1-(1H-Indol-3-yl)-2-(1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-1,2-ethanedione | 870471-41-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(1H-Indol-3-yl)-2-(1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-1,2-ethanedione
• 英文别名: 1-(1H-indol-3-yl)-2-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)ethane-1,2-dione
• CAS: 870471-41-3
• 化学式: C₂₁H₁₇N₃O₂
• 分子量: 343.4
• InChiKey: ALNLRFQRCIMEGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  69
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Tetrahydrocarboline antiviral agents
  申请人：Ruediger H. Edward

  公开号：US20050267130A1

  公开（公告）日：2005-12-01

  The invention encompasses a series of tetrahydrocarboline compounds of Formula I which inhibit HIV entry by attaching to the exterior viral envelop protein gp120 and interrupting the viral entry process, possibly by interfering with the cellular receptor CD4. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

  该发明涵盖了一系列的四氢喹啉化合物，其化学式为I，通过与病毒外包膜蛋白gp120结合并干扰病毒进入过程来抑制HIV进入，可能是通过干扰细胞受体CD4来实现的。这种作用使得这些化合物在治疗HIV感染和艾滋病方面非常有用。该发明还涵盖了用于治疗HIV感染者的药物组合物和方法。
• US7449476B2
  申请人：——

  公开号：US7449476B2

  公开（公告）日：2008-11-11
• [EN] TETRAHYDROCARBOLINE ANTIVIRAL AGENTS<br/>[FR] AGENTS ANTIVIRAUX TETRAHYDROCARBOLINE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2005117868A1

  公开（公告）日：2005-12-15

  The invention encompasses a series of tetrahydrocarboline compounds of Formula I (I) which inhibit HIV entry by attaching to the exterior viral envelop protein gp120 and interrupting the viral entry process, possibly by interfering with the cellular receptor CD4. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.