FCIGRL | 835872-35-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: FCIGRL
• 英文别名: AT-1002；L-Leucine, L-phenylalanyl-L-cysteinyl-L-isoleucylglycyl-L-arginyl-；(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoic acid
• CAS: 835872-35-0
• 化学式: C₃₂H₅₃N₉O₇S
• 分子量: 707.895
• InChiKey: LADIUXCZKYKVRR-PSEZLDIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  49
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  274
• 氢给体数：
  10
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  FCIGRL 在 双氧水 作用下， 以 水 、 乙腈 为溶剂， 反应 2.0h， 以100%的产率得到H-Phe-Cys(1)-Ile-Gly-Arg-Leu-OH.H-Phe-Cys(1)-Ile-Gly-Arg-Leu-OH
  参考文献：
  名称：

  Structure–activity relationship studies of permeability modulating peptide AT-1002

  摘要：

  AT-1002 a 6-mer synthetic peptide belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. The aim of this project was to elaborate on the structure-activity relationship of this peptide with the specific goal to replace the P2 cysteine amino acid. Herein, we report the discovery of peptides that exhibit reversible permeability enhancement properties with an increased stability profile. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.028
• 作为产物：
  描述：

  在 三乙基硅烷 、 三氟乙酸 作用下， 以 水 为溶剂， 反应 2.0h， 生成 FCIGRL
  参考文献：
  名称：

  Structure–activity relationship studies of permeability modulating peptide AT-1002

  摘要：

  AT-1002 a 6-mer synthetic peptide belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. The aim of this project was to elaborate on the structure-activity relationship of this peptide with the specific goal to replace the P2 cysteine amino acid. Herein, we report the discovery of peptides that exhibit reversible permeability enhancement properties with an increased stability profile. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.028

文献信息

• Structure–activity relationship studies of permeability modulating peptide AT-1002
  作者：Min Li、Ed Oliver、Kelly M. Kitchens、John Vere、Sefik S. Alkan、Amir P. Tamiz

  DOI：10.1016/j.bmcl.2008.07.028

  日期：2008.8

  AT-1002 a 6-mer synthetic peptide belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. The aim of this project was to elaborate on the structure-activity relationship of this peptide with the specific goal to replace the P2 cysteine amino acid. Herein, we report the discovery of peptides that exhibit reversible permeability enhancement properties with an increased stability profile. (C) 2008 Elsevier Ltd. All rights reserved.