a support material. According to the method of the present invention the above-mentioned immobilized compounds are used to selectively bind protein kinases (e.g. p38, JNK1, JNK2, CK18, RICK, GAK) from a pool of heterogeneous proteins.
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