(1R,2R)-1-phenylpropane-1,2-diamine | 198221-77-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1R,2R)-1-phenylpropane-1,2-diamine
• CAS: 198221-77-1
• 化学式: C₉H₁₄N₂
• 分子量: 150.224
• InChiKey: PRCXGQJVEKZKQR-APPZFPTMSA-N

物化性质

• 沸点：
  270.3±20.0 °C(Predicted)
• 密度：
  1.020±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1R,2R)-1-phenylpropane-1,2-diamine 在 sodium hydroxide 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 苯 为溶剂， 生成 (1S,2S)-1-phenyl-N¹,N²-dimethyl-1,2-propandiamine
  参考文献：
  名称：

  N,N′-Dialkylated 1,2-diamine derivatives as new efficient ligands for RuCl2(PPh3)3 catalyzed asymmetric transfer hydrogenation of aromatic ketones

  摘要：

  Chiral N,N'-dialkylated cyclohexanediamine derivatives ligands have been synthesized and used in an asymmetric transfer hydrogenation of aryl ketones. Optically active alcohols with up to 93% enantiomeric excess were obtained in high yield. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)01962-7
• 作为产物：
  描述：

  L-(-)-去甲伪麻黄碱 在 lithium aluminium tetrahydride 、 sodium azide 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 (1R,2R)-1-phenylpropane-1,2-diamine
  参考文献：
  名称：

  N,N′-Dialkylated 1,2-diamine derivatives as new efficient ligands for RuCl2(PPh3)3 catalyzed asymmetric transfer hydrogenation of aromatic ketones

  摘要：

  Chiral N,N'-dialkylated cyclohexanediamine derivatives ligands have been synthesized and used in an asymmetric transfer hydrogenation of aryl ketones. Optically active alcohols with up to 93% enantiomeric excess were obtained in high yield. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)01962-7

文献信息

• CATALYSTS AND PROCESSES FOR THE HYDROGENATION OF AMIDES
  申请人：Bergens Steven

  公开号：US20140163225A1

  公开（公告）日：2014-06-12

  There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides.

  提供了一种过程，用于在存在或不存在碱的条件下，将化合物与氢气和过渡金属催化剂接触，以还原一个或多个酰胺基团。目前描述的这些过程可以在低催化剂负载下进行，使用相对温和的温度和压力，并且可以选择在存在或不存在碱或高催化剂负载下使用低温和低压以及高负载碱的条件下，实现不对映体酰胺的动态动力学分辨。
• NOVEL RUTHENIUM CATALYSTS AND THEIR USE FOR ASYMMETRIC REDUCTION OF KETONES
  申请人：HADDAD Nizar

  公开号：US20150005500A1

  公开（公告）日：2015-01-01

  Disclosed are novel ruthenium compounds of formula (Ia) and (Ib): wherein R 1 and the moiety are defined herein. Also disclosed is a process for using these novel ruthenium compounds as catalysts for asymmetric hydrogenation and transfer hydrogenation of ketones with high reactivities and excellent selectivities.

  本发明揭示了一种新型钌化合物的化学式(Ia)和(Ib)：其中R1和该基团在此定义。还揭示了一种使用这些新型钌化合物作为催化剂进行酮类的不对称氢化和转移氢化的方法，具有高反应性和优异选择性。
• PROCESS FOR THE ASYMMETRIC HYDROGENATION OF IMIDES
  申请人：Bergens Steven H.

  公开号：US20120165546A1

  公开（公告）日：2012-06-28

  The present disclosure provides a process for the mono-reduction of one or more imide moieties in a compound comprising contacting the compound with hydrogen gas and a catalyst comprising a transition metal hydride in the presence of a base, under conditions for the mono-reduction of the one or more imide moieties to form a compound comprising one or more hydroxy amides.
• BENZAMIDES
  申请人：Merck Patent GmbH

  公开号：US20170022191A1

  公开（公告）日：2017-01-26

  Novel benzamide derivatives of formula (I) wherein W 1 , W 2 , R 1 to R 7 , R 6 , X and Y have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
• US9029540B2
  申请人：——

  公开号：US9029540B2

  公开（公告）日：2015-05-12