(1S,2S)-1-phenyl-N¹,N²-dimethyl-1,2-propandiamine | 130857-97-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1S,2S)-1-phenyl-N¹,N²-dimethyl-1,2-propandiamine
• 英文别名: threo-N,N'-dimethyl-1-phenylpropane-1,2-diamine；(1S,2S)-1-N,2-N-dimethyl-1-phenylpropane-1,2-diamine
• CAS: 130857-97-5
• 化学式: C₁₁H₁₈N₂
• 分子量: 178.277
• InChiKey: WLFWGHGVSWNVJT-GXSJLCMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-二苯基膦苯甲醛 、 (1S,2S)-1-phenyl-N¹,N²-dimethyl-1,2-propandiamine 以 1,4-二氧六环 为溶剂， 生成 diphenyl-[2-[(4S,5S)-1,3,4-trimethyl-5-phenylimidazolidin-2-yl]phenyl]phosphane
  参考文献：
  名称：

  N,N′-Dialkylated 1,2-diamine derivatives as new efficient ligands for RuCl2(PPh3)3 catalyzed asymmetric transfer hydrogenation of aromatic ketones

  摘要：

  Chiral N,N'-dialkylated cyclohexanediamine derivatives ligands have been synthesized and used in an asymmetric transfer hydrogenation of aryl ketones. Optically active alcohols with up to 93% enantiomeric excess were obtained in high yield. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)01962-7
• 作为产物：
  描述：

  (1R,2R)-1-phenylpropane-1,2-diamine 在 sodium hydroxide 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 苯 为溶剂， 生成 (1S,2S)-1-phenyl-N¹,N²-dimethyl-1,2-propandiamine
  参考文献：
  名称：

  N,N′-Dialkylated 1,2-diamine derivatives as new efficient ligands for RuCl2(PPh3)3 catalyzed asymmetric transfer hydrogenation of aromatic ketones

  摘要：

  Chiral N,N'-dialkylated cyclohexanediamine derivatives ligands have been synthesized and used in an asymmetric transfer hydrogenation of aryl ketones. Optically active alcohols with up to 93% enantiomeric excess were obtained in high yield. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)01962-7

文献信息

• Tytgat, D.; Gelbcke, M., Bulletin des Societes Chimiques Belges, 1990, vol. 99, # 5, p. 329 - 334
  作者：Tytgat, D.、Gelbcke, M.

  DOI：——

  日期：——
• Gelbcke, M.; Tytgat, D., Bulletin des Societes Chimiques Belges, 1993, vol. 102, # 1, p. 67 - 74
  作者：Gelbcke, M.、Tytgat, D.

  DOI：——

  日期：——
• Tytgat; Gelbcke; Smith, Pharmazie, 1990, vol. 45, # 11, p. 835 - 836
  作者：Tytgat、Gelbcke、Smith

  DOI：——

  日期：——
• N,N′-Dialkylated 1,2-diamine derivatives as new efficient ligands for RuCl2(PPh3)3 catalyzed asymmetric transfer hydrogenation of aromatic ketones
  作者：Geon-Joong Kim、Sang-Han Kim、Pong-Hyun Chong、Mi-Ae Kwon

  DOI：10.1016/s0040-4039(02)01962-7

  日期：2002.11

  Chiral N,N'-dialkylated cyclohexanediamine derivatives ligands have been synthesized and used in an asymmetric transfer hydrogenation of aryl ketones. Optically active alcohols with up to 93% enantiomeric excess were obtained in high yield. (C) 2002 Published by Elsevier Science Ltd.