2,6-difluoro-N-(3H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonamido)benzamide | 1186223-05-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-difluoro-N-(3H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonamido)benzamide
• 英文别名: 2,6-Difluoro-N-(1h-Imidazo[4,5-B]pyridin-6-Yl)-3-[(Propylsulfonyl)amino]benzamide；2,6-difluoro-N-(1H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonylamino)benzamide
• CAS: 1186223-05-1
• 化学式: C₁₆H₁₅F₂N₅O₃S
• 分子量: 395.39
• InChiKey: CWDHWLRBSAIDBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  3,5-二硝基-2-氨基吡啶 在 palladium 10% on activated carbon ammonium sulfide 、 氢气 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 甲醇 、 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 2,6-difluoro-N-(3H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonamido)benzamide
  参考文献：
  名称：

  [EN] IMIDAZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS
  [FR] DÉRIVÉS D'IMIDAZO[4,5-B]PYRIDINE UTILISÉS COMME INHIBITEURS DE RAF

  摘要：

  公开号：

  WO2009111277A9

文献信息

• IMIDAZO [4,5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS
  申请人：Ahrendt Kateri A.

  公开号：US20110003809A1

  公开（公告）日：2011-01-06

  Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

  公式I的化合物对于抑制Raf激酶非常有用。本文公开了使用公式I的化合物、立体异构体和药学上可接受的盐，在哺乳动物细胞中进行体外、体内和原位诊断、预防或治疗这种疾病或相关病理状态的方法。
• Pyrazolopyridine Inhibitors of B-Raf^V600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors
  作者：Steve Wenglowsky、Li Ren、Kateri A. Ahrendt、Ellen R. Laird、Ignacio Aliagas、Bruno Alicke、Alex J. Buckmelter、Edna F. Choo、Victoria Dinkel、Bainian Feng、Susan L. Gloor、Stephen E. Gould、Stefan Gross、Janet Gunzner-Toste、Joshua D. Hansen、Georgia Hatzivassiliou、Bonnie Liu、Kim Malesky、Simon Mathieu、Brad Newhouse、Nicholas J. Raddatz、Yingqing Ran、Sumeet Rana、Nikole Randolph、Tyler Risom、Joachim Rudolph、Scott Savage、LeAnn T. Selby、Michael Shrag、Kyung Song、Hillary L. Sturgis、Walter C. Voegtli、Zhaoyang Wen、Brandon S. Willis、Richard D. Woessner、Wen-I Wu、Wendy B. Young、Jonas Grina

  DOI：10.1021/ml200025q

  日期：2011.5.12

  The V600E mutation of B-Raf kinase results in constitutive activation of the MAPK signaling pathway and is present in approximately 7% of all cancers. Using structure-based design, a novel series of pyrazolopyridine inhibitors of B-Raf(V600E) was developed. Optimization led to the identification of 3-methoxy pyrazolopyridines 17 and 19, potent, selective, and orally bioavailable agents that inhibited tumor growth in a mouse xenograft model driven by B-Raf(V600E) with no effect on body weight. On the basis of their in vivo efficacy and preliminary safety profiles, 17 and 19 were selected for further preclinical evaluation.
• IMDIZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS
  申请人：Array Biopharma, Inc.

  公开号：EP2265609B1

  公开（公告）日：2012-09-05
• [EN] IMDIZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS<br/>[FR] DÉRIVÉS D'IMIDAZO[4,5-B]PYRIDINE UTILISÉS COMME INHIBITEURS DE RAF
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2009111277A1

  公开（公告）日：2009-09-11

  Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
• [EN] IMIDAZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS<br/>[FR] DÉRIVÉS D'IMIDAZO[4,5-B]PYRIDINE UTILISÉS COMME INHIBITEURS DE RAF
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2009111277A9

  公开（公告）日：2009-12-30