BVD-523 | 869886-68-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: BVD-523
• 英文别名: 4-[5-Chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-2-hydroxy-1-phenylethyl]-1H-pyrrole-2-carboxamide；4-[5-chloro-2-(propan-2-ylamino)pyridin-4-yl]-N-[(1S)-2-hydroxy-1-phenylethyl]-1H-pyrrole-2-carboxamide
• CAS: 869886-68-0
• 化学式: C₂₁H₂₃ClN₄O₂
• 分子量: 398.892
• InChiKey: JMRBTHGMBQQAQI-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  90
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Pyrrole compounds as inhibitors of ERK protein kinases and pharmaceutical compositions containing these compounds
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP2799434A1

  公开（公告）日：2014-11-05

  The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

  本发明涉及可作为蛋白激酶抑制剂的化合物。本发明还提供了包含所述化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病、病症或失调的方法。
• PYRROLE COMPOUNDS AS INHIBITORS OF ERK PROTEIN KINASES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP3305776A1

  公开（公告）日：2018-04-11

  The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

  本发明涉及可作为蛋白激酶抑制剂的化合物。本发明还提供了包含所述化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病、病症或失调的方法。
• PYRROLE INHIBITORS OF ERK PROTEIN KINASE, SYNTHESIS THEREOF AND INTERMEDIATES THERETO
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP3943489A1

  公开（公告）日：2022-01-26

  The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

  本发明涉及可作为蛋白激酶抑制剂的化合物。本发明还提供了包含所述化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病、病症或失调的方法。
• US7354939B2
  申请人：——

  公开号：US7354939B2

  公开（公告）日：2008-04-08
• USRE46097E1
  申请人：——

  公开号：USRE46097E1

  公开（公告）日：2016-08-09