3-(4-苯基苯基)环己-2-烯-1-醇 | 625445-10-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(4-苯基苯基)环己-2-烯-1-醇
• 英文名称: 3-Biphenyl-4-yl-cyclohex-2-enol
• 英文别名: 3-(4-phenylphenyl)cyclohex-2-en-1-ol
• CAS: 625445-10-5
• 化学式: C₁₈H₁₈O
• 分子量: 250.34
• InChiKey: LMQVEIIXXGVXKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(4-苯基苯基)环己-2-烯-1-醇 在 盐酸 、 氧气 、 亚甲兰 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 18.0h， 生成 (4aS,8aS)-8-(4-phenylphenyl)spiro[4a,5,6,8a-tetrahydro-1,2,4-benzotrioxine-3,1'-cyclohexane]
  参考文献：
  名称：

  Photooxygenation of 3-aryl-2-cyclohexenols: synthesis of a new series of antimalarial 1,2,4-trioxanes

  摘要：

  Using easily accessible 3-aryl-2-cyclohexenols, a photooxygenation route for the preparation of bicyclic 1.2.4-trioxanes is reported. Several of these trioxanes have shown significant antimalarial activity again against multidrug resistant Plasmodium yoelii mice by the oral route. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.11.078
• 作为产物：
  描述：

  3-(4-苯基苯基)环己-2-烯-1-酮 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 3-(4-苯基苯基)环己-2-烯-1-醇
  参考文献：
  名称：

  Photooxygenation of 3-aryl-2-cyclohexenols: synthesis of a new series of antimalarial 1,2,4-trioxanes

  摘要：

  Using easily accessible 3-aryl-2-cyclohexenols, a photooxygenation route for the preparation of bicyclic 1.2.4-trioxanes is reported. Several of these trioxanes have shown significant antimalarial activity again against multidrug resistant Plasmodium yoelii mice by the oral route. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.11.078

文献信息

• Palladium-Catalyzed Borylative Cyclization and Cyclopropanation of Terminal Alkyne-Derived Enynes
  作者：Duhao Sun、Bing Zhou、Lanqin Liu、Xiaoyun Chen、Hong Hou、Ying Han、Chaoguo Yan、Yaocheng Shi、Shaoqun Zhu

  DOI：10.1021/acs.orglett.3c01551

  日期：2023.6.30

  Described herein is a palladium-catalyzed borylative cyclization and cyclopropanation of terminal alkyne-derived enynes, affording borylated bicycles, fused cycles, and bridged cycles in good isolated yields. The synthetic utility of this protocol was fully demonstrated by large scale reaction and synthetic derivatization of the borate group.

  本文描述的是末端炔衍生的烯炔的钯催化的硼化环化和环丙烷化，以良好的分离收率提供硼化双环、稠合环和桥环。通过硼酸基团的大规模反应和合成衍生化，充分证明了该方案的合成实用性。
• Photooxygenation of 3-aryl-2-cyclohexenols: synthesis of a new series of antimalarial 1,2,4-trioxanes
  作者：Chandan Singh、Nitin Gupta、Sunil K. Puri

  DOI：10.1016/j.tetlet.2004.11.078

  日期：2005.1

  Using easily accessible 3-aryl-2-cyclohexenols, a photooxygenation route for the preparation of bicyclic 1.2.4-trioxanes is reported. Several of these trioxanes have shown significant antimalarial activity again against multidrug resistant Plasmodium yoelii mice by the oral route. (C) 2004 Elsevier Ltd. All rights reserved.