Heptanoic acid, 5,6,7-trihydroxy- | 869334-13-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: Heptanoic acid, 5,6,7-trihydroxy-
• 英文别名: 5,6,7-trihydroxyheptanoic acid
• CAS: 869334-13-4
• 化学式: C₇H₁₄O₅
• 分子量: 178.18
• InChiKey: AKGMFVVQMGQGBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Method of reducing intraocular pressure and treating glaucoma
  申请人：Klimko G. Peter

  公开号：US20060154981A1

  公开（公告）日：2006-07-13

  The use of 5,6,7-trihydroxyheptanoic acid and analogs for the treatment of ocular hypertension and glaucoma is disclosed.

  本发明揭示了使用5,6,7-三羟基庚酸及其类似物治疗眼压增高和青光眼的方法。
• Method of Treating Asthma, Allergic Rhinitis, and Skin Disorders
  申请人：Klimko G. Peter

  公开号：US20080108695A1

  公开（公告）日：2008-05-08

  The use of 5,6,7-trihydroxyheptanoic acid and analogs is disclosed for the treatment of asthma, allergic rhinitis, and skin disorders such as allergic dermatitis, contact hypersensitivity, urticaria (hives), rosacea, or psoriasis.

  使用5,6,7-三羟基庚酸及其类似物来治疗哮喘、过敏性鼻炎以及皮肤疾病，如过敏性皮炎、接触性过敏、荨麻疹（风疹）、酒渣鼻或牛皮癣。
• 5,6,7-Trihydroxyheptanoic acid and analogs for the treatment of ocular diseases and diseases associated with hyperproliferative and angiogenic responses
  申请人：Klimko G. Peter

  公开号：US20060099248A1

  公开（公告）日：2006-05-11

  Compositions containing 5,6,7-trihydroxyheptanoic acid and analogs and their use for treating posterior segment ocular diseases and diseases characterized by cellular hyperproliferation or angiogenesis, are disclosed.

  本发明涉及含有5,6,7-三羟基庚酸及其类似物的组合物，以及它们用于治疗后部眼部疾病和细胞增殖或血管生成特征的疾病的用途。
• Dually derivatized chitosan nanoparticles and methods of making and using the same for gene transfer in vivo
  申请人：ENGENE, INC.

  公开号：US10456481B2

  公开（公告）日：2019-10-29

  Provided herein is chitosan-derivative nanoparticle comprising chitosan functionalized with a cationic amino acid and a hydrophilic polyol; and methods of making and using same, e.g., for gene delivery in vivo.

  本文提供了壳聚糖衍生物纳米粒子，包括用阳离子氨基酸和亲水多元醇官能化的壳聚糖；以及制造和使用这种纳米粒子的方法，例如用于体内基因递送。
• Method of treating dry eye disorders and uveitis
  申请人：Klimko G. Peter

  公开号：US20050256189A1

  公开（公告）日：2005-11-17

  The topical use of 5,6,7-trihydroxyheptanoic acid and analogs are disclosed for the treatment of dry eye disorders and uveitis.

  公开了 5,6,7-三羟基庚酸及其类似物的局部使用方法，用于治疗干眼症和葡萄膜炎。