(2R)-3-[3,4-bis(phenylmethoxy)phenoxy]propane-1,2-diol | 909415-01-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2R)-3-[3,4-bis(phenylmethoxy)phenoxy]propane-1,2-diol
• CAS: 909415-01-6
• 化学式: C₂₃H₂₄O₅
• 分子量: 380.441
• InChiKey: MNHBGONSOAYMIH-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2R)-3-[3,4-bis(phenylmethoxy)phenoxy]propane-1,2-diol 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 苯 为溶剂， 反应 15.0h， 以85%的产率得到(R)-2-{[3,4-bis(benzyloxy)phenoxy]methyl}oxirane
  参考文献：
  名称：

  Asymmetric Synthesis of (2S)‐1‐(3,4‐Dihydroxyphenoxy)‐3‐(3,′4′‐Dimethoxyphenoxy) Ethylamino‐2‐propanol hydrochloride (RO363)

  摘要：

  Enantiomerically pure (S)-RO363 was synthesized by using (R,R) Salen Co(III) complex for the resolution of terminal epoxide. The hydrolytic kinetic resolution process was carried out at room temperature in excellent enantioselectivity. The method can be applied for large-scale preparation of (S)RO363.

  DOI：

  10.1080/00397910600602651
• 作为产物：
  描述：

  3,4-二苄氧基苯酚 在 (S,S)-(salen)cobalt(III)(OAc) 氢氧化钾 作用下， 以 乙醇 、 水 为溶剂， 反应 35.0h， 生成 (2R)-3-[3,4-bis(phenylmethoxy)phenoxy]propane-1,2-diol
  参考文献：
  名称：

  Asymmetric Synthesis of (2S)‐1‐(3,4‐Dihydroxyphenoxy)‐3‐(3,′4′‐Dimethoxyphenoxy) Ethylamino‐2‐propanol hydrochloride (RO363)

  摘要：

  Enantiomerically pure (S)-RO363 was synthesized by using (R,R) Salen Co(III) complex for the resolution of terminal epoxide. The hydrolytic kinetic resolution process was carried out at room temperature in excellent enantioselectivity. The method can be applied for large-scale preparation of (S)RO363.

  DOI：

  10.1080/00397910600602651

文献信息

• Asymmetric Synthesis of (2S)‐1‐(3,4‐Dihydroxyphenoxy)‐3‐(3,′4′‐Dimethoxyphenoxy) Ethylamino‐2‐propanol hydrochloride (RO363)
  作者：Akkirala Venkat Narsaiah

  DOI：10.1080/00397910600602651

  日期：2006.7

  Enantiomerically pure (S)-RO363 was synthesized by using (R,R) Salen Co(III) complex for the resolution of terminal epoxide. The hydrolytic kinetic resolution process was carried out at room temperature in excellent enantioselectivity. The method can be applied for large-scale preparation of (S)RO363.