3-(4-苯氧基苯基)丙-2-烯酸 | 2215-83-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(4-苯氧基苯基)丙-2-烯酸
• 英文名称: 4-phenoxycinnamic acid
• 英文别名: (E)-3-(4-phenoxyphenyl)acrylic acid；3-(4-phenoxyphenyl)acrylic acid；p-phenoxycinnamic acid；4-phenoxy-trans-cinnamic acid；4-Phenoxy-trans-zimtsaeure；2-Propenoic acid, 3-(4-phenoxyphenyl)-；(E)-3-(4-phenoxyphenyl)prop-2-enoic acid
• CAS: 2215-83-0
• 化学式: C₁₅H₁₂O₃
• mdl: MFCD02180633
• 分子量: 240.258
• InChiKey: XWGDODCEQXQAFQ-DHZHZOJOSA-N

物化性质

• 熔点：
  155-157 °C(Solv: methanol (67-56-1))
• 沸点：
  405.4±28.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  3-(4-苯氧基苯基)丙-2-烯酸 在 4-二甲氨基吡啶 、 氟化氢吡啶 、 达卡巴嗪 作用下， 以 二氯甲烷 、 甲苯 、 乙腈 为溶剂， 生成 [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-15-[(E)-3-(4-phenoxyphenyl)prop-2-enoyl]oxy-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
  参考文献：
  名称：

  Targeting FtsZ for Antituberculosis Drug Discovery:  Noncytotoxic Taxanes as Novel Antituberculosis Agents

  摘要：

  Screening of 120 taxanes identified a number of compounds that exhibited significant antituberculosis activity. Rational optimization of selected compounds led to the discovery that the C-seco-taxane-multidrug-resistance (MDR) reversal agents (C-seco-TRAs) are non-cytotoxic at the upper limit of solubility and detection (> 80 mu M), while maintaining MIC99 values of 1.25-2.5 mu M against drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis (MTB). Treatment of MTB cells with TRA 3aa and 10a at the MIC caused filamentation and prolongation of the cells, a phenotypic response to FtsZ inactivation.

  DOI：

  10.1021/jm050920y
• 作为产物：
  描述：

  4-甲基二苯基醚 在 potassium permanganate 、 Pd-BaSO₄ 、 五氯化磷 、 水 、 sodium acetate 、 甲苯 作用下， 生成 3-(4-苯氧基苯基)丙-2-烯酸
  参考文献：
  名称：

  Lock; Kempter, Monatshefte fur Chemie, 1936, vol. 67, p. 24,35

  摘要：

  DOI：

文献信息

• AMINO ACID DERIVATIVE
  申请人：Ookubo Tomohiro

  公开号：US20110172442A1

  公开（公告）日：2011-07-14

  The amino acid derivative of the present invention provides a novel compound that shows excellent analgesic action. The amino acid derivative of the present invention is a novel compound that shows excellent analgesic action to not only a model animal for nociceptive pains but also a model animal for neuropathic pains, so that the amino acid derivative is very useful as a drug for treating various pain diseases.

  本发明的氨基酸衍生物提供了一种显示出优异镇痛作用的新化合物。本发明的氨基酸衍生物是一种新化合物，不仅对于模拟伤害性疼痛的动物模型，而且对于模拟神经病理性疼痛的动物模型都显示出优异的镇痛作用，因此该氨基酸衍生物作为治疗各种疼痛疾病的药物非常有用。
• Isoxazole compounds useful for the prophylaxis or treatment of nervous
  申请人：Sankyo Company, Limited

  公开号：US06005116A1

  公开（公告）日：1999-12-21

  Isoxazole compounds having the following general formula: ##STR1## wherein R.sup.1 represents an optionally substituted aryl group or aromatic heterocyclic group; R.sup.2 represents a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, an alkoxy group, a cyano group, a carboxyl group, an alkanoyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group; R.sup.3 represents an optionally substituted amino group or a saturated heterocyclic group; X represents an oxygen atom or a sulfur atom; and n is an integer of from 2 to 6. These compounds have excellent monoamine oxidase inhibitory activity and are useful as a therapeutic agent or a preventive agent against nervous diseases such as depression.

  异噁唑化合物具有以下一般式：##STR1##其中R.sup.1代表可选择取代的芳基或芳香杂环基；R.sup.2代表氢原子、卤素原子、可选择取代的烷基、烯基、炔基、环烷基、环烯基、烷氧基、氰基、羧基、烷酰基、烷氧羰基或可选择取代的氨基甲酰基；R.sup.3代表可选择取代的氨基或饱和杂环基；X代表氧原子或硫原子；n为2到6的整数。这些化合物具有优异的单胺氧化酶抑制活性，并可用作治疗剂或预防剂，用于抑郁等神经疾病。
• Structural isomers of cinnamic hydroxamic acids block HCV replication via different mechanisms
  作者：Maxim V. Kozlov、Konstantin A. Konduktorov、Alsu Z. Malikova、Kamila A. Kamarova、Anastasia S. Shcherbakova、Pavel N. Solyev、Sergey N. Kochetkov

  DOI：10.1016/j.ejmech.2019.111723

  日期：2019.12

  A set of ortho-, meta- and para-substituted cinnamic hydroxamic acids (CHAs) was synthesized. In each series of structural isomers, a phenyl substituent was linked to an aromatic ring of the parent cinnamic acid via a linker of one to four atoms in length. Using a cell test system with the full-length replicon of hepatitis C virus (HCV), we established a relationship between the suppression of HCV

  合成了一组邻，间和对位的肉桂酸异羟肟酸（CHA）。在各系列结构异构体中，苯基取代基通过长度为1-4个原子的连接基与母体肉桂酸的芳环连接。使用带有丙型肝炎病毒全长复制子的细胞测试系统，我们建立了抑制HCV复制子繁殖与抑制I / IIb类组蛋白脱乙酰基酶（HDAC）之间的关系。在邻位CHA的情况下，抗HCV活性与HDAC8的抑制作用有关，而在meta-CHA的情况下，其与HDAC1 / 2/3和HDAC6的抑制作用有关。对-CHA的抗病毒活性比间-CHA的抗病毒活性强很多倍，而HDAC1 / 2/3/6的抑制效率几乎相同，
• Benzofurans and benzothiophenes having antiallergic activity and method
  申请人：Warner-Lambert Company

  公开号：US04910317A1

  公开（公告）日：1990-03-20

  Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome. The benzothiophenes of the present invention are particularly 2-tetrazolylcarboxamides of the benzothiophenes.

  具有抗过敏活性的新型苯并噻吩，以及用于治疗急性呼吸窘迫综合征的新型和其他选择的苯并噻吩。本发明的苯并噻吩特别是苯并噻吩的2-四唑基甲酰胺。
• TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE
  申请人：Boger Dale L.

  公开号：US20100249078A1

  公开（公告）日：2010-09-30

  Certain tetracyclic compounds are described, which may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).

  本文描述了某些四环化合物，可用于制备药物组合物和方法，用于治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态、障碍和病况。因此，这些化合物可以用于治疗焦虑、疼痛、炎症、睡眠障碍、进食障碍或运动障碍（例如多发性硬化）。