7-Chloro-1,3-dihydro-5-(4-methoxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one | 216691-88-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 7-Chloro-1,3-dihydro-5-(4-methoxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
• 英文别名: 7-chloro-5-(4-methoxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-3H-1,4-benzodiazepin-2-one
• CAS: 216691-88-2
• 化学式: C₂₈H₂₃ClN₂O₂
• 分子量: 454.9
• InChiKey: KXKSBRQOXBPTTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Methods and compositions for treating diseases and conditions associated with mitochondrial function
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：EP2216073A1

  公开（公告）日：2010-08-11

  The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, mitochondrial F1F0 ATP hydrolase associated disorders, and the like.

  本发明涉及化合物、发现化合物的方法及其治疗用途。特别是，本发明提供了作为治疗剂的化合物，用于治疗与程序性细胞死亡、自身免疫、炎症、过度增殖、线粒体 F1F0 ATP水解酶相关紊乱等过程的调节失误有关的多种疾病。
• Compositions and methods relating to novel compounds and targets thereof
  申请人：Glick D. Gary

  公开号：US20070135418A1

  公开（公告）日：2007-06-14

  The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.
• Compostions and methods relating to novel compounds and targets thereof
  申请人：Glick D. Gary

  公开号：US20070299059A1

  公开（公告）日：2007-12-27

  The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.
• COMPOSITIONS AND METHODS RELATING TO NOVEL COMPOUNDS AND TARGETS THEREOF
  申请人：Glick Gary D.

  公开号：US20080269203A1

  公开（公告）日：2008-10-30

  The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.
• BENZODIAZEPINE COMPOSITIONS FOR TREATING EPIDERMAL HYPERPLASIA AND RELATED DISORDERS
  申请人：Glick Gary D.

  公开号：US20100222310A1

  公开（公告）日：2010-09-02

  The present invention provides, for example, pharmaceutical compositions comprising a benzodiazepine compound and an agent selected from the group consisting of a topical steroid, a keratolytic agent, a topical retinoid, a coal tar, and a vitamin D-3 analog. The pharmaceutical compositions are useful for treating medical disorders, such as epidermal hyperplasia