2-hydroxy-N-[2-(2-hydroxyacetylamino)cyclohexyl]acetamide | 1027585-24-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-hydroxy-N-[2-(2-hydroxyacetylamino)cyclohexyl]acetamide
• 英文别名: 2-hydroxy-N-[(1R,2R)-2-[(2-hydroxyacetyl)amino]cyclohexyl]acetamide
• CAS: 1027585-24-5
• 化学式: C₁₀H₁₈N₂O₄
• 分子量: 230.264
• InChiKey: BYRUAHPFORRCLS-HTQZYQBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-hydroxy-N-[2-(2-hydroxyacetylamino)cyclohexyl]acetamide 、 4,4'-双甲氧基三苯甲基氯 在 吡啶 作用下， 以50%的产率得到2-[bis-(4-methoxyphenyl)phenylmethoxy]-N-[2-(2-hydroxyacetylamino)cyclohexyl]acetamide
  参考文献：
  名称：

  Oligopyrenotides: Abiotic, Polyanionic Oligomers with Nucleic Acid-like Structural Properties

  摘要：

  Oligopyrenotides, abiotic oligomers that exhibit significant structural analogies to the nucleic acids, are described. They are composed of achiral, phosphodiester-linked pyrene building blocks and a single chiral 1,2-diaminocyclohexane unit. These oligomers form stable hybrids in aqueous solution. Hybridization is based on stacking interactions of the pyrene building blocks. They show thermal denaturation/renaturation behavior that closely resembles DNA and RNA hybridization. In addition, oligopyrenotides display salt-concentration-dependent structural polymorphism. Thus, they possess a number of structural attributes that are typical of nucleic acids and therefore may serve as model systems for the design of artificial self-replicating systems.

  DOI：

  10.1021/ja102042p
• 作为产物：
  描述：

  2-benzyloxy-N-[2-(2-benzyloxyacetylamino)cyclohexyl]acetamide 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以90%的产率得到2-hydroxy-N-[2-(2-hydroxyacetylamino)cyclohexyl]acetamide
  参考文献：
  名称：

  Oligopyrenotides: Abiotic, Polyanionic Oligomers with Nucleic Acid-like Structural Properties

  摘要：

  Oligopyrenotides, abiotic oligomers that exhibit significant structural analogies to the nucleic acids, are described. They are composed of achiral, phosphodiester-linked pyrene building blocks and a single chiral 1,2-diaminocyclohexane unit. These oligomers form stable hybrids in aqueous solution. Hybridization is based on stacking interactions of the pyrene building blocks. They show thermal denaturation/renaturation behavior that closely resembles DNA and RNA hybridization. In addition, oligopyrenotides display salt-concentration-dependent structural polymorphism. Thus, they possess a number of structural attributes that are typical of nucleic acids and therefore may serve as model systems for the design of artificial self-replicating systems.

  DOI：

  10.1021/ja102042p

文献信息

• Oligopyrenotides: Abiotic, Polyanionic Oligomers with Nucleic Acid-like Structural Properties
  作者：Robert Häner、Florian Garo、Daniel Wenger、Vladimir L. Malinovskii

  DOI：10.1021/ja102042p

  日期：2010.6.2

  Oligopyrenotides, abiotic oligomers that exhibit significant structural analogies to the nucleic acids, are described. They are composed of achiral, phosphodiester-linked pyrene building blocks and a single chiral 1,2-diaminocyclohexane unit. These oligomers form stable hybrids in aqueous solution. Hybridization is based on stacking interactions of the pyrene building blocks. They show thermal denaturation/renaturation behavior that closely resembles DNA and RNA hybridization. In addition, oligopyrenotides display salt-concentration-dependent structural polymorphism. Thus, they possess a number of structural attributes that are typical of nucleic acids and therefore may serve as model systems for the design of artificial self-replicating systems.